A convolutional autoencoder approach for mining features in cellular electron cryo-tomograms and weakly supervised coarse segmentation

Cellular electron cryo-tomography enables the 3D visualization of cellular organization in the near-native state and at submolecular resolution. However, the contents of cellular tomograms are often complex, making it difficult to automatically isolate different in situ cellular components. In this paper, we propose a convolutional autoencoder-based unsupervised approach to provide a coarse grouping of 3D small subvolumes extracted from tomograms. We demonstrate that the autoencoder can be used for efficient and coarse characterization of features of macromolecular complexes and surfaces, such as membranes. In addition, the autoencoder can be used to detect non-cellular features related to sample preparation and data collection, such as carbon edges from the grid and tomogram boundaries. The autoencoder is also able to detect patterns that may indicate spatial interactions between cellular components. Furthermore, we demonstrate that our autoencoder can be used for weakly supervised semantic segmentation of cellular components, requiring a very small amount of manual annotation.Comment: Accepted by Journal of Structural Biolog

Neuro-memristive Circuits for Edge Computing: A review

The volume, veracity, variability, and velocity of data produced from the ever-increasing network of sensors connected to Internet pose challenges for power management, scalability, and sustainability of cloud computing infrastructure. Increasing the data processing capability of edge computing devices at lower power requirements can reduce several overheads for cloud computing solutions. This paper provides the review of neuromorphic CMOS-memristive architectures that can be integrated into edge computing devices. We discuss why the neuromorphic architectures are useful for edge devices and show the advantages, drawbacks and open problems in the field of neuro-memristive circuits for edge computing

A Bio-Inspired Two-Layer Mixed-Signal Flexible Programmable Chip for Early Vision

A bio-inspired model for an analog programmable array processor (APAP), based on studies on the vertebrate retina, has permitted the realization of complex programmable spatio-temporal dynamics in VLSI. This model mimics the way in which images are processed in the visual pathway, what renders a feasible alternative for the implementation of early vision tasks in standard technologies. A prototype chip has been designed and fabricated in 0.5 μm CMOS. It renders a computing power per silicon area and power consumption that is amongst the highest reported for a single chip. The details of the bio-inspired network model, the analog building block design challenges and trade-offs and some functional tests results are presented in this paper.Office of Naval Research (USA) N-000140210884European Commission IST-1999-19007Ministerio de Ciencia y Tecnología TIC1999-082