770 research outputs found

    Model-driven Techniques for Data Model Synthesis

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    Multimodal discourse on online newspaper home pages: A social-semiotic perspective

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    In a short space of time, online newspapers have emerged to play an important role in the institutional construction of ‘news’ and the mass mediation of information. The home pages of online newspapers feature short verbal texts, and communicate using language, image, layout, colour, and other semiotic resources: they communicate multimodally. This thesis examines the multimodal discourse of three English-language online newspapers: the Bangkok Post (Thailand), the English-language edition (translated from Chinese) of the People’s Daily (China), and the Sydney Morning Herald (Australia). Between February, 2002 and April, 2006, three data collections were made (February-April, 2002; September-November, 2005; January-April, 2006) using a five-day ‘constructed week’ method. The main corpus was 15 home pages from each newspaper (five per collection per newspaper), but the total corpus (including other pages from each newspaper) was 603 web pages. Two senior editors (one each from the Bangkok Post and the Sydney Morning Herald) were interviewed. The multimodal discourse of the home pages was analysed using tools from Systemic Functional Multimodal Discourse Analysis (SF-MDA), and a ‘visual grammar’ of home pages building on the work of Kress & van Leeuwen (1996) was developed. In addition, a rank scale for online newspapers was proposed, and limitations of applying the tool of rank scale to this corpus were identified. An emerging genre - the headline-plus-lead-plus-hyperlink newsbite - was identified, and the design of newsbites on the home page of the Sydney Morning Herald and the evolution of their design over time was analysed. The use of images on the home pages in the corpus was analysed, and the increasing use of thumbnail images in the Sydney Morning Herald - particularly close-up thumbnails of faces - was investigated in further depth. The visual design of online newspaper home pages and the news texts appearing on them are an evolution of print news genres and their design practices. Newsbites and headline-only newsbits are verbally short, so the authors of newspaper home pages are forced to rely increasingly on visual communication in order to position stories and readers, and to communicate the values of the news institution on the home page as mediated by the screen. Thumbnail images are evolving as a new form of punctuation on some home pages, and this may be a short-lived, or an emerging historical trend in the development of punctuation, at least in online environments. Overall, online newspaper home pages are tending towards shorter texts, which communicate in novel ways. These short texts cannot communicate the values and ideology of news institutions in the way that extended verbal texts have done for centuries, yet this function of news texts remains important to the construction and maintenance of a readership, and therefore crucial to the home page of a newspaper. As a result, news institutions express values visually in their design of newspaper home pages. As readers become familiar with the meanings of online news design, they become adept at reading and understanding short stories within these multimodally-construed frames of reference. Ideology is increasingly fragmented on shorter timescales, but expressed over longer timescales in a hypermedia environment that affords and extends many of the pre-existing multimodal features of print newspaper discourse

    Multimodal discourse on online newspaper home pages: A social-semiotic perspective

