Numerical methods for coupled reconstruction and registration in digital breast tomosynthesis.

Digital Breast Tomosynthesis (DBT) provides an insight into the fine details of normal fibroglandular tissues and abnormal lesions by reconstructing a pseudo-3D image of the breast. In this respect, DBT overcomes a major limitation of conventional X-ray mam- mography by reducing the confounding effects caused by the superposition of breast tissue. In a breast cancer screening or diagnostic context, a radiologist is interested in detecting change, which might be indicative of malignant disease. To help automate this task image registration is required to establish spatial correspondence between time points. Typically, images, such as MRI or CT, are first reconstructed and then registered. This approach can be effective if reconstructing using a complete set of data. However, for ill-posed, limited-angle problems such as DBT, estimating the deformation is com- plicated by the significant artefacts associated with the reconstruction, leading to severe inaccuracies in the registration. This paper presents a mathematical framework, which couples the two tasks and jointly estimates both image intensities and the parameters of a transformation. Under this framework, we compare an iterative method and a simultaneous method, both of which tackle the problem of comparing DBT data by combining reconstruction of a pair of temporal volumes with their registration. We evaluate our methods using various computational digital phantoms, uncom- pressed breast MR images, and in-vivo DBT simulations. Firstly, we compare both iter- ative and simultaneous methods to the conventional, sequential method using an affine transformation model. We show that jointly estimating image intensities and parametric transformations gives superior results with respect to reconstruction fidelity and regis- tration accuracy. Also, we incorporate a non-rigid B-spline transformation model into our simultaneous method. The results demonstrate a visually plausible recovery of the deformation with preservation of the reconstruction fidelity

D-Branes, Holonomy and M-Theory

We show that M-theory on spaces with irreducible holonomy represent Type IIA backgrounds in which a collection of D6-branes wrap a supersymmetric cycle in a manifold with a holonomy group different from the one appearing in the M-theory description. For example, we show that D6-branes wrapping a supersymmetric four-cycle on a manifold with G_2 holonomy is described in eleven dimensions by M-theory on a space with Spin(7) holonomy. Examples of such Type IIA backgrounds which lift to M-theory on spaces with SU(3), G_2, SU(4) and Spin(7) holonomy are considered. The M-theory geometry can then be used to compute exact quantities of the gauge theory on the corresponding D-brane configuration.Comment: 20 pages, harvmac, typos correcte

Supersymmetric Gauge Theories, Intersecting Branes and Free Fermions

We show that various holomorphic quantities in supersymmetric gauge theories can be conveniently computed by configurations of D4-branes and D6-branes. These D-branes intersect along a Riemann surface that is described by a holomorphic curve in a complex surface. The resulting I-brane carries two-dimensional chiral fermions on its world-volume. This system can be mapped directly to the topological string on a large class of non-compact Calabi-Yau manifolds. Inclusion of the string coupling constant corresponds to turning on a constant B-field on the complex surface, which makes this space non-commutative. Including all string loop corrections the free fermion theory is elegantly formulated in terms of holonomic D-modules that replace the classical holomorphic curve in the quantum case.Comment: 67 pages, 6 figure