Picturing the Invisible: Exploring interdisciplinary synergies from the arts and the sciences

Picturing the Invisible presents different disciplinary approaches to articulating the invisible, that which is not known or that which is not provable. The challenge that we have seen is how to articulate these concepts, not only to those within a particular academic field but beyond, to other disciplines and society at large. As our understanding of the complexity of the world grows incrementally, so does our realisation that issues and problems can rarely be resolved within neat demarcations. Therefore, the importance of finding means of communicating across disciplines and fields becomes a priority. Whilst acknowledging the essential importance of the specialist academic, the capacity to understand other disciplines, their priorities, methodologies and even the language used can become crucial in being an effective instrument for change. This book brings together insights from leading academics from a wide range of disciplines including Art and Design, Curatorial Practice, Literature, Forensic Science, Medical Science, Psychoanalysis and Psychotherapy, Philosophy, Astrophysics and Architecture with a shared interest in exploring how, in each discipline, we strive to find expression for the invisible or unknown, and to draw out and articulate some of the explicit and tacit ways of communicating those concepts that transcend traditional disciplinary boundaries

Picturing the Invisible

Picturing the Invisible presents different disciplinary approaches to articulating the invisible, that which is not known or that which is not provable. The challenge that we have seen is how to articulate these concepts, not only to those within a particular academic field but beyond, to other disciplines and society at large. As our understanding of the complexity of the world grows incrementally, so does our realisation that issues and problems can rarely be resolved within neat demarcations. Therefore, the importance of finding means of communicating across disciplines and fields becomes a priority. Whilst acknowledging the essential importance of the specialist academic, the capacity to understand other disciplines, their priorities, methodologies and even the language used can become crucial in being an effective instrument for change. This book brings together insights from leading academics from a wide range of disciplines including Art and Design, Curatorial Practice, Literature, Forensic Science, Fashion, Medical Science, Psychoanalysis and Psychotherapy, Philosophy, Astrophysics and Architecture with a shared interest in exploring how, in each discipline, we strive to find expression for the invisible or unknown, and to draw out and articulate some of the explicit and tacit ways of communicating those concepts that transcends traditional disciplinary boundaries

Picturing the Invisible

Picturing the Invisible presents different disciplinary approaches to articulating the invisible, that which is not known or that which is not provable. The challenge that we have seen is how to articulate these concepts, not only to those within a particular academic field but beyond, to other disciplines and society at large. As our understanding of the complexity of the world grows incrementally, so does our realisation that issues and problems can rarely be resolved within neat demarcations. Therefore, the importance of finding means of communicating across disciplines and fields becomes a priority. Whilst acknowledging the essential importance of the specialist academic, the capacity to understand other disciplines, their priorities, methodologies and even the language used can become crucial in being an effective instrument for change. This book brings together insights from leading academics from a wide range of disciplines including Art and Design, Curatorial Practice, Literature, Forensic Science, Fashion, Medical Science, Psychoanalysis and Psychotherapy, Philosophy, Astrophysics and Architecture with a shared interest in exploring how, in each discipline, we strive to find expression for the invisible or unknown, and to draw out and articulate some of the explicit and tacit ways of communicating those concepts that transcends traditional disciplinary boundaries

Psr1p interacts with SUN/sad1p and EB1/mal3p to establish the bipolar spindle

Regular Abstracts - Sunday Poster Presentations: no. 382During mitosis, interpolar microtubules from two spindle pole bodies (SPBs) interdigitate to create an antiparallel microtubule array for accommodating numerous regulatory proteins. Among these proteins, the kinesin-5 cut7p/Eg5 is the key player responsible for sliding apart antiparallel microtubules and thus helps in establishing the bipolar spindle. At the onset of mitosis, two SPBs are adjacent to one another with most microtubules running nearly parallel toward the nuclear envelope, creating an unfavorable microtubule configuration for the kinesin-5 kinesins. Therefore, how the cell organizes the antiparallel microtubule array in the first place at mitotic onset remains enigmatic. Here, we show that a novel protein psrp1p localizes to the SPB and plays a key role in organizing the antiparallel microtubule array. The absence of psr1+ leads to a transient monopolar spindle and massive chromosome loss. Further functional characterization demonstrates that psr1p is recruited to the SPB through interaction with the conserved SUN protein sad1p and that psr1p physically interacts with the conserved microtubule plus tip protein mal3p/EB1. These results suggest a model that psr1p serves as a linking protein between sad1p/SUN and mal3p/EB1 to allow microtubule plus ends to be coupled to the SPBs for organization of an antiparallel microtubule array. Thus, we conclude that psr1p is involved in organizing the antiparallel microtubule array in the first place at mitosis onset by interaction with SUN/sad1p and EB1/mal3p, thereby establishing the bipolar spindle.postprin

Removal of antagonistic spindle forces can rescue metaphase spindle length and reduce chromosome segregation defects

Regular Abstracts - Tuesday Poster Presentations: no. 1925Metaphase describes a phase of mitosis where chromosomes are attached and oriented on the bipolar spindle for subsequent segregation at anaphase. In diverse cell types, the metaphase spindle is maintained at a relatively constant length. Metaphase spindle length is proposed to be regulated by a balance of pushing and pulling forces generated by distinct sets of spindle microtubules and their interactions with motors and microtubule-associated proteins (MAPs). Spindle length appears important for chromosome segregation fidelity, as cells with shorter or longer than normal metaphase spindles, generated through deletion or inhibition of individual mitotic motors or MAPs, showed chromosome segregation defects. To test the force balance model of spindle length control and its effect on chromosome segregation, we applied fast microfluidic temperature-control with live-cell imaging to monitor the effect of switching off different combinations of antagonistic forces in the fission yeast metaphase spindle. We show that spindle midzone proteins kinesin-5 cut7p and microtubule bundler ase1p contribute to outward pushing forces, and spindle kinetochore proteins kinesin-8 klp5/6p and dam1p contribute to inward pulling forces. Removing these proteins individually led to aberrant metaphase spindle length and chromosome segregation defects. Removing these proteins in antagonistic combination rescued the defective spindle length and, in some combinations, also partially rescued chromosome segregation defects. Our results stress the importance of proper chromosome-to-microtubule attachment over spindle length regulation for proper chromosome segregation.postprin

It Was Handed to Them : The Origins of Targeted Delivery and the Spirit of Nanomedicine

Nanotechnology is widely recognized as an important field. Since the 2000s, nano-based targeting has been a cutting-edge approach in cancer research. To specify what nanomedicine means and describe its significance at the cultural level, this study harnesses data from peer-reviewed articles published in leading scientific journals. Balancing precariously between sociological theory and science and technology studies, this project turns to nanomedicine’s origins to address broader questions regarding the relationship between science and society and the causes of scientific discovery and technological innovation. It tells the story of nanotechnology\u27s discursive formations taking on a life of their own and congealing into a zeitgeist or spirit, as is reminiscent of the one described by Max Weber in The Protestant Ethic. It concludes that nanotechnology-based targeted delivery was not merely a scientific idea or a technical solution to the problem of cancer, but a broad cultural logic based on the waning of thinking in terms of warfare and blunt force, and the rise of an ethos centered around designing, creating and managing relationships, affinity, and engineering compatibility between things normally understood as incompatible

Life Sciences Program Tasks and Bibliography for FY 1997

This document includes information on all peer reviewed projects funded by the Office of Life and Microgravity Sciences and Applications, Life Sciences Division during fiscal year 1997. This document will be published annually and made available to scientists in the space life sciences field both as a hard copy and as an interactive internet web page