    Get PDF
    In a short space of time, online newspapers have emerged to play an important role in the institutional construction of ‘news’ and the mass mediation of information. The home pages of online newspapers feature short verbal texts, and communicate using language, image, layout, colour, and other semiotic resources: they communicate multimodally. This thesis examines the multimodal discourse of three English-language online newspapers: the Bangkok Post (Thailand), the English-language edition (translated from Chinese) of the People’s Daily (China), and the Sydney Morning Herald (Australia). Between February, 2002 and April, 2006, three data collections were made (February-April, 2002; September-November, 2005; January-April, 2006) using a five-day ‘constructed week’ method. The main corpus was 15 home pages from each newspaper (five per collection per newspaper), but the total corpus (including other pages from each newspaper) was 603 web pages. Two senior editors (one each from the Bangkok Post and the Sydney Morning Herald) were interviewed. The multimodal discourse of the home pages was analysed using tools from Systemic Functional Multimodal Discourse Analysis (SF-MDA), and a ‘visual grammar’ of home pages building on the work of Kress & van Leeuwen (1996) was developed. In addition, a rank scale for online newspapers was proposed, and limitations of applying the tool of rank scale to this corpus were identified. An emerging genre - the headline-plus-lead-plus-hyperlink newsbite - was identified, and the design of newsbites on the home page of the Sydney Morning Herald and the evolution of their design over time was analysed. The use of images on the home pages in the corpus was analysed, and the increasing use of thumbnail images in the Sydney Morning Herald - particularly close-up thumbnails of faces - was investigated in further depth. The visual design of online newspaper home pages and the news texts appearing on them are an evolution of print news genres and their design practices. Newsbites and headline-only newsbits are verbally short, so the authors of newspaper home pages are forced to rely increasingly on visual communication in order to position stories and readers, and to communicate the values of the news institution on the home page as mediated by the screen. Thumbnail images are evolving as a new form of punctuation on some home pages, and this may be a short-lived, or an emerging historical trend in the development of punctuation, at least in online environments. Overall, online newspaper home pages are tending towards shorter texts, which communicate in novel ways. These short texts cannot communicate the values and ideology of news institutions in the way that extended verbal texts have done for centuries, yet this function of news texts remains important to the construction and maintenance of a readership, and therefore crucial to the home page of a newspaper. As a result, news institutions express values visually in their design of newspaper home pages. As readers become familiar with the meanings of online news design, they become adept at reading and understanding short stories within these multimodally-construed frames of reference. Ideology is increasingly fragmented on shorter timescales, but expressed over longer timescales in a hypermedia environment that affords and extends many of the pre-existing multimodal features of print newspaper discourse

    Glass Ceramics Composites Fabricated from Coal Fly Ash and Waste Glass

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    Great quantities of coal ash are produced in thermal power plants which present a double problem to the society: economical and environmental. This waste is a result of burning of coal at temperatures between 1100-14500C. Fly ash available as fine powder presents a source of important oxides SiO2, Al2O3, Fe2O3, MgO, Na2O, but also consist of small amount of ecologically hazardous oxides such as Cr2O3, NiO, MnO. The combination of the fly ash with waste glass under controlled sintering procedure gave bulk glass-ceramics composite material. The principle of this procedure is presented as a multi barrier concept (1). Many researches have been conducted the investigations for utilization of fly ash as starting material for various glass–ceramics production (2-4). Using waste glass ecologically hazardous components are fixed at the molecular level in the silicate phase and the fabricated new glass-ceramic composites possess significantly higher mechanical properties. The aim of this investigation was to fabricate dense glass ceramic composites using fly ash and waste glass with the potential for its utilization as building material

    Elucidating the Cellular Physiology Associated with the Herbicide (Glyphosate) Resistance and Tolerance in Agricultural Weeds Using Metabolomics Approach

