2,291 research outputs found
Particle algorithms for optimization on binary spaces
We discuss a unified approach to stochastic optimization of pseudo-Boolean
objective functions based on particle methods, including the cross-entropy
method and simulated annealing as special cases. We point out the need for
auxiliary sampling distributions, that is parametric families on binary spaces,
which are able to reproduce complex dependency structures, and illustrate their
usefulness in our numerical experiments. We provide numerical evidence that
particle-driven optimization algorithms based on parametric families yield
superior results on strongly multi-modal optimization problems while local
search heuristics outperform them on easier problems
Team Theory and Person-by-Person Optimization with Binary Decisions.
In this paper, we extend the notion of person-by-person (pbp) optimization to binary decision spaces. The novelty of our approach is the adaptation to a dynamic team context of notions borrowed from the pseudo-boolean optimization field as completely local-global or unimodal functions and submodularity. We also generalize the concept of pbp optimization to the case where groups of decisions makers make joint decisions sequentially, which we refer to as b optimization. The main contribution is a description of sufficient conditions, verifiable in polynomial time, under which a pbp or an b optimization algorithm converges to the team-optimum. As a second contribution, we present a local and greedy algorithm characterized by approximate decision strategies (i.e., strategies based on a local state vector) that return the same decisions as in the complete information framework (where strategies are based on full state vector). As a last contribution, we also show that there exists a subclass of submodular team problems, recognizable in polynomial time, for which the pbp optimization converges for at least an opportune initialization of the algorithm
Compressed Genotyping
Significant volumes of knowledge have been accumulated in recent years
linking subtle genetic variations to a wide variety of medical disorders from
Cystic Fibrosis to mental retardation. Nevertheless, there are still great
challenges in applying this knowledge routinely in the clinic, largely due to
the relatively tedious and expensive process of DNA sequencing. Since the
genetic polymorphisms that underlie these disorders are relatively rare in the
human population, the presence or absence of a disease-linked polymorphism can
be thought of as a sparse signal. Using methods and ideas from compressed
sensing and group testing, we have developed a cost-effective genotyping
protocol. In particular, we have adapted our scheme to a recently developed
class of high throughput DNA sequencing technologies, and assembled a
mathematical framework that has some important distinctions from 'traditional'
compressed sensing ideas in order to address different biological and technical
constraints.Comment: Submitted to IEEE Transaction on Information Theory - Special Issue
on Molecular Biology and Neuroscienc
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