Thoracic Disease Identification and Localization with Limited Supervision

Accurate identification and localization of abnormalities from radiology images play an integral part in clinical diagnosis and treatment planning. Building a highly accurate prediction model for these tasks usually requires a large number of images manually annotated with labels and finding sites of abnormalities. In reality, however, such annotated data are expensive to acquire, especially the ones with location annotations. We need methods that can work well with only a small amount of location annotations. To address this challenge, we present a unified approach that simultaneously performs disease identification and localization through the same underlying model for all images. We demonstrate that our approach can effectively leverage both class information as well as limited location annotation, and significantly outperforms the comparative reference baseline in both classification and localization tasks.Comment: Conference on Computer Vision and Pattern Recognition 2018 (CVPR 2018). V1: CVPR submission; V2: +supplementary; V3: CVPR camera-ready; V4: correction, update reference baseline results according to their latest post; V5: minor correction; V6: Identification results using NIH data splits and various image model

Search Tracker: Human-derived object tracking in-the-wild through large-scale search and retrieval

Humans use context and scene knowledge to easily localize moving objects in conditions of complex illumination changes, scene clutter and occlusions. In this paper, we present a method to leverage human knowledge in the form of annotated video libraries in a novel search and retrieval based setting to track objects in unseen video sequences. For every video sequence, a document that represents motion information is generated. Documents of the unseen video are queried against the library at multiple scales to find videos with similar motion characteristics. This provides us with coarse localization of objects in the unseen video. We further adapt these retrieved object locations to the new video using an efficient warping scheme. The proposed method is validated on in-the-wild video surveillance datasets where we outperform state-of-the-art appearance-based trackers. We also introduce a new challenging dataset with complex object appearance changes.Comment: Under review with the IEEE Transactions on Circuits and Systems for Video Technolog

Guided Curriculum Model Adaptation and Uncertainty-Aware Evaluation for Semantic Nighttime Image Segmentation

Most progress in semantic segmentation reports on daytime images taken under favorable illumination conditions. We instead address the problem of semantic segmentation of nighttime images and improve the state-of-the-art, by adapting daytime models to nighttime without using nighttime annotations. Moreover, we design a new evaluation framework to address the substantial uncertainty of semantics in nighttime images. Our central contributions are: 1) a curriculum framework to gradually adapt semantic segmentation models from day to night via labeled synthetic images and unlabeled real images, both for progressively darker times of day, which exploits cross-time-of-day correspondences for the real images to guide the inference of their labels; 2) a novel uncertainty-aware annotation and evaluation framework and metric for semantic segmentation, designed for adverse conditions and including image regions beyond human recognition capability in the evaluation in a principled fashion; 3) the Dark Zurich dataset, which comprises 2416 unlabeled nighttime and 2920 unlabeled twilight images with correspondences to their daytime counterparts plus a set of 151 nighttime images with fine pixel-level annotations created with our protocol, which serves as a first benchmark to perform our novel evaluation. Experiments show that our guided curriculum adaptation significantly outperforms state-of-the-art methods on real nighttime sets both for standard metrics and our uncertainty-aware metric. Furthermore, our uncertainty-aware evaluation reveals that selective invalidation of predictions can lead to better results on data with ambiguous content such as our nighttime benchmark and profit safety-oriented applications which involve invalid inputs.Comment: ICCV 2019 camera-read

Robust Head-Pose Estimation Based on Partially-Latent Mixture of Linear Regressions

Head-pose estimation has many applications, such as social event analysis, human-robot and human-computer interaction, driving assistance, and so forth. Head-pose estimation is challenging because it must cope with changing illumination conditions, variabilities in face orientation and in appearance, partial occlusions of facial landmarks, as well as bounding-box-to-face alignment errors. We propose tu use a mixture of linear regressions with partially-latent output. This regression method learns to map high-dimensional feature vectors (extracted from bounding boxes of faces) onto the joint space of head-pose angles and bounding-box shifts, such that they are robustly predicted in the presence of unobservable phenomena. We describe in detail the mapping method that combines the merits of unsupervised manifold learning techniques and of mixtures of regressions. We validate our method with three publicly available datasets and we thoroughly benchmark four variants of the proposed algorithm with several state-of-the-art head-pose estimation methods.Comment: 12 pages, 5 figures, 3 table

Map-Guided Curriculum Domain Adaptation and Uncertainty-Aware Evaluation for Semantic Nighttime Image Segmentation

We address the problem of semantic nighttime image segmentation and improve the state-of-the-art, by adapting daytime models to nighttime without using nighttime annotations. Moreover, we design a new evaluation framework to address the substantial uncertainty of semantics in nighttime images. Our central contributions are: 1) a curriculum framework to gradually adapt semantic segmentation models from day to night through progressively darker times of day, exploiting cross-time-of-day correspondences between daytime images from a reference map and dark images to guide the label inference in the dark domains; 2) a novel uncertainty-aware annotation and evaluation framework and metric for semantic segmentation, including image regions beyond human recognition capability in the evaluation in a principled fashion; 3) the Dark Zurich dataset, comprising 2416 unlabeled nighttime and 2920 unlabeled twilight images with correspondences to their daytime counterparts plus a set of 201 nighttime images with fine pixel-level annotations created with our protocol, which serves as a first benchmark for our novel evaluation. Experiments show that our map-guided curriculum adaptation significantly outperforms state-of-the-art methods on nighttime sets both for standard metrics and our uncertainty-aware metric. Furthermore, our uncertainty-aware evaluation reveals that selective invalidation of predictions can improve results on data with ambiguous content such as our benchmark and profit safety-oriented applications involving invalid inputs.Comment: IEEE T-PAMI 202

An automated pattern recognition system for the quantification of inflammatory cells in hepatitis-C-infected liver biopsies

This paper presents an automated system for the quantification of inflammatory cells in hepatitis-C-infected liver biopsies. Initially, features are extracted from colour-corrected biopsy images at positions of interest identified by adaptive thresholding and clump decomposition. A sequential floating search method and principal component analysis are used to reduce dimensionality. Manually annotated training images allow supervised training. The performance of Gaussian parametric and mixture models is compared when used to classify regions as either inflammatory or healthy. The system is optimized using a response surface method that maximises the area under the receiver operating characteristic curve. This system is then tested on images previously ranked by a number of observers with varying levels of expertise. These results are compared to the automated system using Spearman rank correlation. Results show that this system can rank 15 test images, with varying degrees of inflammation, in strong agreement with five expert pathologists