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    Current management practices overemphasizes on herbicides to manage weeds in crop production systems. However, indiscriminate use of herbicides to manage weeds has resulted in the development of resistance in several weed biotypes. Over-application on glyphosate to manage weeds in cropping system that uses RoundUp® Ready™ trait has resulted in the dominance of glyphosate resistant weeds across cropping systems. Glyphosate resistance is an important, economically unviable and rapidly escalating problem across agricultural production systems. To combat herbicide resistance, current recommendations advocate for changes in chemical and cultural practices of weed control, including rotation of herbicide regimen with herbicides with alternate modes of action, and formulation of cultural practices that would penalize the expression of resistance. Some of the bottlenecks in practicing these approaches are the current lack of knowledge about the weed cellular physiology that ensues resistance expression, the potential metabolic cost associated with this resistance expression, and the occurrence of compensatory pathways that could defray the cost of resistance expression. Adopting an alternate herbicide regimen without an understanding of the cellular physiology of resistance expression would result in the development of herbicide cross resistance in weeds, which would further aggravate the problem. To bridge this knowledge-gap, in this studies, metabolomics approach and complementary biochemical analyses were used to track the changes in cellular metabolism in weed species and biotypes that are resistant and naturally tolerant to glyphosate. In Ipomoea lacunosa, non-targeted metabolic profiling captured the differences in metabolic pool levels in two biotypes (WAS and QUI) with contrasting glyphosate tolerance (GR50 = 151 g ae ha-1 and 59 g ae ha-1). Metabolic profiling followed by pathway topological analysis captured innate metabolic differences (22 significantly different metabolites) between WAS and QUI biotypes. Despite the glyphosate dose being half the GR50 rate, shikimic acid accumulation was observed in both the biotypes. However, regardless of EPSPS inhibition, no changes in aromatic amino abundance was observed in the QUI biotype and WAS biotype, indicating their tolerance to the glyphosate. The results from this study implies that though I. lacunosa is tolerant to glyphosate, glyphosate exposure induces cellular metabolic perturbations. The varying tolerance to glyphosate could thus be due to physiological and metabolic adaptations between the different biotypes. Following through, metabolite and biochemical profiling of a susceptible (S) and resistant (R) biotype of Amaranthus palmeri identified physiological perturbations induced by glyphosate in both the biotypes at 8 and 80 hours after treatment (HAT). Compared to the S-biotype, the R-biotype had a 17 fold resistance to the normal field recommended rate of glyphosate. At 8HAT, shikimic acid accumulation in both S- and R-biotypes in response to glyphosate application indicated that the R-biotype was equally susceptible to glyphosate toxicity. The metabolite pool of glyphosate-treated R-biotype was similar to that of the water-treated (control) S and R-biotype, indicating physiological recovery at 80 HAT. A key finding from this study is that despite being resistant to glyphosate, Palmer amaranth biotypes initially sustained metabolic perturbation from glyphosate. However, what differentiates them from the susceptible biotypes is their ability to recover from the glyphosate induced metabolic disruptions. In response to glyphosate, glyphosate-treated R-biotype had lower reactive oxygen species (ROS) damage, higher ROS scavenging activity, and higher levels of secondary compounds of the shikimate pathway, leading to the finding that elevated anti-oxidant mechanisms in A. palmeri complements the resistance conferred due to increased EPSPS copy number. Furthermore, metabolite dynamics in response to glyphosate application studied using stable isotope resolved metabolomics revealed that despite glyphosate toxicity induced decrease in soluble proteins, a proportional increase in both 14N and 15N amino acids was observed in the susceptible plants. This indicates that following glyphosate treatment, a potential increase in de novo amino acid synthesis, coupled with a lower protein synthesis, and higher protein catabolism is observed in the S-biotype. In contrast, the R-biotype, though affected by glyphosate initially, had higher de novo amino acid synthesis without significant disruptions. Moreover, it is to be noted that although the initial assimilation of inorganic nitrogen to organic forms is less affected in the S-biotype than the R-biotype by glyphosate, amino acid biosynthesis downstream of glutamine is disproportionately disrupted. It is thus concluded that the herbicide-induced amino acid abundance in the S-biotype is contributed to by both protein catabolism, and de novo synthesis of amino acids such as glutamine and asparagine. Due to variability in the genetic makeup of populations, each biotype would exhibit different physiological manifestations when exposed to the same rate of glyphosate. Biochemical and metabolic profiling of five different Palmer amaranth biotypes indicated that both the S- and R-biotypes had comparable innate phytochemical profile and similar abundance in flavonoids and phenolic. However, compared to the S-biotypes, the R-biotypes had innately higher anti-oxidant capacity, and the antioxidant capacity was observed to correlate with the GR50 such that antioxidant capacity increased with increasing GR50. Upon treatment with glyphosate, there were significant alterations in the metabolic pool levels across all biotypes. After glyphosate treatment, the content of total phenolic and flavonoids decrease in S-biotypes, whereas the abundance of these metabolites either remained the same, or increased in the R-biotypes. These results indicate that antioxidant capacity is a complementary function aiding in conferring glyphosate resistance and the phytochemistry and the antioxidant capacity is partly induced after glyphosate application, rather than being constitutively expressed. Overall, these study demonstrates that, across biotypes and species, irrespective of their degree of resistance/tolerance, glyphosate not only perturbs shikimate pathway, but also a multitude of other metabolic pathways that are independent of shikimate pathway (secondary toxic effects) as early as eight hours after treatment. While in the susceptible biotypes these metabolic perturbations result in rapid cellular damage, these metabolic perturbations fail to translate to cellular damage in the resistant biotypes. The results indicate that the resistance of A. palmeri biotypes that were used in these studies partially stems from their ability to rapidly induce the production of phenylpropanoids soon after the glyphosate application. This induction of phytochemicals could quench the reactive molecules that are initially produced during the secondary metabolic perturbations, and would thus complement the glyphosate resistance in Amaranthus biotypes conferred by EPSPS gene amplification

