47,819 research outputs found
A Collection of Challenging Optimization Problems in Science, Engineering and Economics
Function optimization and finding simultaneous solutions of a system of
nonlinear equations (SNE) are two closely related and important optimization
problems. However, unlike in the case of function optimization in which one is
required to find the global minimum and sometimes local minima, a database of
challenging SNEs where one is required to find stationary points (extrama and
saddle points) is not readily available. In this article, we initiate building
such a database of important SNE (which also includes related function
optimization problems), arising from Science, Engineering and Economics. After
providing a short review of the most commonly used mathematical and
computational approaches to find solutions of such systems, we provide a
preliminary list of challenging problems by writing the Mathematical
formulation down, briefly explaning the origin and importance of the problem
and giving a short account on the currently known results, for each of the
problems. We anticipate that this database will not only help benchmarking
novel numerical methods for solving SNEs and function optimization problems but
also will help advancing the corresponding research areas.Comment: Accepted as an invited contribution to the special session on
Evolutionary Computation for Nonlinear Equation Systems at the 2015 IEEE
Congress on Evolutionary Computation (at Sendai International Center, Sendai,
Japan, from 25th to 28th May, 2015.
Self-Evaluation Applied Mathematics 2003-2008 University of Twente
This report contains the self-study for the research assessment of the Department of Applied Mathematics (AM) of the Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS) at the University of Twente (UT). The report provides the information for the Research Assessment Committee for Applied Mathematics, dealing with mathematical sciences at the three universities of technology in the Netherlands. It describes the state of affairs pertaining to the period 1 January 2003 to 31 December 2008
Systems approaches and algorithms for discovery of combinatorial therapies
Effective therapy of complex diseases requires control of highly non-linear
complex networks that remain incompletely characterized. In particular, drug
intervention can be seen as control of signaling in cellular networks.
Identification of control parameters presents an extreme challenge due to the
combinatorial explosion of control possibilities in combination therapy and to
the incomplete knowledge of the systems biology of cells. In this review paper
we describe the main current and proposed approaches to the design of
combinatorial therapies, including the empirical methods used now by clinicians
and alternative approaches suggested recently by several authors. New
approaches for designing combinations arising from systems biology are
described. We discuss in special detail the design of algorithms that identify
optimal control parameters in cellular networks based on a quantitative
characterization of control landscapes, maximizing utilization of incomplete
knowledge of the state and structure of intracellular networks. The use of new
technology for high-throughput measurements is key to these new approaches to
combination therapy and essential for the characterization of control
landscapes and implementation of the algorithms. Combinatorial optimization in
medical therapy is also compared with the combinatorial optimization of
engineering and materials science and similarities and differences are
delineated.Comment: 25 page
Multi-level agent-based modeling with the Influence Reaction principle
This paper deals with the specification and the implementation of multi-level
agent-based models, using a formal model, IRM4MLS (an Influence Reaction Model
for Multi-Level Simulation), based on the Influence Reaction principle.
Proposed examples illustrate forms of top-down control in (multi-level)
multi-agent based-simulations
A Coevolutionary Particle Swarm Algorithm for Bi-Level Variational Inequalities: Applications to Competition in Highway Transportation Networks
A climate of increasing deregulation in traditional highway transportation,
where the private sector has an expanded role in the provision of traditional
transportation services, provides a background for practical policy issues to be investigated.
One of the key issues of interest, and the focus of this chapter, would
be the equilibrium decision variables offered by participants in this market. By assuming
that the private sector participants play a Nash game, the above problem can
be described as a Bi-Level Variational Inequality (BLVI). Our problem differs from
the classical Cournot-Nash game because each and every player’s actions is constrained
by another variational inequality describing the equilibrium route choice of
users on the network. In this chapter, we discuss this BLVI and suggest a heuristic
coevolutionary particle swarm algorithm for its resolution. Our proposed algorithm
is subsequently tested on example problems drawn from the literature. The numerical
experiments suggest that the proposed algorithm is a viable solution method for
this problem
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