13,296 research outputs found
Identifying and responding to people with mild learning disabilities in the probation service
It has long been recognised that, like many other individuals, people with learningdisabilities find their way into the criminal justice system. This fact is not disputed. Whathas been disputed, however, is the extent to which those with learning disabilities arerepresented within the various agencies of the criminal justice system and the ways inwhich the criminal justice system (and society) should address this. Recently, social andlegislative confusion over the best way to deal with offenders with learning disabilities andmental health problems has meant that the waters have become even more muddied.Despite current government uncertainty concerning the best way to support offenders withlearning disabilities, the probation service is likely to continue to play a key role in thesupervision of such offenders. The three studies contained herein aim to clarify the extentto which those with learning disabilities are represented in the probation service, toexamine the effectiveness of probation for them and to explore some of the ways in whichprobation could be adapted to fit their needs.Study 1 and study 2 showed that around 10% of offenders on probation in Kent appearedto have an IQ below 75, putting them in the bottom 5% of the general population. Study 3was designed to assess some of the support needs of those with learning disabilities in theprobation service, finding that many of the materials used by the probation service arelikely to be too complex for those with learning disabilities to use effectively. To addressthis, a model for service provision is tentatively suggested. This is based on the findings ofthe three studies and a pragmatic assessment of what the probation service is likely to becapable of achieving in the near future
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Co-design As Healing: Exploring The Experiences Of Participants Facing Mental Health Problems
This thesis is an exploration of the healing role of co-design in mental health. Although co-design projects conducted within mental health settings are rising, existing literature tends to focus on the object of design and its outcomes while the experiences of participants per se remain largely unexplored. The guiding research question of this study is not how we design things that improve mental health, but how co-designing, as an act, might do so.
The thesis presents two projects that were organized in collaboration with the mental health charity Islington Mind and the Psychosis Therapy Project (PTP) in London.
The project at Islington Mind used a structured design process inviting participants to design for wellbeing. A case study analysis provides insights on how participants were impacted, summarizing key challenges and opportunities.
The design at PTP worked towards creating a collective brief in an emergent fashion, finally culminating in a board game. The experiences of participants were explored through Interpretative Phenomenological Analysis (IPA), using semi-structured interview data. The analysis served to identify key themes characterising the experience of co-design such as contributing, connecting, thinking and intentioning. In addition, a mixed-methods analysis of questionnaires and interview data exploring participants' wellbeing, showed that all participants who engaged fairly consistently in the project improved after the project ended, although some participants' scores returned to baseline six months later.
Reflecting on both projects, an approach to facilitation within mental health is outlined, detailing how the dimensions of weaving and layered participation, nurturing mattering and facilitating attitudes interlace. This contribution raises awareness of tacit dimensions in the practice of facilitation, articulating the nuances of how to encourage and sustain meaningful and ethical engagement and offering insights into a range of tools. It highlights the importance of remaining reflexive in relation to attitudes and emotions and discusses practical methodological and ethical challenges and ways to resolve them which can be of benefit to researchers embarking on a similar journey.
The thesis also offers detailed insights on how methodologies from different fields were integrated into a whole, arguing for transparency and reflexivity about epistemological assumptions, and how underlying paradigms shift in an interdisciplinary context.
Based on the overall findings, the thesis makes a case for considering design as healing (or a designerly way of healing), highlighting implications at a systems, social and individual level. It makes an original contribution to our understanding of design, highlighting its healing character, and proposes a new way to support mental health. The participants in this study not only had increased their own wellbeing through co-designing, but were also empowered and contributed towards healing the world. Hence, the thesis argues for a unique, holistic perspective of design and mental health, recognizing the interconnectedness of the individual, social and systemic dimensions of the healing processes that are ignited
Clinicians' experiences of using the MCA (2005) with people with intellectual disabilities
Section A is a narrative synthesis of the empirical literature of professionals’ knowledge of the
MCA and how they apply it when working with people with intellectual disabilities (ID).
Eleven papers were identified for inclusion in this review. Four themes, with subthemes, were
identified: ‘processes involved’, ‘working with complexity’, ‘knowledge gaps and variability’
and ‘assessor needs’. Methodological strengths and weaknesses are also considered. Findings
are discussed in relation to clinical implications and recommendations for future research are
outlined.