    Groundwater management in land administration: a spatio-temporal perspective

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    Although the use of land and water is intertwined, specifics for groundwater management are not effectively dealt with in the laws and other institutional mechanisms related to land. Provisions for groundwater aspects in land management are there, but with a focus on the land itself. Land rights and restrictions are more or less static, lacking enough flexibility to incorporate the relatively short interval spatio-temporal dynamics of groundwater resources in the land management and regulation mechanisms. This leads to a gap between the scientific inputs and policy-decision making. The paper suggests the adaptation of a spatial information science based approach to bridge the gap between the technical and administrative aspects of groundwater management. The land administration domain model (LADM) provides a basic set of elements capable of supporting the inclusion of basic groundwater modeling elements into land administration, making it possible to create a support system for the management of land and water. For this purpose, spatial and temporal dimensions under the legal-administrative and spatial unit components of the standard LADM model are reviewed. The paper shows that the advancement of spatial technologies is capable of providing solutions for global issues such as groundwater resource management. As a first step towards implementation of these technologies, it is essential to include spatio-temporal dynamics properly in the standard data models. Increased knowledge of the behaviour of groundwater resources, supported by a technical system built on a land administration counterpart, could help improve greater sustainability in the use of such resources. Considering the specific arrangements of rights, parties and spatial units this could, if desired, also provide the base for a regulated private market in groundwater assets. Further research will be needed to fully operationalize and implement such data models, which ultimately could produce outputs at case study level which can help to formulate policies regarding natural resources more on the basis of technical inputs

    2016 IMSAloquium, Student Investigation Showcase

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    Welcome to the twenty-eighth year of the Student Inquiry and Research Program (SIR)! This is a program that is as old as IMSA. The SIR program represents our unending dedication to enabling our students to learn what it is to be an innovator and to make contributions to what is known on Earth.https://digitalcommons.imsa.edu/archives_sir/1026/thumbnail.jp

    An integrative workflow to study large-scale biochemical networks

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    I propose an integrative workflow to study large-scale biochemical networks by combining omics data, network structure and dynamical analysis to unravel disease mechanisms. Using the workflow, I identified core regulatory networks from the E2F1 network underlying EMT in bladder and breast cancer and detected disease signatures and drug targets, which were experimentally validated. Further, I developed a hybrid modeling framework that combines ODE- with logical-models to analyze the dynamics of large-scale non-linear systems. This thesis is a contribution to interdisciplinary cancer research

    TARGETING NUCLEAR FACTOR KAPPA B WITH CHELATED ZINC COMPOUNDS TOWARDS ANTICANCER DRUG DESIGN

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    Objective: The objective of the study was to analyse the target-ligand interactions between nuclear factor-κB (NF-κB) and chelated Zinc compounds and to explore the anticancer drug potential of these ligands by a bio computational approach. Methods: Bioinformatics databases and tools were applied for the study. Three dimensional structure of the target NF-κB was retrieved from Protein Data Bank (PDB). The optimized structures of two chelated Zinc compounds, Zinc acetate and Zinc orotate were taken for docking studies with the target using docking tool AutoDock 4.2. Drug properties of the ligands were further assessed by Molinspiration server. Results: Docking results as predicted by AutoDock and as visualized by PyMol viewer were effective for both the ligands. Comparatively, Zinc orotate showed minimum energy and more interactions with the target. Both the ligands satisfied the Lipinski’s rule of five with zero violations. Conclusion: The findings emphasized the promising role of chelated Zinc compounds as potent drug candidates in anti-cancer drug design against NF-κB
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