Coherent storage and manipulation of broadband photons via dynamically controlled Autler-Townes splitting

The coherent control of light with matter, enabling storage and manipulation of optical signals, was revolutionized by electromagnetically induced transparency (EIT), which is a quantum interference effect. For strong electromagnetic fields that induce a wide transparency band, this quantum interference vanishes, giving rise to the well-known phenomenon of Autler-Townes splitting (ATS). To date, it is an open question whether ATS can be directly leveraged for coherent control as more than just a case of "bad" EIT. Here, we establish a protocol showing that dynamically controlled absorption of light in the ATS regime mediates coherent storage and manipulation that is inherently suitable for efficient broadband quantum memory and processing devices. We experimentally demonstrate this protocol by storing and manipulating nanoseconds-long optical pulses through a collective spin state of laser-cooled Rb atoms for up to a microsecond. Furthermore, we show that our approach substantially relaxes the technical requirements intrinsic to established memory schemes, rendering it suitable for broad range of platforms with applications to quantum information processing, high-precision spectroscopy, and metrology.Comment: 14 pages with 6 figures; 3 pages supplementary info with 2 supplementary figure

Coherence of Spin Qubits in Silicon

Given the effectiveness of semiconductor devices for classical computation one is naturally led to consider semiconductor systems for solid state quantum information processing. Semiconductors are particularly suitable where local control of electric fields and charge transport are required. Conventional semiconductor electronics is built upon these capabilities and has demonstrated scaling to large complicated arrays of interconnected devices. However, the requirements for a quantum computer are very different from those for classical computation, and it is not immediately obvious how best to build one in a semiconductor. One possible approach is to use spins as qubits: of nuclei, of electrons, or both in combination. Long qubit coherence times are a prerequisite for quantum computing, and in this paper we will discuss measurements of spin coherence in silicon. The results are encouraging - both electrons bound to donors and the donor nuclei exhibit low decoherence under the right circumstances. Doped silicon thus appears to pass the first test on the road to a quantum computer.Comment: Submitted to J Cond Matter on Nov 15th, 200

FPGA-based DOCSIS upstream demodulation

In recent years, the state-of-the-art in field programmable gate array (FPGA) technology has been advancing rapidly. Consequently, the use of FPGAs is being considered in many applications which have traditionally relied upon application-specific integrated circuits (ASICs). FPGA-based designs have a number of advantages over ASIC-based designs, including lower up-front engineering design costs, shorter time-to-market, and the ability to reconfigure devices in the field. However, ASICs have a major advantage in terms of computational resources. As a result, expensive high performance ASIC algorithms must be redesigned to fit the limited resources available in an FPGA. Concurrently, coaxial cable television and internet networks have been undergoing significant upgrades that have largely been driven by a sharp increase in the use of interactive applications. This has intensified demand for the so-called upstream channels, which allow customers to transmit data into the network. The format and protocol of the upstream channels are defined by a set of standards, known as DOCSIS 3.0, which govern the flow of data through the network. Critical to DOCSIS 3.0 compliance is the upstream demodulator, which is responsible for the physical layer reception from all customers. Although upstream demodulators have typically been implemented as ASICs, the design of an FPGA-based upstream demodulator is an intriguing possibility, as FPGA-based demodulators could potentially be upgraded in the field to support future DOCSIS standards. Furthermore, the lower non-recurring engineering costs associated with FPGA-based designs could provide an opportunity for smaller companies to compete in this market. The upstream demodulator must contain complicated synchronization circuitry to detect, measure, and correct for channel distortions. Unfortunately, many of the synchronization algorithms described in the open literature are not suitable for either upstream cable channels or FPGA implementation. In this thesis, computationally inexpensive and robust synchronization algorithms are explored. In particular, algorithms for frequency recovery and equalization are developed. The many data-aided feedforward frequency offset estimators analyzed in the literature have not considered intersymbol interference (ISI) caused by micro-reflections in the channel. It is shown in this thesis that many prominent frequency offset estimation algorithms become biased in the presence of ISI. A novel high-performance frequency offset estimator which is suitable for implementation in an FPGA is derived from first principles. Additionally, a rule is developed for predicting whether a frequency offset estimator will become biased in the presence of ISI. This rule is used to establish a channel excitation sequence which ensures the proposed frequency offset estimator is unbiased. Adaptive equalizers that compensate for the ISI take a relatively long time to converge, necessitating a lengthy training sequence. The convergence time is reduced using a two step technique to seed the equalizer. First, the ISI equivalent model of the channel is estimated in response to a specific short excitation sequence. Then, the estimated channel response is inverted with a novel algorithm to initialize the equalizer. It is shown that the proposed technique, while inexpensive to implement in an FPGA, can decrease the length of the required equalizer training sequence by up to 70 symbols. It is shown that a preamble segment consisting of repeated 11-symbol Barker sequences which is well-suited to timing recovery can also be used effectively for frequency recovery and channel estimation. By performing these three functions sequentially using a single set of preamble symbols, the overall length of the preamble may be further reduced

