Explicit tracking of uncertainty increases the power of quantitative rule-of-thumb reasoning in cell biology

"Back-of-the-envelope" or "rule-of-thumb" calculations involving rough estimates of quantities play a central scientific role in developing intuition about the structure and behaviour of physical systems, for example in so-called `Fermi problems' in the physical sciences. Such calculations can be used to powerfully and quantitatively reason about biological systems, particularly at the interface between physics and biology. However, substantial uncertainties are often associated with values in cell biology, and performing calculations without taking this uncertainty into account may limit the extent to which results can be interpreted for a given problem. We present a means to facilitate such calculations where uncertainties are explicitly tracked through the line of reasoning, and introduce a `probabilistic calculator' called Caladis, a web tool freely available at www.caladis.org, designed to perform this tracking. This approach allows users to perform more statistically robust calculations in cell biology despite having uncertain values, and to identify which quantities need to be measured more precisely in order to make confident statements, facilitating efficient experimental design. We illustrate the use of our tool for tracking uncertainty in several example biological calculations, showing that the results yield powerful and interpretable statistics on the quantities of interest. We also demonstrate that the outcomes of calculations may differ from point estimates when uncertainty is accurately tracked. An integral link between Caladis and the Bionumbers repository of biological quantities further facilitates the straightforward location, selection, and use of a wealth of experimental data in cell biological calculations.Comment: 8 pages, 3 figure

Spatial Wireless Channel Prediction under Location Uncertainty

Spatial wireless channel prediction is important for future wireless networks, and in particular for proactive resource allocation at different layers of the protocol stack. Various sources of uncertainty must be accounted for during modeling and to provide robust predictions. We investigate two channel prediction frameworks, classical Gaussian processes (cGP) and uncertain Gaussian processes (uGP), and analyze the impact of location uncertainty during learning/training and prediction/testing, for scenarios where measurements uncertainty are dominated by large-scale fading. We observe that cGP generally fails both in terms of learning the channel parameters and in predicting the channel in the presence of location uncertainties.\textcolor{blue}{{} }In contrast, uGP explicitly considers the location uncertainty. Using simulated data, we show that uGP is able to learn and predict the wireless channel

Applications of Soft Computing in Mobile and Wireless Communications

Soft computing is a synergistic combination of artificial intelligence methodologies to model and solve real world problems that are either impossible or too difficult to model mathematically. Furthermore, the use of conventional modeling techniques demands rigor, precision and certainty, which carry computational cost. On the other hand, soft computing utilizes computation, reasoning and inference to reduce computational cost by exploiting tolerance for imprecision, uncertainty, partial truth and approximation. In addition to computational cost savings, soft computing is an excellent platform for autonomic computing, owing to its roots in artificial intelligence. Wireless communication networks are associated with much uncertainty and imprecision due to a number of stochastic processes such as escalating number of access points, constantly changing propagation channels, sudden variations in network load and random mobility of users. This reality has fuelled numerous applications of soft computing techniques in mobile and wireless communications. This paper reviews various applications of the core soft computing methodologies in mobile and wireless communications

Quality of Information in Mobile Crowdsensing: Survey and Research Challenges

Smartphones have become the most pervasive devices in people's lives, and are clearly transforming the way we live and perceive technology. Today's smartphones benefit from almost ubiquitous Internet connectivity and come equipped with a plethora of inexpensive yet powerful embedded sensors, such as accelerometer, gyroscope, microphone, and camera. This unique combination has enabled revolutionary applications based on the mobile crowdsensing paradigm, such as real-time road traffic monitoring, air and noise pollution, crime control, and wildlife monitoring, just to name a few. Differently from prior sensing paradigms, humans are now the primary actors of the sensing process, since they become fundamental in retrieving reliable and up-to-date information about the event being monitored. As humans may behave unreliably or maliciously, assessing and guaranteeing Quality of Information (QoI) becomes more important than ever. In this paper, we provide a new framework for defining and enforcing the QoI in mobile crowdsensing, and analyze in depth the current state-of-the-art on the topic. We also outline novel research challenges, along with possible directions of future work.Comment: To appear in ACM Transactions on Sensor Networks (TOSN

It’s a long way to Monte-Carlo: probabilistic display in GPS navigation

We present a mobile, GPS-based multimodal navigation system, equipped with inertial control that allows users to explore and navigate through an augmented physical space, incorporating and displaying the uncertainty resulting from inaccurate sensing and unknown user intentions. The system propagates uncertainty appropriately via Monte Carlo sampling and predicts at a user-controllable time horizon. Control of the Monte Carlo exploration is entirely tilt-based. The system output is displayed both visually and in audio. Audio is rendered via granular synthesis to accurately display the probability of the user reaching targets in the space. We also demonstrate the use of uncertain prediction in a trajectory following task, where a section of music is modulated according to the changing predictions of user position with respect to the target trajectory. We show that appropriate display of the full distribution of potential future users positions with respect to sites-of-interest can improve the quality of interaction over a simplistic interpretation of the sensed data

Fuzzy-logic-based control, filtering, and fault detection for networked systems: A Survey

This paper is concerned with the overview of the recent progress in fuzzy-logic-based filtering, control, and fault detection problems. First, the network technologies are introduced, the networked control systems are categorized from the aspects of fieldbuses and industrial Ethernets, the necessity of utilizing the fuzzy logic is justified, and the network-induced phenomena are discussed. Then, the fuzzy logic control strategies are reviewed in great detail. Special attention is given to the thorough examination on the latest results for fuzzy PID control, fuzzy adaptive control, and fuzzy tracking control problems. Furthermore, recent advances on the fuzzy-logic-based filtering and fault detection problems are reviewed. Finally, conclusions are given and some possible future research directions are pointed out, for example, topics on two-dimensional networked systems, wireless networked control systems, Quality-of-Service (QoS) of networked systems, and fuzzy access control in open networked systems.This work was supported in part by the National Natural Science Foundation of China under Grants 61329301, 61374039, 61473163, and 61374127, the Hujiang Foundation of China under Grants C14002 andD15009, the Engineering and Physical Sciences Research Council (EPSRC) of the UK, the Royal Society of the UK, and the Alexander von Humboldt Foundation of Germany

Scalable Approach to Uncertainty Quantification and Robust Design of Interconnected Dynamical Systems

Development of robust dynamical systems and networks such as autonomous aircraft systems capable of accomplishing complex missions faces challenges due to the dynamically evolving uncertainties coming from model uncertainties, necessity to operate in a hostile cluttered urban environment, and the distributed and dynamic nature of the communication and computation resources. Model-based robust design is difficult because of the complexity of the hybrid dynamic models including continuous vehicle dynamics, the discrete models of computations and communications, and the size of the problem. We will overview recent advances in methodology and tools to model, analyze, and design robust autonomous aerospace systems operating in uncertain environment, with stress on efficient uncertainty quantification and robust design using the case studies of the mission including model-based target tracking and search, and trajectory planning in uncertain urban environment. To show that the methodology is generally applicable to uncertain dynamical systems, we will also show examples of application of the new methods to efficient uncertainty quantification of energy usage in buildings, and stability assessment of interconnected power networks