463,921 research outputs found

    Towards Entity Status

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    Discourse entities are an important construct in computational linguistics. They introduce an additional level of representation between referring expressions and that which they refer to: the level of mental representation. In this thesis, I first explore some semiotic and communication theoretic aspects of discourse entities. Then, I develop the concept of "entity status". Entity status is a meta-variable that collects two dimensions formations about the role that an entity plays a discourse, and management informations about how the entity is created, accessed, and updated. Finally, the concept is applied to two case studies: the first one focusses on the choice of referring expressions in radio news, while the second looks at the conditions under which a discourse entity can be mentioned as a pronoun.DiskursentitĂ€ten sind ein wichtiger Konstrukt in der Computerlinguistik. Sie fĂŒhren eine zusĂ€tzliche ReprĂ€sentationsebene ein zwischen referierenden AusdrĂŒcken, und dem, auf das diese AusdrĂŒcke referieren: die Ebene der mentalen ReprĂ€sentation. In dieser Dissertation erkunde ich zunĂ€chst einige semiotische und kommunikationstheoretische Aspekte von DiskursentitĂ€ten. Danach fĂŒhre ich den Begriff des "EntitĂ€tenstatus" ein. EntitĂ€tenstatus ist eine Meta-Variable, die zwei Dimensionen von Information ĂŒber eine DiskursentitĂ€t vereinigt: Struktur-Informationen ĂŒber die Rolle, die eine EntitĂ€t im Diskurs spielt, und Verwaltungs-Informationen ĂŒber Erstellung, Zugriff und Update. Dieser Begriff wird schlussendlich auf zwei Fallstudien angewendet: die erste Studie konzentriert sich auf die Wahl referierender AusdrĂŒcke in Radionachrichten, wĂ€hrend die zweite Studie die Bedingungen untersucht, in denen eine DiskursentitĂ€t als Pronomen erwĂ€hnt werden kann

    Evaluation in experimental research articles

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    This thesis examines evaluation in experimental research articles in terms of the meanings made and their contribution to the organisation of the articles. After an introduction to the phenomenon of evaluation in Chapter 1, Chapter 2 surveys recent work concerning the process of scientific discovery and the writing of research articles. Chapter 3 returns to evaluation and its place in various theories of discourse, mainly those of Sinclair and of Halliday. The model of evaluation proposed in this thesis is set out in the next three chapters, dealing in turn with the Status, Value and Relevance functions of evaluation. Status is the function of evaluation which bestows entity, assessing along a certain-uncertain parameter. Value bestows quality and assesses along a good-bad parameter. Evaluation of Relevance is meta-discoursal and marks significance. Relevance Markers are identified, which progressively chunk and organise the text. Comparisons between texts analysed for Status, Value and Relevance demonstrate a movement towards the theoretical and an increase in complexity of argument as the sub-discipline under discussion progresses. Chapter 7 investigates the contribution of evaluation towards text structure and notes a number of ways in which discourse units in experimental research articles may be organised. The concluding chapter, Chapter 8, discusses some of the practical and theoretical implications of the work described in the thesis. The Appendix contains the research articles which comprise the corpus

    STATUS HUKUM ASET PERUSAHAAN NEGARA DALAM HUKUM INTERNASIONAL

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    The immunity of state s assets is one of the reason why it has not been easy for private companies to retrieve remedy inforeign disputes. Principles of international law has regulated that a state s asset have immunity unless agreed upon by the state itself. Up until today, there has been no uniformity in determining the status of a state s assets. The legal entity, the government s intervention towards company policies, the nature of the transactions, also the asset s purpose are crucial factors which influence the legal status of the assets in determining whether the assets could be executed or not

    Extended microsatellite analysis in microsatellite stable, MSH2 and MLH1 mutation-negative HNPCC patients: Genetic reclassification and correlation with clinical features

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    Background: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder predisposing to predominantly colorectal cancer (CRC) and endometrial cancer frequently due to germline mutations in DNA mismatch repair (MMR) genes, mainly MLH1, MSH2 and also MSH6 in families seen to demonstrate an excess of endometrial cancer. As a consequence, tumors in HNPCC reveal alterations in the length of simple repetitive genomic sequences like poly-A, poly-T, CA or GT repeats (microsatellites) in at least 90% of the cases. Aim of the Study: The study cohort consisted of 25 HNPCC index patients ( 19 Amsterdam positive, 6 Bethesda positive) who revealed a microsatellite stable (MSS) - or low instable (MSI-L) - tumor phenotype with negative mutation analysis for the MMR genes MLH1 and MSH2. An extended marker panel (BAT40, D10S197, D13S153, D18S58, MYCL1) was analyzed for the tumors of these patients with regard to three aspects. First, to reconfirm the MSI-L phenotype found by the standard panel; second, to find minor MSIs which might point towards an MSH6 mutation, and third, to reconfirm the MSS status of hereditary tumors. The reconfirmation of the MSS status of tumors not caused by mutations in the MMR genes should allow one to define another entity of hereditary CRC. Their clinical features were compared with those of 150 patients with sporadic CRCs. Results: In this way, 17 MSS and 8 MSI-L tumors were reclassified as 5 MSS, 18 MSI-L and even 2 MSI-H ( high instability) tumors, the last being seen to demonstrate at least 4 instable markers out of 10. Among all family members, 87 malignancies were documented. The mean age of onset for CRCs was the lowest in the MSI-H-phenotyped patients with 40.5 +/- 4.9 years (vs. 47.0 +/- 14.6 and 49.8 +/- 11.9 years in MSI-L- and MSS-phenotyped patients, respectively). The percentage of CRC was the highest in families with MSS-phenotyped tumors (88%), followed by MSI-L-phenotyped ( 78%) and then by MSI-H-phenotyped (67%) tumors. MSS tumors were preferentially localized in the distal colon supposing a similar biologic behavior like sporadic CRC. MSH6 mutation analysis for the MSI-L and MSI-H patients revealed one truncating mutation for a patient initially with an MSS tumor, which was reclassified as MSI-L by analyzing the extended marker panel. Conclusion: Extended microsatellite analysis serves to evaluate the sensitivity of the reference panel for HNPCC detection and permits phenotype confirmation or upgrading. Additionally, it confirms the MSS status of hereditary CRCs not caused by the common mutations in the MMR genes and provides hints to another entity of hereditary CRC. Copyright (C) 2004 S. Karger AG, Basel

