Design and test of readout electronics for medical and astrophysics applications

The applied particle physics has a strong R&D tradition aimed at rising the instrumentation performances to achieve relevant results for the scientific community. The know-how achieved in developing particle detectors can be applied to apparently divergent fields like hadrontherapy and cosmic ray detection. A proof of this fact is presented in this doctoral thesis, where the results coming from three different projects are discussed in likewise macro-chapters. A brief introduction (Chapter 1) reports the basic features characterizing a typical particle detector system. This section is developed following the data transmission path: from the sensor, the data moves through the front-end electronics for being readout and collected, ready for the data manipulation. After this general section, the thesis describes the results achieved in two projects developed by the collaboration between the medical physics group of the University of Turin and the Turin section of the Italian Nuclear Institute for Nuclear Physics. Chapter 2 focuses on the TERA09 project. TERA09 is a 64 channels customized chip that has been realized to equip the front-end readout electronics for the new generation of beam monitor chambers for particle therapy applications. In this field, the trend in the accelerators development is moving toward compact solutions providing high-intensity pulsed-beams. However, such a high intensity will saturate the present readout electronics. In order to overcome this critical issue, the TERA09 chip is able to cope with the expected maximum intensity while keeping high resolution by working on a wide conversion-linearity zone which extends from hundreds of pA to hundreds of μA. The chip gain spread is in the order of 1-3% (r.m.s.), with a 200 fC charge resolution. The thesis author took part in the chip design and fully characterized the device. The same group is currently working on behalf of the MoVeIT collaboration for the development of a new silicon strip detector prototype for particle therapy applications. Chapter 3 presents the technical aspects of this project, focusing on the author’s contribution: the front-end electronics design. The sensor adopted for the MoVeIT project is based on 50 μm thin sensors with internal gain, aiming to detect the single beam particle thus counting their number up to 109 cm2/s fluxes, with a pileup probability < 1%. A similar approach would lead to a drastic step forward if compared to the classical and widely used monitoring system based on gas ionization chambers. For what concerns the front-end electronics, the group strategy has been to design two prototypes of custom front-end: one based on a transimpedance preamplifier with a resistive feedback and the other one based on a charge sensitive amplifier. The challenging tasks for the electronics are represented by the charge and dynamic range which are respectively the 3 - 150 fC and the hundreds of MHz instantaneous rate (100 MHz as the milestone, up to 250 MHz ideally). Chapter 4 is a report on the trigger logic development for the Mini-EUSO detector. Mini-EUSO is a telescope designed by the JEM-EUSO Collaboration to map the Earth in the UV range from the vantage point of the International Space Station (ISS), in low Earth orbit. This approach will lay the groundwork for the detection of Extreme Energy Cosmic Rays (EECRs) from space. Due to its 2.5 μs time resolution, Mini-EUSO is capable of detecting a wide range of UV phenomena in the Earth’s atmosphere. In order to maximize the scientific return of the mission, it is necessary to implement a multi-level trigger logic for data selection over different timescales. This logic is key to the success of the mission and thus must be thoroughly tested and carefully integrated into the data processing system prior to the launch. The author took part in the trigger integration in hardware, laboratory trigger tests and also developed the firmware of the trigger ancillary blocks. Chapter 5 closes this doctoral thesis, with a dedicated summary part for each of the three macro-chapters

Neutralisation of myoelectric interference from recorded nerve signals using models of the electrode impedance

Any form of paralysis due to spinal cord injury or other medical condition, can have a significant impact on the quality and life expectancy of an individual. Advances in medicine and surgery have offered solutions that can improve the condition of a patient, however, most of the times an individual’s life does not dramatically improve. Implanted neuroprosthetic devices can partially restore the lost functionalities by means of functional electrical stimulation techniques. This involves applying patterns of electrical current pulses to innervate the neural pathways between the brain and the affected muscles/organs, while recording of neural information from peripheral nerves can be used as feedback to improve performance. Recording naturally occurring nerve signals via implanted electrodes attached to tripolar amplifier configurations is an approach that has been successfully used for obtaining desired information in non-acute preparations since the mid-70s. The neural signal (i.e. ENG), which can be exploited as feedback to another system (e.g. a stimulator), or simply extracted for further processing, is then intrinsically more reliable in comparison to signals obtained by artificial sensors. Sadly, neural recording of this type can be greatly compromised by myoelectric (i.e. EMG) interference, which is present at the neural interface and registered by the recording amplifier. Although current amplifier configurations reduce myoelectric interference this is suboptimal and therefore there is room for improvement. The main difficulty exists in the frequency-dependence of the electrode-tissue interface impedance which is complex. The simplistic Quasi-Tripole amplifier configuration does not allow for the complete removal of interference but it is the most power efficient because it uses only one instrumentation amplifier. Conversely, the True-Tripole and its developed automatic counterpart the Adaptive-Tripole, although minimise interference and provide means of compensating for the electrode asymmetries and changes that occur to the neural interface (e.g. due to tissue growth), they do not remove interference completely as the insignificant electrode impedance is still important. Additionally, removing interference apart from being dependent on the frequency of the interfering source, it is also subject to its proximity and orientation with respect to the recording electrodes, as this affects the field. Hence neutralisation with those two configurations, in reality, is not achieved in the entire bandwidth of the neural signal in the interfering spectrum. As both are less power efficient than the Quasi-Tripole an alternative configuration offering better performance in terms of interference neutralisation (i.e. frequency-independent, insensitive to the external interference fields) and, if possible, consume less power, is considered highly attractive. The motivation of this work is based on the following fact: as there are models that can mimic the frequency response of metal electrodes it should be possible, by constructing a network of an equivalent arrangement to the impedance of electrodes, to fit the characteristic neutralisation impedance – the impedance needed to balance a recording tripole – and ideally require no adjustment for removing interference. The validity of this postulation is proven in a series of in-vitro preparations using a modified version of the Quasi-Tripole made out of discrete circuit components where an impedance is placed at either side of the outer electrodes for balancing the recording arrangement. Various models were used in place of that impedance. In particular, representing the neutralisation impedance as a parallel RC reduced interference by a factor of 10 at all frequencies in the bandwidth of the neural signal while removed it completely at a spot frequency. Conversely, modelling the effect of the constant phase angle impedance of highly polarisable electrodes using a 20 stages non-uniform RC ladder network resulted in the minimisation of interference without the initial requirement of continuous adjustment. It is demonstrated that with a model that does not perfectly fit the impedance profile of a monopolar electrochemical cell an average reduction in interference of about 100 times is achieved, with the cell arranged as a Wheatstone bridge that can be balanced in the ENG band