Coronary MR angiography at 3T: fat suppression versus water-fat separation

Objectives: To compare Dixon water-fat suppression with spectral pre-saturation with inversion recovery (SPIR) at 3T for coronary magnetic resonance angiography (MRA) and to demonstrate the feasibility of fat suppressed coronary MRA at 3T without administration of a contrast agent. Materials and methods: Coronary MRA with Dixon water-fat separation or with SPIR fat suppression was compared on a 3T scanner equipped with a 32-channel cardiac receiver coil. Eight healthy volunteers were examined. Contrast-to-noise ratio (CNR), signal-to-noise ratio (SNR), right coronary artery (RCA), and left anterior descending (LAD) coronary artery sharpness and length were measured and statistically compared. Two experienced cardiologists graded the visual image quality of reformatted Dixon and SPIR images (1: poor quality to 5: excellent quality). Results: Coronary MRA images in healthy volunteers showed improved contrast with the Dixon technique compared to SPIR (CNR blood-fat: Dixon = 14.9 ± 2.9 and SPIR = 13.9 ± 2.1; p = 0.08, CNR blood-myocardium: Dixon = 10.2 ± 2.7 and SPIR = 9.11 ± 2.6; p = 0.1). The Dixon method led to similar fat suppression (fat SNR with Dixon: 2.1 ± 0.5 vs. SPIR: 2.4 ± 1.2, p = 0.3), but resulted in significantly increased SNR of blood (blood SNR with Dixon: 19.9 ± 4.5 vs. SPIR: 15.5 ± 3.1, p < 0.05). This means the residual fat signal is slightly lower with the Dixon compared to the SIPR technique (although not significant), while the SNR of blood is significantly higher with the Dixon technique. Vessel sharpness of the RCA was similar for Dixon and SPIR (57 ± 7 % vs. 56 ± 9 %, p = 0.2), while the RCA visualized vessel length was increased compared to SPIR fat suppression (107 ± 21 vs. 101 ± 21 mm, p < 0.001). For the LAD, vessel sharpness (50 ± 13 % vs. 50 ± 7 %, p = 0.4) and vessel length (92 ± 46 vs. 90 ± 47 mm, p = 0.4) were similar with both techniques. Consequently, the Dixon technique resulted in an improved visual score of the coronary arteries in the water fat separated images of healthy subjects (RCA: 4.6 ± 0.5 vs. 4.1 ± 0.7, p = 0.01, LAD: 4.1 ± 0.7 vs. 3.5 ± 0.8, p = 0.007). Conclusions: Dixon water-fat separation can significantly improve coronary artery image quality without the use of a contrast agent at 3T

Cardiovascular magnetic resonance artefacts

The multitude of applications offered by CMR make it an increasing popular modality to study the heart and the surrounding vessels. Nevertheless the anatomical complexity of the chest, together with cardiac and respiratory motion, and the fast flowing blood, present many challenges which can possibly translate into imaging artefacts. The literature is wide in terms of papers describing specific MR artefacts in great technical detail. In this review we attempt to summarise, in a language accessible to a clinical readership, some of the most common artefacts found in CMR applications. It begins with an introduction of the most common pulse sequences, and imaging techniques, followed by a brief section on typical cardiovascular applications. This leads to the main section on common CMR artefacts with examples, a short description of the mechanisms behind them, and possible solutions

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma.

Glioblastoma is the most common primary malignant brain tumor in adults and is associated with poor survival. The Ivy Foundation Early Phase Clinical Trials Consortium conducted a randomized, multi-institution clinical trial to evaluate immune responses and survival following neoadjuvant and/or adjuvant therapy with pembrolizumab in 35 patients with recurrent, surgically resectable glioblastoma. Patients who were randomized to receive neoadjuvant pembrolizumab, with continued adjuvant therapy following surgery, had significantly extended overall survival compared to patients that were randomized to receive adjuvant, post-surgical programmed cell death protein 1 (PD-1) blockade alone. Neoadjuvant PD-1 blockade was associated with upregulation of T cell- and interferon-γ-related gene expression, but downregulation of cell-cycle-related gene expression within the tumor, which was not seen in patients that received adjuvant therapy alone. Focal induction of programmed death-ligand 1 in the tumor microenvironment, enhanced clonal expansion of T cells, decreased PD-1 expression on peripheral blood T cells and a decreasing monocytic population was observed more frequently in the neoadjuvant group than in patients treated only in the adjuvant setting. These findings suggest that the neoadjuvant administration of PD-1 blockade enhances both the local and systemic antitumor immune response and may represent a more efficacious approach to the treatment of this uniformly lethal brain tumor