    The Trouble with Environmental Values

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    If we are to assess whether our attitudes towards nature are morally, aesthetically or in any other way appropriate or inappropriate, then we will need to know what those attitudes are. Drawing on the works of Katie McShane, Alan Holland and Christine Swanton, I challenge the common assumption that to love, respect, honour, cherish or adopt any other sort of pro-attitude towards any natural X simply is to value X in some way and to some degree. Depending on how one interprets ‘value’, that assumption is, I contend, either false or vacuous. I argue that to assess the appropriateness of a person’s pro-attitudes towards a natural entity one must in some cases appeal to the concepts of status and/or bond, and not just that of value. To develop my argument, I appeal to the works of two nature writers – Robert Macfarlane and J. A. Baker

    The role of pitch accent type in interpreting information status

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    The present study set out to pin down the role of four pitch accents, fall (H*L), rise-fall (L*HL), rise (L*H), fall-rise (H*LH), as well as deaccentuation, in interpreting new vs. given information in British English by the eyetracking paradigm. The pitch accents in question were claimed to convey information status in theories of English intonational meaning. There is, however, no consensus on the postulated roles of these pitch accents. Results clearly show that pitch accent type can and does matter when interpreting information status. The effects can be reflected in the mean proportions of fixations to the competitor in a selected time window. These patterns are also present in proportions of fixations to the target but to a lesser extent. Interestingly, the effects of pitch accent types are also reflected in how fast the participants could adjust their decision as to which picture to move before the name of the picture was fully revealed. For example, when the competitor was a given entity, the proportion of fixations to the competitor increased initially in most accent conditions in the first as a result of subjects' bias towards a given entity, but started to decrease substantially earlier in the H*L condition than in the L*H and deaccentuation conditions

    A systematic approach to cancer: evolution beyond selection.

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    Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems. Cognition based evolution is suggested as an alternative approach to cancer development and progression in which neoplastic cells of differing karyotypes and cellular lineages are assessed as self-referential agencies with purposive participation within tissue microenvironments. As distinct self-aware entities, neoplastic cells occupy unique participant/observer status within tissue ecologies. In consequence, neoplastic proliferation by clonal lineages is enhanced by the advantaged utilization of ecological resources through flexible re-connection with progenitor evolutionary stages

    The implications of stakeholders' perceptions of land for sustainable land use management in NE Ghana

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    There are negative implications of changes in stakeholders traditional land perceptions for sustainable land use and management in north-east Ghana. In African tenurial systems, land use was based on a local mystical view of the environment and stakeholders broad-based knowledge of the local environments. These led to sustainable resource use and management. However, in the context of current political ecology of north-east Ghana as induced by increased population growth, urbanisation, the market economy, changes in religious beliefs, and government land policies, stakeholders understandings of land have acquired even greater importance in issues of sustainable land resource use and management. A mixed methodological approach, combining both qualitative and quantitative data gathering techniques for information on stakeholders land perceptions, was used to analyse their implications for sustainable land use and management. Changes in the dynamics of stakeholders perceptions of land are partly responsible for the current state of land and environmental degradation in north-east Ghana. Policies aimed at ensuring sustainable land use and environmental management must focus on those traditional land perceptions, which encourage environmental sustainabilit

    Law’s Entities: Complexity, Plasticity and Justice

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    In the early twenty-first century, and looking beyond it, the landscapes of law’s operation are characterised by a growing degree of complexity and pressure. Law is called upon to coordinate relations in a world facing a significant complexities produced by a convergence between bio-technological developments capable of transforming the very conditions of life itself, climate-change pressures and the threat of the collapse of bio-diversity and eco-systems, and intensifying global inter-dependencies deepening vulnerability on a whole set of scales and measures

    The Sui Generis Problem in Plato's Timaeus

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    In the Timaeus, Plato tells the story of a divine craftsman who, using the world of intelligibles as a model, produces a living and orderly universe from the pre-existing physical elements. The Demiurge in the cosmological narrative has at various times been identified by interpreters of Plato with the model, the product, or even simultaneously both. I intend to argue that there is a strong basis for Plato’s cosmology to be structurally triadic, that is, between a distinct model, cause, and product. As such, the Demiurge, identified with the cause, can be interpreted as ontologically distinct from his product, the World-soul, as well as the model, the Forms. Thus, the Demiurge must be Sui Generis, ontologically distinct from model as well as product
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