GPUs outperform current HPC and neuromorphic solutions in terms of speed and energy when simulating a highly-connected cortical model

While neuromorphic systems may be the ultimate platform for deploying spiking neural networks (SNNs), their distributed nature and optimisation for specific types of models makes them unwieldy tools for developing them. Instead, SNN models tend to be developed and simulated on computers or clusters of computers with standard von Neumann CPU architectures. Over the last decade, as well as becoming a common fixture in many workstations, NVIDIA GPU accelerators have entered the High Performance Computing field and are now used in 50% of the Top 10 super computing sites worldwide. In this paper we use our GeNN code generator to re-implement two neo-cortex-inspired, circuit-scale, point neuron network models on GPU hardware. We verify the correctness of our GPU simulations against prior results obtained with NEST running on traditional HPC hardware and compare the performance with respect to speed and energy consumption against published data from CPU-based HPC and neuromorphic hardware. A full-scale model of a cortical column can be simulated at speeds approaching 0.5× real-time using a single NVIDIA Tesla V100 accelerator – faster than is currently possible using a CPU based cluster or the SpiNNaker neuromorphic system. In addition, we find that, across a range of GPU systems, the energy to solution as well as the energy per synaptic event of the microcircuit simulation is as much as 14× lower than either on SpiNNaker or in CPU-based simulations. Besides performance in terms of speed and energy consumption of the simulation, efficient initialisation of models is also a crucial concern, particularly in a research context where repeated runs and parameter-space exploration are required. Therefore, we also introduce in this paper some of the novel parallel initialisation methods implemented in the latest version of GeNN and demonstrate how they can enable further speed and energy advantages

Parallel computing for brain simulation

[Abstract] Background: The human brain is the most complex system in the known universe, it is therefore one of the greatest mysteries. It provides human beings with extraordinary abilities. However, until now it has not been understood yet how and why most of these abilities are produced. Aims: For decades, researchers have been trying to make computers reproduce these abilities, focusing on both understanding the nervous system and, on processing data in a more efficient way than before. Their aim is to make computers process information similarly to the brain. Important technological developments and vast multidisciplinary projects have allowed creating the first simulation with a number of neurons similar to that of a human brain. Conclusion: This paper presents an up-to-date review about the main research projects that are trying to simulate and/or emulate the human brain. They employ different types of computational models using parallel computing: digital models, analog models and hybrid models. This review includes the current applications of these works, as well as future trends. It is focused on various works that look for advanced progress in Neuroscience and still others which seek new discoveries in Computer Science (neuromorphic hardware, machine learning techniques). Their most outstanding characteristics are summarized and the latest advances and future plans are presented. In addition, this review points out the importance of considering not only neurons: Computational models of the brain should also include glial cells, given the proven importance of astrocytes in information processing.Galicia. Consellería de Cultura, Educación e Ordenación Universitaria; GRC2014/049Galicia. Consellería de Cultura, Educación e Ordenación Universitaria; R2014/039Instituto de Salud Carlos III; PI13/0028

Born to learn: The inspiration, progress, and future of evolved plastic artificial neural networks

Biological plastic neural networks are systems of extraordinary computational capabilities shaped by evolution, development, and lifetime learning. The interplay of these elements leads to the emergence of adaptive behavior and intelligence. Inspired by such intricate natural phenomena, Evolved Plastic Artificial Neural Networks (EPANNs) use simulated evolution in-silico to breed plastic neural networks with a large variety of dynamics, architectures, and plasticity rules: these artificial systems are composed of inputs, outputs, and plastic components that change in response to experiences in an environment. These systems may autonomously discover novel adaptive algorithms, and lead to hypotheses on the emergence of biological adaptation. EPANNs have seen considerable progress over the last two decades. Current scientific and technological advances in artificial neural networks are now setting the conditions for radically new approaches and results. In particular, the limitations of hand-designed networks could be overcome by more flexible and innovative solutions. This paper brings together a variety of inspiring ideas that define the field of EPANNs. The main methods and results are reviewed. Finally, new opportunities and developments are presented

Embodied bidirectional simulation of a spiking cortico-basal ganglia-cerebellar-thalamic brain model and a mouse musculoskeletal body model distributed across computers including the supercomputer Fugaku

