Comparison of musculoskeletal networks of the primate forelimb

Anatomical network analysis is a framework for quantitatively characterizing the topological organization of anatomical structures, thus providing a way to compare structural integration and modularity among species. Here we apply this approach to study the macroevolution of the forelimb in primates, a structure whose proportions and functions vary widely within this group. We analyzed musculoskeletal network models in 22 genera, including members of all major extant primate groups and three outgroup taxa, after an extensive literature survey and dissections. The modules of the proximal limb are largely similar among taxa, but those of the distal limb show substantial variation. Some network parameters are similar within phylogenetic groups (e.g., non-primates, strepsirrhines, New World monkeys, and hominoids). Reorganization of the modules in the hominoid hand compared to other primates may relate to functional changes such as coordination of individual digit movements, increased pronation/supination, and knuckle-walking. Surprisingly, humans are one of the few taxa we studied in which the thumb musculoskeletal structures do not form an independent anatomical module. This difference may be caused by the loss in humans of some intrinsic muscles associated with the digits or the acquisition of additional muscles that integrate the thumb more closely with surrounding structures

Musculoskeletal modelling of an ostrich (Struthio camelus) pelvic limb: influence of limb orientation on muscular capacity during locomotion

We developed a three-dimensional, biomechanical computer model of the 36 major pelvic limb muscle groups in an ostrich (Struthio camelus) to investigate muscle function in this, the largest of extant birds and model organism for many studies of locomotor mechanics, body size, anatomy and evolution. Combined with experimental data, we use this model to test two main hypotheses. We first query whether ostriches use limb orientations (joint angles) that optimize the moment-generating capacities of their muscles during walking or running. Next, we test whether ostriches use limb orientations at mid-stance that keep their extensor muscles near maximal, and flexor muscles near minimal, moment arms. Our two hypotheses relate to the control priorities that a large bipedal animal might evolve under biomechanical constraints to achieve more effective static weight support. We find that ostriches do not use limb orientations to optimize the moment-generating capacities or moment arms of their muscles. We infer that dynamic properties of muscles or tendons might be better candidates for locomotor optimization. Regardless, general principles explaining why species choose particular joint orientations during locomotion are lacking, raising the question of whether such general principles exist or if clades evolve different patterns (e.g., weighting of muscle force–length or force–velocity properties in selecting postures). This leaves theoretical studies of muscle moment arms estimated for extinct animals at an impasse until studies of extant taxa answer these questions. Finally, we compare our model’s results against those of two prior studies of ostrich limb muscle moment arms, finding general agreement for many muscles. Some flexor and extensor muscles exhibit self-stabilization patterns (posture-dependent switches between flexor/extensor action) that ostriches may use to coordinate their locomotion. However, some conspicuous areas of disagreement in our results illustrate some cautionary principles. Importantly, tendon-travel empirical measurements of muscle moment arms must be carefully designed to preserve 3D muscle geometry lest their accuracy suffer relative to that of anatomically realistic models. The dearth of accurate experimental measurements of 3D moment arms of muscles in birds leaves uncertainty regarding the relative accuracy of different modelling or experimental datasets such as in ostriches. Our model, however, provides a comprehensive set of 3D estimates of muscle actions in ostriches for the first time, emphasizing that avian limb mechanics are highly three-dimensional and complex, and how no muscles act purely in the sagittal plane. A comparative synthesis of experiments and models such as ours could provide powerful synthesis into how anatomy, mechanics and control interact during locomotion and how these interactions evolve. Such a framework could remove obstacles impeding the analysis of muscle function in extinct taxa

Computationally efficient modeling of proprioceptive signals in the upper limb for prostheses: a simulation study.

Accurate models of proprioceptive neural patterns could one day play an important role in the creation of an intuitive proprioceptive neural prosthesis for amputees. This paper looks at combining efficient implementations of biomechanical and proprioceptor models in order to generate signals that mimic human muscular proprioceptive patterns for future experimental work in prosthesis feedback. A neuro-musculoskeletal model of the upper limb with 7 degrees of freedom and 17 muscles is presented and generates real time estimates of muscle spindle and Golgi Tendon Organ neural firing patterns. Unlike previous neuro-musculoskeletal models, muscle activation and excitation levels are unknowns in this application and an inverse dynamics tool (static optimisation) is integrated to estimate these variables. A proprioceptive prosthesis will need to be portable and this is incompatible with the computationally demanding nature of standard biomechanical and proprioceptor modelling. This paper uses and proposes a number of approximations and optimisations to make real time operation on portable hardware feasible. Finally technical obstacles to mimicking natural feedback for an intuitive proprioceptive prosthesis, as well as issues and limitations with existing models, are identified and discussed

