Laser Based Mid-Infrared Spectroscopic Imaging – Exploring a Novel Method for Application in Cancer Diagnosis

A number of biomedical studies have shown that mid-infrared spectroscopic images can provide both morphological and biochemical information that can be used for the diagnosis of cancer. Whilst this technique has shown great potential it has yet to be employed by the medical profession. By replacing the conventional broadband thermal source employed in modern FTIR spectrometers with high-brightness, broadly tuneable laser based sources (QCLs and OPGs) we aim to solve one of the main obstacles to the transfer of this technology to the medical arena; namely poor signal to noise ratios at high spatial resolutions and short image acquisition times. In this thesis we take the first steps towards developing the optimum experimental configuration, the data processing algorithms and the spectroscopic image contrast and enhancement methods needed to utilise these high intensity laser based sources. We show that a QCL system is better suited to providing numerical absorbance values (biochemical information) than an OPG system primarily due to the QCL pulse stability. We also discuss practical protocols for the application of spectroscopic imaging to cancer diagnosis and present our spectroscopic imaging results from our laser based spectroscopic imaging experiments of oesophageal cancer tissue

Performance analysis and application development of hybrid WiMAX-WiFi IP video surveillance systems

Traditional Closed Circuit Television (CCTV) analogue cameras installed in buildings and other areas of security interest necessitates the use of cable lines. However, analogue systems are limited by distance; and storing analogue data requires huge space or bandwidth. Wired systems are also prone to vandalism, they cannot be installed in a hostile terrain and in heritage sites, where cabling would distort original design. Currently, there is a paradigm shift towards wireless solutions (WiMAX, Wi-Fi, 3G, 4G) to complement and in some cases replace the wired system. A wireless solution of the Fourth-Generation Surveillance System (4GSS) has been proposed in this thesis. It is a hybrid WiMAX-WiFi video surveillance system. The performance analysis of the hybrid WiMAX-WiFi is compared with the conventional WiMAX surveillance models. The video surveillance models and the algorithm that exploit the advantages of both WiMAX and Wi-Fi for scenarios of fixed and mobile wireless cameras have been proposed, simulated and compared with the mathematical/analytical models. The hybrid WiMAX-WiFi video surveillance model has been extended to include a Wireless Mesh configuration on the Wi-Fi part, to improve the scalability and reliability. A performance analysis for hybrid WiMAX-WiFi system with an appropriate Mobility model has been considered for the case of mobile cameras. A security software application for mobile smartphones that sends surveillance images to either local or remote servers has been developed. The developed software has been tested, evaluated and deployed in low bandwidth Wi-Fi wireless network environments. WiMAX is a wireless metropolitan access network technology that provides broadband services to the connected customers. Major modules and units of WiMAX include the Customer Provided Equipment (CPE), the Access Service Network (ASN) which consist one or more Base Stations (BS) and the Connectivity Service Network (CSN). Various interfaces exist between each unit and module. WiMAX is based on the IEEE 802.16 family of standards. Wi-Fi, on the other hand, is a wireless access network operating in the local area network; and it is based on the IEEE 802.11 standards

MediaSync: Handbook on Multimedia Synchronization

This book provides an approachable overview of the most recent advances in the fascinating field of media synchronization (mediasync), gathering contributions from the most representative and influential experts. Understanding the challenges of this field in the current multi-sensory, multi-device, and multi-protocol world is not an easy task. The book revisits the foundations of mediasync, including theoretical frameworks and models, highlights ongoing research efforts, like hybrid broadband broadcast (HBB) delivery and users' perception modeling (i.e., Quality of Experience or QoE), and paves the way for the future (e.g., towards the deployment of multi-sensory and ultra-realistic experiences). Although many advances around mediasync have been devised and deployed, this area of research is getting renewed attention to overcome remaining challenges in the next-generation (heterogeneous and ubiquitous) media ecosystem. Given the significant advances in this research area, its current relevance and the multiple disciplines it involves, the availability of a reference book on mediasync becomes necessary. This book fills the gap in this context. In particular, it addresses key aspects and reviews the most relevant contributions within the mediasync research space, from different perspectives. Mediasync: Handbook on Multimedia Synchronization is the perfect companion for scholars and practitioners that want to acquire strong knowledge about this research area, and also approach the challenges behind ensuring the best mediated experiences, by providing the adequate synchronization between the media elements that constitute these experiences

A framework for Model-Driven Engineering of resilient software-controlled systems

AbstractEmergent paradigms of Industry 4.0 and Industrial Internet of Things expect cyber-physical systems to reliably provide services overcoming disruptions in operative conditions and adapting to changes in architectural and functional requirements. In this paper, we describe a hardware/software framework supporting operation and maintenance of software-controlled systems enhancing resilience by promoting a Model-Driven Engineering (MDE) process to automatically derive structural configurations and failure models from reliability artifacts. Specifically, a reflective architecture developed around digital twins enables representation and control of system Configuration Items properly derived from SysML Block Definition Diagrams, providing support for variation. Besides, a plurality of distributed analytic agents for qualitative evaluation over executable failure models empowers the system with runtime self-assessment and dynamic adaptation capabilities. We describe the framework architecture outlining roles and responsibilities in a System of Systems perspective, providing salient design traits about digital twins and data analytic agents for failure propagation modeling and analysis. We discuss a prototype implementation following the MDE approach, highlighting self-recovery and self-adaptation properties on a real cyber-physical system for vehicle access control to Limited Traffic Zones