2,469 research outputs found
An Ontology-Based Artificial Intelligence Model for Medicine Side-Effect Prediction: Taking Traditional Chinese Medicine as An Example
In this work, an ontology-based model for AI-assisted medicine side-effect
(SE) prediction is developed, where three main components, including the drug
model, the treatment model, and the AI-assisted prediction model, of proposed
model are presented. To validate the proposed model, an ANN structure is
established and trained by two hundred and forty-two TCM prescriptions. These
data are gathered and classified from the most famous ancient TCM book and more
than one thousand SE reports, in which two ontology-based attributions, hot and
cold, are introduced to evaluate whether the prescription will cause SE or not.
The results preliminarily reveal that it is a relationship between the
ontology-based attributions and the corresponding predicted indicator that can
be learnt by AI for predicting the SE, which suggests the proposed model has a
potential in AI-assisted SE prediction. However, it should be noted that, the
proposed model highly depends on the sufficient clinic data, and hereby, much
deeper exploration is important for enhancing the accuracy of the prediction
Expression model for multiple relationships in the ontology of traditional Chinese medicine knowledge
AbstractObjectiveTo explore multiple relationships in traditional Chinese medicine (TCM) knowledge by comparing binary and multiple relationships during knowledge organization.MethodsCharacteristics of binary and multiple semantic relationships as well as their associations are described. A method to classify multiple relationships based on the involvement of time is proposed and theoretically validated using examples from the ancient TCM classic Important Formulas Worth a Thousand Gold Pieces. The classification includes parallel multiple relationships, restricted multiple relationships, multiple relationships that involve time, and multiple relationships that involve time restriction. Next, construction of multiple semantic relationships for TCM concepts in each classification using Protégé, an ontology editing tool is described.ResultsProtégé is superior to a binary relationship and less than ideal with multiple relationships during the constitution of concept relationships.ConclusionWhen applied in TCM, the semantic relationships constructed by Protégé are superior than those constructed by correlation and/or attribute relationships, but less ideal than those constructed by the human cognitive process
Knowledge-based Biomedical Data Science 2019
Knowledge-based biomedical data science (KBDS) involves the design and
implementation of computer systems that act as if they knew about biomedicine.
Such systems depend on formally represented knowledge in computer systems,
often in the form of knowledge graphs. Here we survey the progress in the last
year in systems that use formally represented knowledge to address data science
problems in both clinical and biological domains, as well as on approaches for
creating knowledge graphs. Major themes include the relationships between
knowledge graphs and machine learning, the use of natural language processing,
and the expansion of knowledge-based approaches to novel domains, such as
Chinese Traditional Medicine and biodiversity.Comment: Manuscript 43 pages with 3 tables; Supplemental material 43 pages
with 3 table
Conceptual graph-based knowledge representation for supporting reasoning in African traditional medicine
Although African patients use both conventional or modern and traditional healthcare simultaneously, it has been proven that 80% of people rely on African traditional medicine (ATM). ATM includes medical activities stemming from practices, customs and traditions which were integral to the distinctive African cultures. It is based mainly on the oral transfer of knowledge, with the risk of losing critical knowledge. Moreover, practices differ according to the regions and the availability of medicinal plants. Therefore, it is necessary to compile tacit, disseminated and complex knowledge from various Tradi-Practitioners (TP) in order to determine interesting patterns for treating a given disease. Knowledge engineering methods for traditional medicine are useful to model suitably complex information needs, formalize knowledge of domain experts and highlight the effective practices for their integration to conventional medicine. The work described in this paper presents an approach which addresses two issues. First it aims at proposing a formal representation model of ATM knowledge and practices to facilitate their sharing and reusing. Then, it aims at providing a visual reasoning mechanism for selecting best available procedures and medicinal plants to treat diseases. The approach is based on the use of the Delphi method for capturing knowledge from various experts which necessitate reaching a consensus. Conceptual graph formalism is used to model ATM knowledge with visual reasoning capabilities and processes. The nested conceptual graphs are used to visually express the semantic meaning of Computational Tree Logic (CTL) constructs that are useful for formal specification of temporal properties of ATM domain knowledge. Our approach presents the advantage of mitigating knowledge loss with conceptual development assistance to improve the quality of ATM care (medical diagnosis and therapeutics), but also patient safety (drug monitoring)
Sequential Condition Evolved Interaction Knowledge Graph for Traditional Chinese Medicine Recommendation
Traditional Chinese Medicine (TCM) has a rich history of utilizing natural
herbs to treat a diversity of illnesses. In practice, TCM diagnosis and
treatment are highly personalized and organically holistic, requiring
comprehensive consideration of the patient's state and symptoms over time.
However, existing TCM recommendation approaches overlook the changes in patient
status and only explore potential patterns between symptoms and prescriptions.
