Resolving Structure in Human Brain Organization: Identifying Mesoscale Organization in Weighted Network Representations

Human brain anatomy and function display a combination of modular and hierarchical organization, suggesting the importance of both cohesive structures and variable resolutions in the facilitation of healthy cognitive processes. However, tools to simultaneously probe these features of brain architecture require further development. We propose and apply a set of methods to extract cohesive structures in network representations of brain connectivity using multi-resolution techniques. We employ a combination of soft thresholding, windowed thresholding, and resolution in community detection, that enable us to identify and isolate structures associated with different weights. One such mesoscale structure is bipartivity, which quantifies the extent to which the brain is divided into two partitions with high connectivity between partitions and low connectivity within partitions. A second, complementary mesoscale structure is modularity, which quantifies the extent to which the brain is divided into multiple communities with strong connectivity within each community and weak connectivity between communities. Our methods lead to multi-resolution curves of these network diagnostics over a range of spatial, geometric, and structural scales. For statistical comparison, we contrast our results with those obtained for several benchmark null models. Our work demonstrates that multi-resolution diagnostic curves capture complex organizational profiles in weighted graphs. We apply these methods to the identification of resolution-specific characteristics of healthy weighted graph architecture and altered connectivity profiles in psychiatric disease.Comment: Comments welcom

Benchmarking Distributed Stream Data Processing Systems

The need for scalable and efficient stream analysis has led to the development of many open-source streaming data processing systems (SDPSs) with highly diverging capabilities and performance characteristics. While first initiatives try to compare the systems for simple workloads, there is a clear gap of detailed analyses of the systems' performance characteristics. In this paper, we propose a framework for benchmarking distributed stream processing engines. We use our suite to evaluate the performance of three widely used SDPSs in detail, namely Apache Storm, Apache Spark, and Apache Flink. Our evaluation focuses in particular on measuring the throughput and latency of windowed operations, which are the basic type of operations in stream analytics. For this benchmark, we design workloads based on real-life, industrial use-cases inspired by the online gaming industry. The contribution of our work is threefold. First, we give a definition of latency and throughput for stateful operators. Second, we carefully separate the system under test and driver, in order to correctly represent the open world model of typical stream processing deployments and can, therefore, measure system performance under realistic conditions. Third, we build the first benchmarking framework to define and test the sustainable performance of streaming systems. Our detailed evaluation highlights the individual characteristics and use-cases of each system.Comment: Published at ICDE 201

Open/Closed String Topology and Moduli Space Actions via Open/Closed Hochschild Actions

In this paper we extend our correlation functions to the open/closed case. This gives rise to actions of an open/closed version of the Sullivan PROP as well as an action of the relevant moduli space. There are several unexpected structures and conditions that arise in this extension which are forced upon us by considering the open sector. For string topology type operations, one cannot just consider graphs, but has to take punctures into account and one has to restrict the underlying Frobenius algebras. In the moduli space, one first has to pass to a smaller moduli space which is closed under open/closed duality and then consider covers in order to account for the punctures

Open/closed string topology and moduli space actions via open/closed Hochschild actions

In this paper we extend our correlation functions to the open/closed case. This gives rise to actions of an open/closed version of the Sullivan PROP as well as an action of the relevant moduli space. There are several unexpected structures and conditions that arise in this extension which are forced upon us by considering the open sector. For string topology type operations, one cannot just consider graphs, but has to take punctures into account and one has to restrict the underlying Frobenius algebras. In the moduli space, one first has to pass to a smaller moduli space which is closed under open/closed duality and then consider covers in order to account for the punctures

Benchmark model to assess community structure in evolving networks

Detecting the time evolution of the community structure of networks is crucial to identify major changes in the internal organization of many complex systems, which may undergo important endogenous or exogenous events. This analysis can be done in two ways: considering each snapshot as an independent community detection problem or taking into account the whole evolution of the network. In the first case, one can apply static methods on the temporal snapshots, which correspond to configurations of the system in short time windows, and match afterwards the communities across layers. Alternatively, one can develop dedicated dynamic procedures, so that multiple snapshots are simultaneously taken into account while detecting communities, which allows us to keep memory of the flow. To check how well a method of any kind could capture the evolution of communities, suitable benchmarks are needed. Here we propose a model for generating simple dynamic benchmark graphs, based on stochastic block models. In them, the time evolution consists of a periodic oscillation of the system's structure between configurations with built-in community structure. We also propose the extension of quality comparison indices to the dynamic scenario.Comment: 11 pages, 7 figures, 3 table

Idealized computational models for auditory receptive fields

This paper presents a theory by which idealized models of auditory receptive fields can be derived in a principled axiomatic manner, from a set of structural properties to enable invariance of receptive field responses under natural sound transformations and ensure internal consistency between spectro-temporal receptive fields at different temporal and spectral scales. For defining a time-frequency transformation of a purely temporal sound signal, it is shown that the framework allows for a new way of deriving the Gabor and Gammatone filters as well as a novel family of generalized Gammatone filters, with additional degrees of freedom to obtain different trade-offs between the spectral selectivity and the temporal delay of time-causal temporal window functions. When applied to the definition of a second-layer of receptive fields from a spectrogram, it is shown that the framework leads to two canonical families of spectro-temporal receptive fields, in terms of spectro-temporal derivatives of either spectro-temporal Gaussian kernels for non-causal time or the combination of a time-causal generalized Gammatone filter over the temporal domain and a Gaussian filter over the logspectral domain. For each filter family, the spectro-temporal receptive fields can be either separable over the time-frequency domain or be adapted to local glissando transformations that represent variations in logarithmic frequencies over time. Within each domain of either non-causal or time-causal time, these receptive field families are derived by uniqueness from the assumptions. It is demonstrated how the presented framework allows for computation of basic auditory features for audio processing and that it leads to predictions about auditory receptive fields with good qualitative similarity to biological receptive fields measured in the inferior colliculus (ICC) and primary auditory cortex (A1) of mammals.Comment: 55 pages, 22 figures, 3 table