Minding the Gap: Computing Ethics and the Political Economy of Big Tech

In 1988 Michael Mahoney wrote that “[w]hat is truly revolutionary about the computer will become clear only when computing acquires a proper history, one that ties it to other technologies and thus uncovers the precedents that make its innovations significant” (Mahoney, 1988). Today, over thirty years after this quote was written, we are living right in the middle of the information age and computing technology is constantly transforming modern living in revolutionary ways and in such a high degree that is giving rise to many ethical considerations, dilemmas, and social disruption. To explore the myriad of issues associated with the ethical challenges of computers using the lens of political economy it is important to explore the history and development of computer technology

Timely and reliable evaluation of the effects of interventions: a framework for adaptive meta-analysis (FAME)

Most systematic reviews are retrospective and use aggregate data AD) from publications, meaning they can be unreliable, lag behind therapeutic developments and fail to influence ongoing or new trials. Commonly, the potential influence of unpublished or ongoing trials is overlooked when interpreting results, or determining the value of updating the meta-analysis or need to collect individual participant data (IPD). Therefore, we developed a Framework for Adaptive Metaanalysis (FAME) to determine prospectively the earliest opportunity for reliable AD meta-analysis. We illustrate FAME using two systematic reviews in men with metastatic (M1) and non-metastatic (M0)hormone-sensitive prostate cancer (HSPC)