Section B is an empirical study using Interpretative Phenomenological Analysis to explore the
experiences of clinicians using the MCA (2005) with people with ID to assess capacity to
consent to sex. Eight clinicians, who had completed between 2 and 40-50 (mode=2) MCA
assessments regarding consent to sex. Three superordinate themes, with subthemes, are
outlined and discussed in relation to the existing literature. Limitations, clinical implications
and areas of future research are considered
Underwater optical wireless communications in turbulent conditions: from simulation to experimentation
Underwater optical wireless communication (UOWC) is a technology that aims to apply high speed optical wireless communication (OWC) techniques to the underwater channel. UOWC has the potential to provide high speed links over relatively short distances as part of a hybrid underwater network, along with radio frequency (RF) and underwater acoustic communications (UAC) technologies. However, there are some difficulties involved in developing a reliable UOWC link, namely, the complexity of the channel. The main focus throughout this thesis is to develop a greater understanding of the effects of the UOWC channel, especially underwater turbulence. This understanding is developed from basic theory through to simulation and experimental studies in order to gain a holistic understanding of turbulence in the UOWC channel.
This thesis first presents a method of modelling optical underwater turbulence through simulation that allows it to be examined in conjunction with absorption and scattering. In a stationary channel, this turbulence induced scattering is shown to cause and increase both spatial and temporal spreading at the receiver plane. It is also demonstrated using the technique presented that the relative impact of turbulence on a received signal is lower in a highly scattering channel, showing an in-built resilience of these channels. Received intensity distributions are presented confirming that fluctuations in received power from this method follow the commonly used Log-Normal fading model. The impact of turbulence - as measured using this new modelling framework - on link performance, in terms of maximum achievable data rate and bit error rate is equally investigated.
Following that, experimental studies comparing both the relative impact of turbulence induced scattering on coherent and non-coherent light propagating through water and the relative impact of turbulence in different water conditions are presented. It is shown that the scintillation index increases with increasing temperature inhomogeneity in the underwater channel. These results indicate that a light beam from a non-coherent source has a greater resilience to temperature inhomogeneity induced turbulence effect in an underwater channel. These results will help researchers in simulating realistic channel conditions when modelling a light emitting diode (LED) based intensity modulation with direct detection (IM/DD) UOWC link.
Finally, a comparison of different modulation schemes in still and turbulent water conditions is presented. Using an underwater channel emulator, it is shown that pulse position modulation (PPM) and subcarrier intensity modulation (SIM) have an inherent resilience to turbulence induced fading with SIM achieving higher data rates under all conditions. The signal processing technique termed pair-wise coding (PWC) is applied to SIM in underwater optical wireless communications for the first time. The performance of PWC is compared with the, state-of-the-art, bit and power loading optimisation algorithm. Using PWC, a maximum data rate of 5.2 Gbps is achieved in still water conditions
Uso de las histonas circulantes y sus modificaciones post-traduccionales como biomarcadores en sepsis y shock séptico
La sepsis es una afección potencialmente mortal causada por una respuesta anormal del huésped a una infección, produciendo respuestas fisiológicas alteradas que dañan los propios tejidos del paciente y pueden provocar disfunción orgánica e incluso la muerte. Asimismo, algunos pacientes sépticos progresan a shock séptico, caracterizado por alteraciones circulatorias, celulares y metabólicas sustanciales que aumentan el riesgo de mortalidad. A pesar de que la sepsis se caracteriza por un mal funcionamiento del sistema inmunológico, lo que a su vez conduce a una respuesta inmune alterada e inmunosupresión, la alta complejidad de la fisiopatologÃa de la sepsis requiere una mayor investigación para comprender las respuestas inmunes que ocurren durante la sepsis. Asimismo, las histonas extracelulares circulantes han ganado relevancia como mediadores citotóxicos en la sepsis, ya que actúan como patrones moleculares asociados a daño, que inducen estrés oxidativo y activan el inflamasoma NLRP3. Estos mecanismos median la activación de la piroptosis, un mecanismo de muerte celular programada que produce inflamación mediante la expresión de IL-18, IL-1β and IL-1α. Sin embargo, a pesar de la evidencia de activación del inflamasoma en las células inmunes durante la sepsis, se desconoce si las histonas extracelulares son