In this paper, we propose a novel Sequential Condition Evolved Interaction
Knowledge Graph (SCEIKG), a framework that treats the model as a sequential
prescription-making problem by considering the dynamics of the patient's
condition across multiple visits. In addition, we incorporate an interaction
knowledge graph to enhance the accuracy of recommendations by considering the
interactions between different herbs and the patient's condition. Experimental
results on a real-world dataset demonstrate that our approach outperforms
existing TCM recommendation methods, achieving state-of-the-art performance
Clinical Decision Support System for Unani Medicine Practitioners
Like other fields of Traditional Medicines, Unani Medicines have been found
as an effective medical practice for ages. It is still widely used in the
subcontinent, particularly in Pakistan and India. However, Unani Medicines
Practitioners are lacking modern IT applications in their everyday clinical
practices. An Online Clinical Decision Support System may address this
challenge to assist apprentice Unani Medicines practitioners in their
diagnostic processes. The proposed system provides a web-based interface to
enter the patient's symptoms, which are then automatically analyzed by our
system to generate a list of probable diseases. The system allows practitioners
to choose the most likely disease and inform patients about the associated
treatment options remotely. The system consists of three modules: an Online
Clinical Decision Support System, an Artificial Intelligence Inference Engine,
and a comprehensive Unani Medicines Database. The system employs advanced AI
techniques such as Decision Trees, Deep Learning, and Natural Language
Processing. For system development, the project team used a technology stack
that includes React, FastAPI, and MySQL. Data and functionality of the
application is exposed using APIs for integration and extension with similar
domain applications. The novelty of the project is that it addresses the
challenge of diagnosing diseases accurately and efficiently in the context of
Unani Medicines principles. By leveraging the power of technology, the proposed
Clinical Decision Support System has the potential to ease access to healthcare
services and information, reduce cost, boost practitioner and patient
satisfaction, improve speed and accuracy of the diagnostic process, and provide
effective treatments remotely. The application will be useful for Unani
Medicines Practitioners, Patients, Government Drug Regulators, Software
Developers, and Medical Researchers.Comment: 59 pages, 11 figures, Computer Science Bachelor's Thesis on use of
Artificial Intelligence in Clinical Decision Support System for Unani
Medicine
A Model for an Intelligent Support Decision System in Aquaculture
The paper purpose an intelligent software system agents–based to support decision in aquculture and the approach of fish diagnosis with informatics methods, techniques and solutions. A major purpose is to develop new methods and techniques for quick fish diagnosis, treatment and prophyilaxis at infectious and parasite-based known disorders, that may occur at fishes raised in high density in intensive raising systems. But, the goal of this paper is to presents a model of an intelligent agents-based diagnosis method will be developed for a support decision system.support decision system, diagnosis, multi-agent system, fish diseases
Enhancing traditional Chinese medicine diagnostics: Integrating ontological knowledge for multi-label symptom entity classification
In traditional Chinese medicine (TCM), artificial intelligence (AI)-assisted syndrome differentiation and disease diagnoses primarily confront the challenges of accurate symptom identification and classification. This study introduces a multi-label entity extraction model grounded in TCM symptom ontology, specifically designed to address the limitations of existing entity recognition models characterized by limited label spaces and an insufficient integration of domain knowledge. This model synergizes a knowledge graph with the TCM symptom ontology framework to facilitate a standardized symptom classification system and enrich it with domain-specific knowledge. It innovatively merges the conventional bidirectional encoder representations from transformers (BERT) + bidirectional long short-term memory (Bi-LSTM) + conditional random fields (CRF) entity recognition methodology with a multi-label classification strategy, thereby adeptly navigating the intricate label interdependencies in the textual data. Introducing a multi-associative feature fusion module is a significant advancement, thereby enabling the extraction of pivotal entity features while discerning the interrelations among diverse categorical labels. The experimental outcomes affirm the model's superior performance in multi-label symptom extraction and substantially elevates the efficiency and accuracy. This advancement robustly underpins research in TCM syndrome differentiation and disease diagnoses
Telemedicine framework using case-based reasoning with evidences
Telemedicine is the medical practice of information exchanged from one location to another through electronic communications to improve the delivery of health care services. This research article describes a telemedicine framework with knowledge engineering using taxonomic reasoning of ontology modeling and semantic similarity. In addition to being a precious support in the procedure of medical decision-making, this framework can be used to strengthen significant collaborations and traceability that are important for the development of official deployment of telemedicine applications. Adequate mechanisms for information management with traceability of the reasoning process are also essential in the fields of epidemiology and public health. In this paper we enrich the case-based reasoning process by taking into account former evidence-based knowledge. We use the regular four steps approach and implement an additional (iii) step: (i) establish diagnosis, (ii) retrieve treatment, (iii) apply evidence, (iv) adaptation, (v) retain. Each step is performed using tools from knowledge engineering and information processing (natural language processing, ontology, indexation, algorithm, etc.). The case representation is done by the taxonomy component of a medical ontology model. The proposed approach is illustrated with an example from the oncology domain. Medical ontology allows a good and efficient modeling of the patient and his treatment. We are pointing up the role of evidences and specialist's opinions in effectiveness and safety of care
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