9,611 research outputs found
A Framework for XML-based Integration of Data, Visualization and Analysis in a Biomedical Domain
Biomedical data are becoming increasingly complex and heterogeneous in nature. The data are stored in distributed information systems, using a variety of data models, and are processed by increasingly more complex tools that analyze and visualize them. We present in this paper our framework for integrating biomedical research data and tools into a unique Web front end. Our framework is applied to the University of Washingtonâs Human Brain Project. SpeciïŹcally, we present solutions to four integration tasks: deïŹnition of complex mappings from relational sources to XML, distributed XQuery processing, generation of heterogeneous output formats, and the integration of heterogeneous data visualization and analysis tools
Theory and Practice of Data Citation
Citations are the cornerstone of knowledge propagation and the primary means
of assessing the quality of research, as well as directing investments in
science. Science is increasingly becoming "data-intensive", where large volumes
of data are collected and analyzed to discover complex patterns through
simulations and experiments, and most scientific reference works have been
replaced by online curated datasets. Yet, given a dataset, there is no
quantitative, consistent and established way of knowing how it has been used
over time, who contributed to its curation, what results have been yielded or
what value it has.
The development of a theory and practice of data citation is fundamental for
considering data as first-class research objects with the same relevance and
centrality of traditional scientific products. Many works in recent years have
discussed data citation from different viewpoints: illustrating why data
citation is needed, defining the principles and outlining recommendations for
data citation systems, and providing computational methods for addressing
specific issues of data citation.
The current panorama is many-faceted and an overall view that brings together
diverse aspects of this topic is still missing. Therefore, this paper aims to
describe the lay of the land for data citation, both from the theoretical (the
why and what) and the practical (the how) angle.Comment: 24 pages, 2 tables, pre-print accepted in Journal of the Association
for Information Science and Technology (JASIST), 201
Storage Solutions for Big Data Systems: A Qualitative Study and Comparison
Big data systems development is full of challenges in view of the variety of
application areas and domains that this technology promises to serve.
Typically, fundamental design decisions involved in big data systems design
include choosing appropriate storage and computing infrastructures. In this age
of heterogeneous systems that integrate different technologies for optimized
solution to a specific real world problem, big data system are not an exception
to any such rule. As far as the storage aspect of any big data system is
concerned, the primary facet in this regard is a storage infrastructure and
NoSQL seems to be the right technology that fulfills its requirements. However,
every big data application has variable data characteristics and thus, the
corresponding data fits into a different data model. This paper presents
feature and use case analysis and comparison of the four main data models
namely document oriented, key value, graph and wide column. Moreover, a feature
analysis of 80 NoSQL solutions has been provided, elaborating on the criteria
and points that a developer must consider while making a possible choice.
Typically, big data storage needs to communicate with the execution engine and
other processing and visualization technologies to create a comprehensive
solution. This brings forth second facet of big data storage, big data file
formats, into picture. The second half of the research paper compares the
advantages, shortcomings and possible use cases of available big data file
formats for Hadoop, which is the foundation for most big data computing
technologies. Decentralized storage and blockchain are seen as the next
generation of big data storage and its challenges and future prospects have
also been discussed
From XML to XML: The why and how of making the biodiversity literature accessible to researchers
We present the ABLE document collection, which consists of a set of annotated volumes of the Bulletin of the British Museum (Natural History). These follow our work on automating the markup of scanned copies of the biodiversity literature, for the purpose of supporting working taxonomists. We consider an enhanced TEI XML markup language, which is used as an intermediate stage in translating from the initial XML obtained from Optical Character Recognition to the target taXMLit. The intermediate representation allows additional information from external sources such as a taxonomic thesaurus to be incorporated before the final translation into taXMLit
OpenTox predictive toxicology framework: toxicological ontology and semantic media wiki-based OpenToxipedia
<p>Abstract</p> <p>Background</p> <p>The OpenTox Framework, developed by the partners in the OpenTox project (<url>http://www.opentox.org</url>), aims at providing a unified access to toxicity data, predictive models and validation procedures. Interoperability of resources is achieved using a common information model, based on the OpenTox ontologies, describing predictive algorithms, models and toxicity data. As toxicological data may come from different, heterogeneous sources, a deployed ontology, unifying the terminology and the resources, is critical for the rational and reliable organization of the data, and its automatic processing.</p> <p>Results</p> <p>The following related ontologies have been developed for OpenTox: a) Toxicological ontology â listing the toxicological endpoints; b) Organs system and Effects ontology â addressing organs, targets/examinations and effects observed in <it>in vivo</it> studies; c) ToxML ontology â representing semi-automatic conversion of the ToxML schema; d) OpenTox ontologyâ representation of OpenTox framework components: chemical compounds, datasets, types of algorithms, models and validation web services; e) ToxLinkâToxCast assays ontology and f) OpenToxipedia community knowledge resource on toxicology terminology.</p> <p>OpenTox components are made available through standardized REST web services, where every compound, data set, and predictive method has a unique resolvable address (URI), used to retrieve its Resource Description Framework (RDF) representation, or to initiate the associated calculations and generate new RDF-based resources.</p> <p>The services support the integration of toxicity and chemical data from various sources, the generation and validation of computer models for toxic effects, seamless integration of new algorithms and scientifically sound validation routines and provide a flexible framework, which allows building arbitrary number of applications, tailored to solving different problems by end users (e.g. toxicologists).</p> <p>Availability</p> <p>The OpenTox toxicological ontology projects may be accessed via the OpenTox ontology development page <url>http://www.opentox.org/dev/ontology</url>; the OpenTox ontology is available as OWL at <url>http://opentox.org/api/1 1/opentox.owl</url>, the ToxML - OWL conversion utility is an open source resource available at <url>http://ambit.svn.sourceforge.net/viewvc/ambit/branches/toxml-utils/</url></p
A Method for Indexing Biomedical Resources over the Internet
A large number of biomedical resources are publicly available over the Internet. This number grows every day. Biomedical researchers face the problem of locating, identifying and selecting the most appropriate resources according to their interests. Some resource indexes can be found in the Internet, but they only provide information and links related to resources created by the owner institution of each website. In this paper we propose a novel method for extracting information from the literature and create a Resourceome, i.e. an index of biomedical resources (databases, tools and services) in a semi-automatic way. In this approach we consider only the information provided by the abstracts of relevant papers in the area. Building a comprehensive resource index is the first step towards the development of new methodologies for the automatic or semi-automatic construction of complex biomedical workflows which allow combining several resources to obtain higher-level functionalities
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