capaces de activar los inflamasomas endoteliales y sus consecuencias. En este trabajo destacamos el papel previamente desconocido de las histonas extracelulares, mediando la activación del inflamasoma NLRP3 y la piroptosis en las células endoteliales, contribuyendo a la disfunción endotelial y la desregulación de la respuesta inmune mediada por el endotelio. Asimismo, también demostramos cómo la acetilación de histonas disminuye la activación de la piroptosis. Además, demostramos que la piroptosis se produce en pacientes con shock séptico y los niveles de histonas circulantes se correlacionan con la expresión de citoquinas proinflamatorias y citoquinas piroptóticas, la liberación de factores de adhesión endotelial y la gravedad de la enfermedad. Proponemos la piroptosis mediada por histonas como un nuevo objetivo para desarrollar intervenciones clÃnicas. De manera similar, hemos analizado las respuestas inmunorelacionadas que ocurren durante las primeras etapas de la sepsis con el objetivo de proporcionar nuevos datos comparando las cantidades de citoquinas, inmunomoduladores y otros mediadores endoteliales en pacientes crÃticamente enfermos no sépticos, sépticos y de shock séptico. Nuestro enfoque ayudará a caracterizar rápidamente las respuestas inmunes alteradas en pacientes sépticos y de shock séptico ingresados en la Unidad de Cuidados Intensivos. Finalmente analizamos el papel de la metilación del ADN en el control del sistema inmune séptico. Nuestros resultados demostraron el papel central de la metilación del ADN modulando la respuesta molecular en los pacientes de shock séptico y contribuyendo a la inmunosupresión, a través de la alteración de los patrones de metilación de los promotores de IL-10 y TREM-2.Sepsis is a life-threatening condition caused by an abnormal host response to an infection that produce altered physiological responses which damages own tissues of the patient and can result in organ dysfunction and in some cases death. Likewise, a subset of septic patients progresses to septic shock, characterized by substantial circulatory, cellular and metabolic abnormalities, which substantially increase the risk of mortality. Sepsis is characterized by a malfunction of the immune system and it can lead to an altered immune response and immunosuppression. Moreover, the high complexity of the pathophysiology of sepsis requires of further investigation to characterize the immune responses in sepsis and septic shock. Likewise, circulating extracellular histones have gained relevance as cytotoxic mediators in sepsis pathophysiology, since they act as damage-associated molecular patterns, which induce oxidative stress and activate NLRP3 inflammasome. Subsequently, inflammasome mediates pyroptosis activation, a programmed cell death mechanism that produces inflammation through the release of IL-18, IL-1β and IL-1α. However, despite inflammasome activation may occur in immune cells during sepsis, it is unknown if this process also takes place in endothelial cells and particularly whether extracellular histones are capable of activating endothelial inflammasomes and their consequences. In this work we highlight a previously unknown role for extracellular histones, that mediates the activation of NLRP3 inflammasome and pyroptosis in endothelial cells by contributing to endothelial dysfunction and the dysregulation of the immune response mediated by endothelium. Likewise, we demonstrated how histone acetylation decreases pyroptosis activation. Furthermore, we show how pyroptosis occurs in septic shock patients and how circulating histone levels correlate with the expression of pro-inflammatory and pyroptotic cytokines, the release of endothelial adhesion factors and septic shock severity. We propose histone-mediated pyroptosis as a new target to develop clinical interventions. Similarly, we have analyzed the immune-related responses occurring during the early stages of sepsis with the aim of providing new data by comparing the amounts of cytokines, immune modulators and other endothelial mediators in critically-ill non-septic patients, septic and septic shock patients. Our approach will help to rapidly characterize the altered immune responses in septic and septic shock patients admitted in the Intensive Care Unit. Finally, we also analyzed the role of DNA methylation in the control of septic immune system. Our results demonstrated the central role of DNA methylation modulating the molecular response in septic shock patients and contributing to immunosuppression, through the alteration of DNA methylation patterns of IL-10 and TREM2 promoters
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Introduction. Resource Pack to Support Remote Learning
In response to the challenge to education systems presented by the global COVID-19 pandemic, UNICEF and the World Bank have created a set of seven Resource Packs about remote learning. The packs are designed to support government officials and staff in national and international agencies tasked with designing and implementing effective remote learning opportunities for children in development and humanitarian contexts.
