57,510 research outputs found

    Innovative in silico approaches to address avian flu using grid technology

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    The recent years have seen the emergence of diseases which have spread very quickly all around the world either through human travels like SARS or animal migration like avian flu. Among the biggest challenges raised by infectious emerging diseases, one is related to the constant mutation of the viruses which turns them into continuously moving targets for drug and vaccine discovery. Another challenge is related to the early detection and surveillance of the diseases as new cases can appear just anywhere due to the globalization of exchanges and the circulation of people and animals around the earth, as recently demonstrated by the avian flu epidemics. For 3 years now, a collaboration of teams in Europe and Asia has been exploring some innovative in silico approaches to better tackle avian flu taking advantage of the very large computing resources available on international grid infrastructures. Grids were used to study the impact of mutations on the effectiveness of existing drugs against H5N1 and to find potentially new leads active on mutated strains. Grids allow also the integration of distributed data in a completely secured way. The paper presents how we are currently exploring how to integrate the existing data sources towards a global surveillance network for molecular epidemiology.Comment: 7 pages, submitted to Infectious Disorders - Drug Target

    The AliEn system, status and perspectives

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    AliEn is a production environment that implements several components of the Grid paradigm needed to simulate, reconstruct and analyse HEP data in a distributed way. The system is built around Open Source components, uses the Web Services model and standard network protocols to implement the computing platform that is currently being used to produce and analyse Monte Carlo data at over 30 sites on four continents. The aim of this paper is to present the current AliEn architecture and outline its future developments in the light of emerging standards.Comment: Talk from the 2003 Computing in High Energy and Nuclear Physics (CHEP03), La Jolla, Ca, USA, March 2003, 10 pages, Word, 10 figures. PSN MOAT00

    Polish grid infrastructure for science and research

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    Structure, functionality, parameters and organization of the computing Grid in Poland is described, mainly from the perspective of high-energy particle physics community, currently its largest consumer and developer. It represents distributed Tier-2 in the worldwide Grid infrastructure. It also provides services and resources for data-intensive applications in other sciences.Comment: Proceeedings of IEEE Eurocon 2007, Warsaw, Poland, 9-12 Sep. 2007, p.44

    Smart Grid Communications: Overview of Research Challenges, Solutions, and Standardization Activities

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    Optimization of energy consumption in future intelligent energy networks (or Smart Grids) will be based on grid-integrated near-real-time communications between various grid elements in generation, transmission, distribution and loads. This paper discusses some of the challenges and opportunities of communications research in the areas of smart grid and smart metering. In particular, we focus on some of the key communications challenges for realizing interoperable and future-proof smart grid/metering networks, smart grid security and privacy, and how some of the existing networking technologies can be applied to energy management. Finally, we also discuss the coordinated standardization efforts in Europe to harmonize communications standards and protocols.Comment: To be published in IEEE Communications Surveys and Tutorial

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    The Motivation, Architecture and Demonstration of Ultralight Network Testbed

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    In this paper we describe progress in the NSF-funded Ultralight project and a recent demonstration of Ultralight technologies at SuperComputing 2005 (SC|05). The goal of the Ultralight project is to help meet the data-intensive computing challenges of the next generation of particle physics experiments with a comprehensive, network-focused approach. Ultralight adopts a new approach to networking: instead of treating it traditionally, as a static, unchanging and unmanaged set of inter-computer links, we are developing and using it as a dynamic, configurable, and closely monitored resource that is managed from end-to-end. Thus we are constructing a next-generation global system that is able to meet the data processing, distribution, access and analysis needs of the particle physics community. In this paper we present the motivation for, and an overview of, the Ultralight project. We then cover early results in the various working areas of the project. The remainder of the paper describes our experiences of the Ultralight network architecture, kernel setup, application tuning and configuration used during the bandwidth challenge event at SC|05. During this Challenge, we achieved a record-breaking aggregate data rate in excess of 150 Gbps while moving physics datasets between many sites interconnected by the Ultralight backbone network. The exercise highlighted the benefits of Ultralight's research and development efforts that are enabling new and advanced methods of distributed scientific data analysis
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