313 research outputs found
Jacobi multipliers, non-local symmetries and nonlinear oscillators
Constants of motion, Lagrangians and Hamiltonians admitted by a family of
relevant nonlinear oscillators are derived using a geometric formalism. The
theory of the Jacobi last multiplier allows us to find Lagrangian descriptions
and constants of the motion. An application of the jet bundle formulation of
symmetries of differential equations is presented in the second part of the
paper. After a short review of the general formalism, the particular case of
non-local symmetries is studied in detail by making use of an extended
formalism. The theory is related to some results previously obtained by
Krasil'shchi, Vinogradov and coworkers. Finally the existence of non-local
symmetries for such two nonlinear oscillators is proved.Comment: 20 page
Dimension of the solutions space of PDEs
We discuss the dimensional characterization of the solutions space of a
formally integrable system of partial differential equations and provide
certain formulas for calculations of these dimensional quantities.Comment: Contribution to the conference GIFT-200
Compressive sensing Petrov-Galerkin approximation of high-dimensional parametric operator equations
We analyze the convergence of compressive sensing based sampling techniques
for the efficient evaluation of functionals of solutions for a class of
high-dimensional, affine-parametric, linear operator equations which depend on
possibly infinitely many parameters. The proposed algorithms are based on
so-called "non-intrusive" sampling of the high-dimensional parameter space,
reminiscent of Monte-Carlo sampling. In contrast to Monte-Carlo, however, a
functional of the parametric solution is then computed via compressive sensing
methods from samples of functionals of the solution. A key ingredient in our
analysis of independent interest consists in a generalization of recent results
on the approximate sparsity of generalized polynomial chaos representations
(gpc) of the parametric solution families, in terms of the gpc series with
respect to tensorized Chebyshev polynomials. In particular, we establish
sufficient conditions on the parametric inputs to the parametric operator
equation such that the Chebyshev coefficients of the gpc expansion are
contained in certain weighted -spaces for . Based on this we
show that reconstructions of the parametric solutions computed from the sampled
problems converge, with high probability, at the , resp.
convergence rates afforded by best -term approximations of the parametric
solution up to logarithmic factors.Comment: revised version, 27 page
Riemann Invariants and Rank-k Solutions of Hyperbolic Systems
In this paper we employ a "direct method" in order to obtain rank-k solutions
of any hyperbolic system of first order quasilinear differential equations in
many dimensions. We discuss in detail the necessary and sufficient conditions
for existence of these type of solutions written in terms of Riemann
invariants. The most important characteristic of this approach is the
introduction of specific first order side conditions consistent with the
original system of PDEs, leading to a generalization of the Riemann invariant
method of solving multi-dimensional systems of PDEs. We have demonstrated the
usefulness of our approach through several examples of hydrodynamic type
systems; new classes of solutions have been obtained in a closed form.Comment: 30 page
A new framework for extracting coarse-grained models from time series with multiscale structure
In many applications it is desirable to infer coarse-grained models from
observational data. The observed process often corresponds only to a few
selected degrees of freedom of a high-dimensional dynamical system with
multiple time scales. In this work we consider the inference problem of
identifying an appropriate coarse-grained model from a single time series of a
multiscale system. It is known that estimators such as the maximum likelihood
estimator or the quadratic variation of the path estimator can be strongly
biased in this setting. Here we present a novel parametric inference
methodology for problems with linear parameter dependency that does not suffer
from this drawback. Furthermore, we demonstrate through a wide spectrum of
examples that our methodology can be used to derive appropriate coarse-grained
models from time series of partial observations of a multiscale system in an
effective and systematic fashion
Reverse engineering of logic-based differential equation models using a mixed-integer dynamic optimization approach
9 páginas, 6 figuras.-- This is an Open Access article distributed under the terms of the Creative Commons Attribution LicenseMotivation: Systems biology models can be used to test new hypotheses formulated on the basis of previous knowledge or new experimental data, contradictory with a previously existing model. New hypotheses often come in the shape of a set of possible regulatory mechanisms. This search is usually not limited to finding a single regulation link, but rather a combination of links subject to great uncertainty or no information about the kinetic parameters.
Results: In this work, we combine a logic-based formalism, to describe all the possible regulatory structures for a given dynamic model of a pathway, with mixed-integer dynamic optimization (MIDO). This framework aims to simultaneously identify the regulatory structure (represented by binary parameters) and the real-valued parameters that are consistent with the available experimental data, resulting in a logic-based differential equation model. The alternative to this would be to perform real-valued parameter estimation for each possible model structure, which is not tractable for models of the size presented in this work. The performance of the method presented here is illustrated with several case studies: a synthetic pathway problem of signaling regulation, a two-component signal transduction pathway in bacterial homeostasis, and a signaling network in liver cancer cellsD.H., J.R.B. and J.S.R. acknowledge funding from the EU FP7 projects
‘NICHE’ (ITN Grant number 289384) and ‘BioPreDyn’ (KBBE grant number
289434). J.R.B. also acknowledges funding from the Spanish Ministerio de
Economía y Competitividad (and the FEDER) through the project
MultiScales (DPI2011-28112-C04-03).Peer reviewe
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