3 research outputs found

    Hypoxia silences the neural activities in the early phase of the phrenic neurogram of eupnea in the piglet

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    OBJECTIVE: We investigated phrenic neurogram patterns during eupnea (normal breathing) and severe hypoxia (gasping) during early maturation in the piglet. METHODS: We used continuous wavelet transform and short time Fourier transform methods to examine the similarity of breathing patterns in both time and frequency domains during early maturation. The phrenic neurogram was recorded during eupnea, severe hypoxia, and recovery from severe hypoxia in piglets in three different age groups: 3–6 days, 10–15 days and 29–35 days. RESULTS: During the first week of postnatal age, respiratory patterns of phrenic activity were marked by frequency components between 30 and 300 Hz during both the early (first half) and late (second half) phases of the neurogram signals during eupnea. The results suggest that there is little difference between the respiratory patterns in both time and frequency domains during eupnea compared to gasping for the first week of postnatal age in piglets. After the first week of postnatal age, the duration of the phrenic neurogram burst significantly increases and the patterns during the early phase of the phrenic neurogram are different from those observed for gasping. However, the patterns that mark the late phase of the phrenic neurograms are still the same as those of gasping. CONCLUSION: Our most significant finding is that hypoxia silences the neural activity in the early phase of phrenic neurogram regardless of maturation

    Respiratory Control: Central and Peripheral Mechanisms

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    Understanding of the respiratory control system has been greatly improved by technological and methodological advances. This volume integrates results from many perspectives, brings together diverse approaches to the investigations, and represents important additions to the field of neural control of breathing. Topics include membrane properties of respiratory neurons, in vitro studies of respiratory control, chemical neuroanatomy, central integration of respiratory afferents, modulation of respiratory pattern by peripheral afferents, respiratory chemoreception, development of respiratory control, behavioral control of breathing, and human ventilatory control. Forty-seven experts in the field report research and discuss novel issues facing future investigations in this collection of papers from an international conference of nearly two hundred leading scientists held in October 1990. This research is of vital importance to respiratory physiologists and those in neurosciences and neurobiology who work with integrative sensory and motor systems and is pertinent to both basic and clinical investigations. Respiratory Control is destined to be widely cited because of the strength of the contributors and the dearth of similar works. The four editors are affiliated with the University of Kentucky: Dexter F. Speck is associate professor of physiology and biophysics, Michael S. Dekin is assistant professor of biological sciences, W. Robert Revelette is research scientist of physiology and biophysics, and Donald T. Frazier is professor and chairman of physiology and biophysics. Experts in the field report current research and discuss novel issues facing future investigations. —SciTech Book Newshttps://uknowledge.uky.edu/upk_biology/1002/thumbnail.jp
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