Remote learning is the process of teaching and learning performed at a distance. Rather than having learners meet their teachers in person, learners are distanced from their teacher and possibly their peers as well. One of the consequences of COVID-19 is that almost every country has had to put in place remote learning programmes. The packs are therefore designed primarily to help you to enhance and improve the effectiveness of existing remote learning programmes.
This introductory Resource Pack considers the key elements of a ‘pedagogy-first’ approach to remote learning, starting with the learner and learning, then considering technology options and your programmes’ broader approach to supporting learning. It discusses some of the most common considerations that remote programmes often overlook but which, if carefully considered, can lead to improved learning for more children
The alignment of the open innovation process and the project lifecycle
Purpose
This research study aims to develop an alignment model based on a literature review that explains the association between the construction project lifecycle and the innovation process, while considering the integration of all stakeholders in the process in an open innovation context.
Design/methodology/approach
The authors conduct an extensive review of the open innovation and the construction project management literature to establish an alignment model through the investigation and analysis of the current scholarly contributions. This research study is based on a theoretical framework; thus, it has not utilized any primary data. Moreover, data collected for this research study was obtained from reliable literary sources.
Findings
The study presents an alignment model that has uncovered a strong correlation between project activities, stakeholder integration and innovation. The authors revealed critical factors that require an enhanced inter- and intra-collaboration between the various stakeholders and team members to achieve an effective innovation process in a project context.
Originality/value
This study provides a previously unexplored alignment between the project lifecycle and the innovation process. It signifies several critical factors that influence the effectiveness of innovations in a construction project context. Furthermore, it identifies different zones and knowledge transfer gates that necessitate proper leadership, stakeholder integration and team dynamics throughout the project lifecycle
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Privacy-aware Smart Home Interface Framework
Smart home user interfaces are pervasive and shared by multiple users who occupy the space. Therefore, they pose a risk to interpersonal privacy of occupants because an individual’s sensitive information can be leaked to other co-occupants (information privacy), or they can be disturbed by intrusions into their personal space (physical privacy) when the co-occupant interacts with the smart home user interfaces. This thesis hypothesises that interpersonal privacy violations can be mitigated by adapting the user interface layer and presents insights into how to achieve usable user interface adaptation to mitigate or minimise interpersonal privacy violations in smart homes.
The thesis reports two case studies and two user studies. The first case study identifies the key characteristics needed to model the rich context of interpersonal privacy violations scenarios. Then it presents knowledge representation models that are required to represent the identified characteristics and evaluates them for adequacy in modelling the context information of interpersonal privacy violation scenarios. The second case study presents a software architecture and a set of algorithms that can detect interpersonal privacy violations and generate usable user interface adaptations. Then it evaluates the architecture and the algorithms for adequacy in generating usable privacy-aware user interface adaptations. The first user study (N=15) evaluates the usability of the adaptive user interfaces generated from the framework where storyboards were used as the stimulant. Extending the findings from the usability study and expanding the coverage of example scenarios, the second user study (N=23) evaluates the overall user experience of the adaptive user interfaces, using video prototypes as the stimulant.
The research demonstrates that the characteristics identified, and the respective knowledge representation models adequately captured the context of interpersonal privacy violation scenarios. Furthermore, the software architecture and the algorithms could detect possible interpersonal privacy violations and generate usable user interface adaptations to mitigate them. The two user studies demonstrate that the adaptive user interfaces, when used in appropriate situations, were a suitable solution for addressing interpersonal privacy violations while providing high usability and a positive user experience. The thesis concludes by providing recommendations for developing privacy-aware user interface adaptations and suggesting future work that can extend this research
Adaptive task selection using threshold-based techniques in dynamic sensor networks
Sensor nodes, like many social insect species, exist in harsh environments in large groups, yet possess very limited amount of resources. Lasting for as long as possible, and fulfilling the network purposes are the ultimate goals of sensor networks. However, these goals are inherently contradictory. Nature can be a great source of inspiration for mankind to find methods to achieve both extended survival, and effective operation. This work aims at applying the threshold-based action selection mechanisms inspired from insect societies to perform action selection within sensor nodes. The effect of this micro-model on the macro-behaviour of the network is studied in terms of durability and task performance quality. Generally, this is an example of using bio-inspiration to achieve adaptivity in sensor networks
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