30,681 research outputs found
Tracing evolutionary links between species
The idea that all life on earth traces back to a common beginning dates back
at least to Charles Darwin's {\em Origin of Species}. Ever since, biologists
have tried to piece together parts of this `tree of life' based on what we can
observe today: fossils, and the evolutionary signal that is present in the
genomes and phenotypes of different organisms. Mathematics has played a key
role in helping transform genetic data into phylogenetic (evolutionary) trees
and networks. Here, I will explain some of the central concepts and basic
results in phylogenetics, which benefit from several branches of mathematics,
including combinatorics, probability and algebra.Comment: 18 pages, 6 figures (Invited review paper (draft version) for AMM
Modelling Food Webs
We review theoretical approaches to the understanding of food webs. After an
overview of the available food web data, we discuss three different classes of
models. The first class comprise static models, which assign links between
species according to some simple rule. The second class are dynamical models,
which include the population dynamics of several interacting species. We focus
on the question of the stability of such webs. The third class are species
assembly models and evolutionary models, which build webs starting from a few
species by adding new species through a process of "invasion" (assembly models)
or "speciation" (evolutionary models). Evolutionary models are found to be
capable of building large stable webs.Comment: 34 pages, 2 figures. To be published in "Handbook of graphs and
networks" S. Bornholdt and H. G. Schuster (eds) (Wiley-VCH, Berlin
Epidemic space
The aim of this article is to highlight the importance of 'spatiality' in understanding the materialization of risk society and cultivation of risk sensibilities. More specifically it provides a cultural analysis of pathogen virulence (as a social phenomenon) by means of tracing and mapping the spatial flows that operate in the uncharted zones between the microphysics of infection and the macrophysics of epidemics. It will be argued that epidemic space consists of three types of forces: the vector, the index and the vortex. It will draw on Latour's Actor Network Theory to argue that epidemic space is geared towards instability when the vortex (of expanding associations and concerns) displaces the index (of finding a single cause)
Integrating the landscape epidemiology and genetics of RNA viruses: rabies in domestic dogs as a model
Landscape epidemiology and landscape genetics combine advances in molecular techniques, spatial analyses and epidemiological models to generate a more real-world understanding of infectious disease dynamics and provide powerful new tools for the study of RNA viruses. Using dog rabies as a model we have identified how key questions regarding viral spread and persistence can be addressed using a combination of these techniques. In contrast to wildlife rabies, investigations into the landscape epidemiology of domestic dog rabies requires more detailed assessment of the role of humans in disease spread, including the incorporation of anthropogenic landscape features, human movements and socio-cultural factors into spatial models. In particular, identifying and quantifying the influence of anthropogenic features on pathogen spread and measuring the permeability of dispersal barriers are important considerations for planning control strategies, and may differ according to cultural, social and geographical variation across countries or continents. Challenges for dog rabies research include the development of metapopulation models and transmission networks using genetic information to uncover potential source/sink dynamics and identify the main routes of viral dissemination. Information generated from a landscape genetics approach will facilitate spatially strategic control programmes that accommodate for heterogeneities in the landscape and therefore utilise resources in the most cost-effective way. This can include the efficient placement of vaccine barriers, surveillance points and adaptive management for large-scale control programmes
Distinct genealogies for plasmids and chromosome
An earlier perspective on the diversity of conjugative elements in microbes [1] attempted to provide a broad audience with an introductory overview of the arcane biology of mobile genetic elements and their terminologies. It might well have been entitled "Plasmids, ICEs, IMEs, and Other Mobile Elements for Dummies," but common sense prevailed. This perspective introduces two related articles in the current issue of PLOS Genetics [2,3] and might have equally aptly been entitled "Antibiotic-Resistant Plasmids and Their Epidemiology for Dummies.
A Bayesian approach for inferring the dynamics of partially observed endemic infectious diseases from space-time-genetic data
We describe a statistical framework for reconstructing the sequence of transmission events between observed cases of an endemic infectious disease using genetic, temporal and spatial information. Previous approaches to reconstructing transmission trees have assumed all infections in the study area originated from a single introduction and that a large fraction of cases were observed. There are as yet no approaches appropriate for endemic situations in which a disease is already well established in a host population and in which there may be multiple origins of infection, or that can enumerate unobserved infections missing from the sample. Our proposed framework addresses these shortcomings, enabling reconstruction of partially observed transmission trees and estimating the number of cases missing from the sample. Analyses of simulated datasets show the method to be accurate in identifying direct transmissions, while introductions and transmissions via one or more unsampled intermediate cases could be identified at high to moderate levels of case detection. When applied to partial genome sequences of rabies virus sampled from an endemic region of South Africa, our method reveals several distinct transmission cycles with little contact between them, and direct transmission over long distances suggesting significant anthropogenic influence in the movement of infected dogs
Evolutionary biology for the 21st century
New theoretical and conceptual frameworks are required for evolutionary biology to capitalize on the wealth of data now becoming available from the study of genomes, phenotypes, and organisms - including humans - in their natural environments.Molecular and Cellular BiologyOrganismic and Evolutionary Biolog
- …