Genetic variants in ALDH1B1 and alcohol dependence risk in a British and Irish population: A bioinformatic and genetic study

Alcohol is metabolized in the liver via the enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). Polymorphisms in the genes encoding these enzymes, which are common in East Asian populations, can alter enzyme kinetics and hence the risk of alcohol dependence and its sequelae. One of the most important genetic variants, in this regards, is the single nucleotide polymorphism (SNP) rs671 in ALDH2, the gene encoding the primary acetaldehyde metabolizing enzyme ALDH2. However, the protective allele of rs671 is absent in most Europeans although ALDH1B1, which shares significant sequence homology with ALDH2, contains several, potentially functional, missense SNPs that do occur in European populations. The aims of this study were: (i) to use bioinformatic techniques to characterize the possible effects of selected variants in ALDH1B1 on protein structure and function; and, (ii) to genotype three missense and one stop-gain, protein-altering, non-synonymous SNPs in 1478 alcohol dependent cases and 1254 controls of matched British and Irish ancestry. No significant allelic associations were observed between the three missense SNPs and alcohol dependence risk. The minor allele frequency of rs142427338 (Gln378Ter) was higher in alcohol dependent cases than in controls (allelic P = 0.19, OR = 2.98, [0.62-14.37]) but as this SNP is very rare the study was likely underpowered to detect an association with alcohol dependence risk. This potential association will needs to be further evaluated in other large, independent European populations

Mathematical modelling of pressure-driven micropolar biological flow due to metachronal wave propulsion of beating cilia

In this paper, we present an analytical study of pressure-driven flow of micropolar non-Newtonian physiological fluids through a channel comprising two parallel oscillating walls. The cilia are arranged at equal intervals and protrude normally from both walls of the infinitely long channel. A metachronal wave is generated due to natural beating of cilia and the direction of wave propagation is parallel to the direction of fluid flow. Appropriate expressions are presented for deformation via longitudinal and transverse velocity components induced by the ciliary beating phenomenon with cilia assumed to follow elliptic trajectories. The conservation equations for mass, longitudinal and transverse (linear) momentum and angular momentum are reduced in accordance with the long wavelength and creeping Stokesian flow approximations and then normalized with appropriate transformations. The resulting non-linear moving boundary value problem is solved analytically for constant micro-inertia density, subject to physically realistic boundary conditions. Closed-form expressions are derived for axial velocity, angular velocity, volumetric flow rate and pressure rise. The transport phenomena are shown to be dictated by several non-Newtonian parameters, including micropolar material parameter and Eringen coupling parameter, and also several geometric parameters, viz eccentricity parameter, wave number and cilia length. The influence of these parameters on streamline profiles (with a view to addressing trapping features via bolus formation and evolution), pressure gradient and other characteristics are evaluated graphically. Both axial and angular velocities are observed to be substantially modified with both micropolar rheological parameters and furthermore are significantly altered with increasing volumetric flow rate. Free pumping is also examined. An inverse relationship between pressure rise and flow rate is computed which is similar to that observed in Newtonian fluids. The study is relevant to hemodynamics in narrow capillaries and also bio-inspired micro-fluidic devices

Experimental Investigation into the Aerodynamic Ground Effect of a Tailless Chevron-shaped UCAV

This experimental study adequately identified the ground effect region of an unmanned combat air vehicle (UCAV). The AFIT 3\u27 x 3\u27 low-speed wind tunnel and a ground plane were used to simulate the forces and moments on a UCAV model in ground effect. The chevron planform used in this study was originally tested for stability and control and the following extends the already existing database to include ground effects. The ground plane was a flat plate mounted with cylindrical legs. To expand the capabilities of the AFIT 3\u27 x 3\u27 low-speed wind tunnel, hot-wire measurements and flow visualization revealed an adequate testing environment for the use of the ground plane. Examination of the flow through the test section indicated a significant difference in test section transducer velocity and the hot-wire measured velocity. This disparity along with the velocity difference due to the ground plane were accounted for as wind tunnel blockage. In addition, the flow visualization revealed the horseshoe vortices that built up on the front two mounted legs of the ground plane. The ground effect region for the chevron UCAV was characterized by an increase in lift, drag, and a decrease in lift-to-drag ratio. These trends were also noted in previous studies of similar aspect ratio and wing sweep

A hybrid approach to simultaneous localization and mapping in indoors environment

This thesis will present SLAM in the current literature to benefit from then it will present the investigation results for a hybrid approach used where different algorithms using laser, sonar, and camera sensors were tested and compared. The contribution of this thesis is the development of a hybrid approach for SLAM that uses different sensors and where different factors are taken into consideration such as dynamic objects, and the development of a scalable grid map model with new sensors models for real time update of the map.The thesis will show the success found, difficulties faced and limitations of the algorithms developed which were simulated and experimentally tested in an indoors environment