Real-time simulation of three-dimensional shoulder girdle and arm dynamics

Electrical stimulation is a promising technology for the restoration of arm function in paralyzed individuals. Control of the paralyzed arm under electrical stimulation, however, is a challenging problem that requires advanced controllers and command interfaces for the user. A real-time model describing the complex dynamics of the arm would allow user-in-the-loop type experiments where the command interface and controller could be assessed. Real-time models of the arm previously described have not included the ability to model the independently controlled scapula and clavicle, limiting their utility for clinical applications of this nature. The goal of this study therefore was to evaluate the performance and mechanical behavior of a real-time, dynamic model of the arm and shoulder girdle. The model comprises seven segments linked by eleven degrees of freedom and actuated by 138 muscle elements. Polynomials were generated to describe the muscle lines of action to reduce computation time, and an implicit, first-order Rosenbrock formulation of the equations of motion was used to increase simulation step-size. The model simulated flexion of the arm faster than real time, simulation time being 92% of actual movement time on standard desktop hardware. Modeled maximum isometric torque values agreed well with values from the literature, showing that the model simulates the moment-generating behavior of a real human arm. The speed of the model enables experiments where the user controls the virtual arm and receives visual feedback in real time. The ability to optimize potential solutions in simulation greatly reduces the burden on the user during development

Biomechanics

Biomechanics is a vast discipline within the field of Biomedical Engineering. It explores the underlying mechanics of how biological and physiological systems move. It encompasses important clinical applications to address questions related to medicine using engineering mechanics principles. Biomechanics includes interdisciplinary concepts from engineers, physicians, therapists, biologists, physicists, and mathematicians. Through their collaborative efforts, biomechanics research is ever changing and expanding, explaining new mechanisms and principles for dynamic human systems. Biomechanics is used to describe how the human body moves, walks, and breathes, in addition to how it responds to injury and rehabilitation. Advanced biomechanical modeling methods, such as inverse dynamics, finite element analysis, and musculoskeletal modeling are used to simulate and investigate human situations in regard to movement and injury. Biomechanical technologies are progressing to answer contemporary medical questions. The future of biomechanics is dependent on interdisciplinary research efforts and the education of tomorrow’s scientists

Dynamics simulation of human box delivering task

Thesis (M.S.) University of Alaska Fairbanks, 2018The dynamic optimization of a box delivery motion is a complex task. The key component is to achieve an optimized motion associated with the box weight, delivering speed, and location. This thesis addresses one solution for determining the optimal delivery of a box. The delivering task is divided into five subtasks: lifting, transition step, carrying, transition step, and unloading. Each task is simulated independently with appropriate boundary conditions so that they can be stitched together to render a complete delivering task. Each task is formulated as an optimization problem. The design variables are joint angle profiles. For lifting and carrying task, the objective function is the dynamic effort. The unloading task is a byproduct of the lifting task, but done in reverse, starting with holding the box and ending with it at its final position. In contrast, for transition task, the objective function is the combination of dynamic effort and joint discomfort. The various joint parameters are analyzed consisting of joint torque, joint angles, and ground reactive forces. A viable optimization motion is generated from the simulation results. It is also empirically validated. This research holds significance for professions containing heavy box lifting and delivering tasks and would like to reduce the chance of injury.Chapter 1 Introduction -- Chapter 2 Skeletal Human Modeling -- Chapter 3 Kinematics and Dynamics -- Chapter 4 Lifting Simulation -- Chapter 5 Carrying Simulation -- Chapter 6 Delivering Simulation -- Chapter 7 Conclusion and Future Research -- Reference

Design Assessment of Two-Wheeled Luggage Based on Mechanical Models and a Usability Test

The purpose of this study is to ergonomically assess two-wheeled luggage design based on mechanical models and a usability test. Three mechanical models were developed for the pulling force estimation and important luggage design factor finding. Three pulling conditions with three motion stages were considered in the model. In addition, a set of pre-questionnaires and a set of post-questionnaires were prepared for the investigation of users’ preferences for each design factor. From the mechanical models, the minimum pulling force was found at the tilted angle of 65.56° in static staus, at the tilted angle of 30° in the initial phase, and at the tilted angle of 65.56° in the sustained phase. Based on the optimal tilted angle, several pole lengths were suggested (41.5” for 5%ile female, 45.5” for 5%ile male and 50%ile female groups, 49.5” for 50%ile male, 95%ile female groups, and 52.5” for 95%ile male group). In addition, some important design factors contributory to the minimum pulling force were found through the mechanical models. According to the results of mechanical models, tilted angles of luggage(), the distance between center of mass and the bottom of luggage (b), and weight of luggage (W) significantly affected the pulling force. Two luggage prototypes were developed by considering the important design factors resulted from the mechanical models and a usability test was conducted. For the usability test, two load weights (33 lbs and 50 lbs), six pole lengths (38.5”, 41.5”, 44.5”, 45.5”, 49.5”, and 52.5”), four subject groups (5%ile female, 50%ile female, 50%ile male, and 95%ile male groups), and two luggage size (22”×14”×10” and 30”×21”×11.5”) were considered in experimental design. Subjects answered pre- and post-questionnaires as soon as they conducted the experiment. Test results demonstrated that most upper body parts were affected by load weights, pole length, and subjects’ knuckle heights. In addition, pole lengths between 38.5” and 49.5” were selected from all subject groups. A pole should be adjustable within the range from 38.5” to 49.5” although the mechanical models suggested the pole lengths between 38.5” and 52.5”. Tilted angle should be maintained from 30º to 50º in this range. This result indicated that there is a gap between the theoretical and practical results. In conclusion, load weights, pole lengths, and subjects’ knuckle heights should primarily be considered when luggage is designed. However, additional studies need to get deeper understanding of the gap between mechanical models and usability. In addition, more systematical survey questionnaires should be developed to provide any possible solutions to reduce the gap