Embodied simulation with a digital brain model and a realistic musculoskeletal body model provides a means to understand animal behavior and behavioral change. Such simulation can be too large and complex to conduct on a single computer, and so distributed simulation across multiple computers over the Internet is necessary. In this study, we report our joint effort on developing a spiking brain model and a mouse body model, connecting over the Internet, and conducting bidirectional simulation while synchronizing them. Specifically, the brain model consisted of multiple regions including secondary motor cortex, primary motor and somatosensory cortices, basal ganglia, cerebellum and thalamus, whereas the mouse body model, provided by the Neurorobotics Platform of the Human Brain Project, had a movable forelimb with three joints and six antagonistic muscles to act in a virtual environment. Those were simulated in a distributed manner across multiple computers including the supercomputer Fugaku, which is the flagship supercomputer in Japan, while communicating via Robot Operating System (ROS). To incorporate models written in C/C++ in the distributed simulation, we developed a C++ version of the rosbridge library from scratch, which has been released under an open source license. These results provide necessary tools for distributed embodied simulation, and demonstrate its possibility and usefulness toward understanding animal behavior and behavioral change

Neurite, a finite difference large scale parallel program for the simulation of the electrical signal propagation in neurites under mechanical loading

With the growing body of research on traumatic brain injury and spinal cord injury, computational neuroscience has recently focused its modeling efforts on neuronal functional deficits following mechanical loading. However, in most of these efforts, cell damage is generally only characterized by purely mechanistic criteria, function of quantities such as stress, strain or their corresponding rates. The modeling of functional deficits in neurites as a consequence of macroscopic mechanical insults has been rarely explored. In particular, a quantitative mechanically based model of electrophysiological impairment in neuronal cells has only very recently been proposed (Jerusalem et al., 2013). In this paper, we present the implementation details of Neurite: the finite difference parallel program used in this reference. Following the application of a macroscopic strain at a given strain rate produced by a mechanical insult, Neurite is able to simulate the resulting neuronal electrical signal propagation, and thus the corresponding functional deficits. The simulation of the coupled mechanical and electrophysiological behaviors requires computational expensive calculations that increase in complexity as the network of the simulated cells grows. The solvers implemented in Neurite-explicit and implicit-were therefore parallelized using graphics processing units in order to reduce the burden of the simulation costs of large scale scenarios. Cable Theory and Hodgkin-Huxley models were implemented to account for the electrophysiological passive and active regions of a neurite, respectively, whereas a coupled mechanical model accounting for the neurite mechanical behavior within its surrounding medium was adopted as a link between lectrophysiology and mechanics (Jerusalem et al., 2013). This paper provides the details of the parallel implementation of Neurite, along with three different application examples: a long myelinated axon, a segmented dendritic tree, and a damaged axon. The capabilities of the program to deal with large scale scenarios, segmented neuronal structures, and functional deficits under mechanical loading are specifically highlighted

PyGeNN: a Python library for GPU-enhanced Neural Networks

More than half of the Top 10 supercomputing sites worldwide use GPU accelerators and they are becoming ubiquitous in workstations and edge computing devices. GeNN is a C++ library for generating efficient spiking neural network simulation code for GPUs. However, until now, the full flexibility of GeNN could only be harnessed by writing model descriptions and simulation code in C++. Here we present PyGeNN, a Python package which exposes all of GeNN's functionality to Python with minimal overhead. This provides an alternative, arguably more user-friendly, way of using GeNN and allows modelers to use GeNN within the growing Python-based machine learning and computational neuroscience ecosystems. In addition, we demonstrate that, in both Python and C++ GeNN simulations, the overheads of recording spiking data can strongly affect runtimes and show how a new spike recording system can reduce these overheads by up to 10×. Using the new recording system, we demonstrate that by using PyGeNN on a modern GPU, we can simulate a full-scale model of a cortical column faster even than real-time neuromorphic systems. Finally, we show that long simulations of a smaller model with complex stimuli and a custom three-factor learning rule defined in PyGeNN can be simulated almost two orders of magnitude faster than real-time