Neuromyelitis optica spectrum disorder in three generations of a Chinese family

© 2019 Neuromyelitis optica spectrum disorder is an inflammatory demyelinating disease that is largely sporadic. Familial disease has been reported in one or two generations, although its basis remains unknown. We report here three subjects meeting diagnostic criteria for NMOSD in one family: a father and son, and the maternal aunt of the father. Anticipation, of 27 years, was apparent in transmission from father to son. Aquaporin-4 antibodies were observed in the aunt but not the father and son, nor in other family members. A putative pathogenic mutation in the NECL2 gene was not found in this pedigree. This first report of NMOSD in three generations of one family underlines the heterogeneity of familial NMOSD

Aspects of Type I Compactifications and Type I-Heterotic Duality

We review the construction of open descendants of the type IIB superstring on the Z-orbifold. It results in a chiral four-dimensional model with gauge group $SO(8) \otimes U(12)$ and three generations of matter in the $(8,12^*)\oplus (1,66)$ representations. As a test of type I - heterotic duality, that reduces to a weak/weak duality in D=4, a heterotic model on the same orbifold is also presented. The massless spectrum reproduces exactly the one found in the type I case apart from additional twisted matter charged with respect to the SO(8) gauge group. The puzzle is solved by noting that at generic points in the moduli space these states get masses.Comment: Talk delivered at the V Korean-Italian Meeting on Relativistic Astrophysics, 8 pages, Late

Community Involvement - Families / Generations

Cheryl L. Barber et al.: Building Family Strengths: Establishing Community Linkages to Support Families. Patricia Booher: Impact on Three Generations from Growing up on a Wyoming Homestead. Diana Christensen: Providing Support for the Challenging Task Faced by Grandparents Raising Grandchildren. James P. Marshall: Utah’s Marriage Initiative: Strengthening Marriage in Utah. Harriet Shaklee: A Challenge for Communities - Meeting the Needs of Young Children

A social contract approach to sustainability

This paper asks whether it is possible to derive a concern for future generations (“sustainability”) from an account of the firm as a social contract (SC) among its stakeholders. Two aspects of a leading SC model of the firm limit its usefulness for an analysis of sustainability. First, the stakeholders provide investments to the firm over time. Second, the relationship between contemporaries and future generations is marked by asymmetries of power and knowledge that need to be considered while reconstructing the SC today. I discuss three reformulations of the SC that are all, in principle, capable of introducing within the SC a concern for future generations. The first describes the contractors as heads of families. The second envisages a grand meeting of stakeholders of all generations. The third, which I find most defensible, views the SC as an ahistorical agreement reached behind a thick veil of ignorance. This agreement is based on John Rawls’s norm of reciprocity, whereby the stakeholders adopt today the decision they wish all previous (and future) generations had made regarding the rate of consumption of natural resources and emission of pollutants.info:eu-repo/semantics/publishedVersio

Multispecies Sustainability

The sustainability concept in its current form suffers from reductionism. The common interpretation of ‘meeting the needs of the present without compromising the ability of future generations to meet their own needs’ fails to explicitly recognize their interdependence with needs of current and future non-human generations. Here, we argue that the focus of sustainability on human well-being – a purely utilitarian view of nature as a resource for humanity – limits its conceptual and analytical power, as well as real-world sustainability transformation efforts. We propose a broadened concept of ‘multispecies sustainability’ by acknowledging interdependent needs of multiple species’ current and future generations. We develop the concept in three steps: (1) discussing normative aspects, fundamental principles underlying the con- cept, and potential visual models, (2) showcasing radically diverging futures emerging from a scenario thought experiment based on the axes sustainable-unsustainable and multispecies-anthropocentric, and (3) exploring how multispecies sustainability can be applied to research and policy-making through two case studies (a multispecies stakeholder framework and the Healthy Urban Microbiome Initiative)

Sustainability in Interior Design: Incorporating Economy, Equity, and Ecology into the Built Environment

In today’s culture sustainability has become a buzzword, especially in the design community. In the context of design, sustainability proposes to meet the needs of the current population without taking away from future generations (DiDomenica, 2010). This concept can extend further than the design world, because interior designers greatly impact the world by determining what kinds of buildings are being designed and whether or not they are truly sustainable. Sustainability has three parts that are all interconnected: ecology, economy, and equity. Ecology seeks to protect the environment and preserve it for future generations. Economy seeks to do the same thing as ecology but with consideration to money by managing resources so that the ability to support future generations is not diminished. Equity, the least understood of the triad, aims to give each person the chance to meet all of their basic human needs including finding fulfilling work, meeting personal goals, and seeking different styles of livelihood or living. The purpose is to analyze the degree to which the three part triad of sustainability is addressed by interior designers in a two edition special volume of the Journal of Interior Design on sustainable design, and to propose ways in which interior designers could better address all three of the sustainability factors in design solutions. The method of analysis includes a review of articles in the Journal of Interior Design, Volume 37, numbers 1 and 2 on sustainable design followed by the review of three case studies to better understand how designers address design problems relative to the three factors of sustainability in design practice

Teaching sustainability as a social issue: Learning from three teachers

Many researchers cite living more sustainably as humans' most pressing long- term challenge. Living sustainably can be defined as meeting one's needs without interfering with future generations ability to meet their needs. Engaging students with the social causes and effects of sustainability issues may help to address and create dialogue about our own needs and those of future generations. Unfortunately, no studies examine how teachers deliver this topic as a social issue in their classrooms. Through the research question, "What are the curricular, pedagogical, and assessment strategies of three teachers when they teach the social issues of sustainability education?" this qualitative case study seeks findings useful to the education field. For example, teachers might learn how peers plan, implement, and assess this sort of instruction. Teacher educators could create or update pre- service education sustainability frameworks. Or, researchers might study the findings' impact on existing educational paradigms. Thus, this study advances understanding within education on ways to sustain humanity's prosperity

Office design for the multi-generational knowledge workforce

Purpose – The purpose of this paper is to evaluate the impact the workplace can have on knowledge working for a multi-generational workforce. Design/methodology/approach – A case study analysis is undertaken of Leeds City Council (LCC) workplace in the UK. Findings – The findings from the study show that in the context of LCC there are some key differences between the generations regarding knowledge working preferences for formal/informal meeting spaces. In other aspects, such as knowledge sharing, the generations appear to agree on key aspects such as mentoring and team-based working environments. Practical implications – Corporate real estate managers can use the research findings to assist them in providing a range of workplace settings to enhance multi-generational interaction. Originality/value – This paper fills a gap in current research by evaluating workplace preferences based on generational differences.</p