4,657 research outputs found

    Indirect Prophecies Concerning the Death of Christ in Narrative

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    In Luke 24, two disciples recognized that Jesus had predicted He would suffer, be betrayed, and handed over to death by crucifixion, and had said He would rise again on the third day. It was now the third day, and Jesus was no longer in the tomb, but they were confused as to what these things meant and how they came to be. Jesus says to them, “‘O foolish ones and slow of heart to believe in all that the prophets have spoken! Ought not the Christ to have suffered these things and to enter into His glory?’ And beginning with Moses and all the Prophets, He expounded to them all the Scriptures the things concerning Himself” (vv. 25-27). Furthermore, He explained that “all things must be fulfilled which were written in the Law of Moses and the Prophets and the Psalms concerning Me” (v 44). This foretelling by the full scope of the Old Testament, was to communicate that suffering, death, and rising were necessary to bring about repentance and remission of sins (v 47). The thesis of this dissertation is that even within the narrative sections of Scripture that are comprised mostly of the Pentateuch and Former prophets, Christ’s suffering, death, and resurrection were foretold. Specifically, they were foretold not just in the few direct prophecies but within the lives of the characters, in the words that were spoken, within actions done, and in events that played out. It further will contend that typology is the best hermeneutical method to be used to determine the type-antitype connections between Christ’s suffering, death, and resurrection to the characters and events in these sections of Scripture. Moreover, these narratives will be filtered through the two clearest direct prophecies concerning the death of Christ, Isaiah 53 and Psalm 22, both of which were written during the time of the Former Prophets. Because Isaiah 53 is considered by several scholars to not have been written during Isaiah’s lifetime but much later, and by some that David was not a historical monarch of the Israelite people, time is spent establishing the chronology of the Bible and the interconnections between Isaiah’s and David’s writings to the Former Prophets and Pentateuch

    Comparative Multiple Case Study into the Teaching of Problem-Solving Competence in Lebanese Middle Schools

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    This multiple case study investigates how problem-solving competence is integrated into teaching practices in private schools in Lebanon. Its purpose is to compare instructional approaches to problem-solving across three different programs: the American (Common Core State Standards and New Generation Science Standards), French (Socle Commun de Connaissances, de Compétences et de Culture), and Lebanese with a focus on middle school (grades 7, 8, and 9). The project was conducted in nine schools equally distributed among three categories based on the programs they offered: category 1 schools offered the Lebanese program, category 2 the French and Lebanese programs, and category 3 the American and Lebanese programs. Each school was treated as a separate case. Structured observation data were collected using observation logs that focused on lesson objectives and specific cognitive problem-solving processes. The two logs were created based on a document review of the requirements for the three programs. Structured observations were followed by semi-structured interviews that were conducted to explore teachers' beliefs and understandings of problem-solving competence. The comparative analysis of within-category structured observations revealed an instruction ranging from teacher-led practices, particularly in category 1 schools, to more student-centered approaches in categories 2 and 3. The cross-category analysis showed a reliance on cognitive processes primarily promoting exploration, understanding, and demonstrating understanding, with less emphasis on planning and executing, monitoring and reflecting, thus uncovering a weakness in addressing these processes. The findings of the post-observation semi-structured interviews disclosed a range of definitions of problem-solving competence prevalent amongst teachers with clear divergences across the three school categories. This research is unique in that it compares problem-solving teaching approaches across three different programs and explores underlying teachers' beliefs and understandings of problem-solving competence in the Lebanese context. It is hoped that this project will inform curriculum developers about future directions and much-anticipated reforms of the Lebanese program and practitioners about areas that need to be addressed to further improve the teaching of problem-solving competence

    ‘Inner qualities versus inequalities’: A case study of student change learning about Aboriginal health using sequential, explanatory mixed methods

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    Racism and lack of self-determination in health care perpetuate injury and injustice to Aboriginal people. To instil cultural safety at individual, organisational, community and systems levels, a key site of action has been health professional education that seeks to elicit reflexivity, cultural humility and a working understanding of Aboriginal health concepts. Studies in Aboriginal community settings show Family Well Being (FWB) empowerment education is effective in supporting personal and collective reflexivity and transformation through empowering life skills development. Implementation of FWB within educational settings shows early signs of effectiveness among students. Yet knowledge of the steps and processes of student change is lacking. This mixed methods explanatory case study sought to measure and understand change in postgraduate students of a leading Australian university learning about Aboriginal health and wellbeing through blended delivery, including through face-to-face immersion in FWB in an urban classroom. Three interrelated studies investigated fidelity and acceptability of the program, measured and analysed growth and empowerment in students, and explained processes of change observed, through thematic analysis of asynchronous online discussions using lenses based on transformative learning and empowerment. Researcher reflexivity was promoted by Aboriginal supervision. Over six years, 194 students enrolled in two different Aboriginal public health courses, 85 of them in the FWB course. As well as achieving program fidelity and acceptability, pre/post-course change in students across a range of emotional empowerment, personal growth and life-long learning processes was measured in the FWB group. Thematic analysis revealed students’ fluid and recursive processes of transformative learning in their professional selves and capacities to act in domains important to Aboriginal health. This case study contributes new knowledge critical to strengthening health professional capabilities for ever more complex, uncertain and emotionally demanding sites of practice, and to work in empowering ways—with, not for, Aboriginal people and communities

    Caracterización molecular con técnicas de secuenciación masiva para el estudio de transmisión y evolución de mycobacterium tuberculosis complex en Aragón

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    En la presente tesis doctoral se ha estudiado la epidemiología molecular de la tuberculosis en Aragón utilizando técnicas de secuenciación masiva. Se presenta como compendio de publicaciones.<br /

    Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs

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    Publisher Copyright: © 2023 European Food Safety Authority. EFSA Journal published by Wiley-VCH GmbH on behalf of European Food Safety Authority.In 2015, EFSA established a temporary tolerable daily intake (t-TDI) for BPA of 4 μg/kg body weight (bw) per day. In 2016, the European Commission mandated EFSA to re-evaluate the risks to public health from the presence of BPA in foodstuffs and to establish a tolerable daily intake (TDI). For this re-evaluation, a pre-established protocol was used that had undergone public consultation. The CEP Panel concluded that it is Unlikely to Very Unlikely that BPA presents a genotoxic hazard through a direct mechanism. Taking into consideration the evidence from animal data and support from human observational studies, the immune system was identified as most sensitive to BPA exposure. An effect on Th17 cells in mice was identified as the critical effect; these cells are pivotal in cellular immune mechanisms and involved in the development of inflammatory conditions, including autoimmunity and lung inflammation. A reference point (RP) of 8.2 ng/kg bw per day, expressed as human equivalent dose, was identified for the critical effect. Uncertainty analysis assessed a probability of 57–73% that the lowest estimated Benchmark Dose (BMD) for other health effects was below the RP based on Th17 cells. In view of this, the CEP Panel judged that an additional uncertainty factor (UF) of 2 was needed for establishing the TDI. Applying an overall UF of 50 to the RP, a TDI of 0.2 ng BPA/kg bw per day was established. Comparison of this TDI with the dietary exposure estimates from the 2015 EFSA opinion showed that both the mean and the 95th percentile dietary exposures in all age groups exceeded the TDI by two to three orders of magnitude. Even considering the uncertainty in the exposure assessment, the exceedance being so large, the CEP Panel concluded that there is a health concern from dietary BPA exposure.Peer reviewe

    Motivational support intervention to reduce smoking and increase physical activity in smokers not ready to quit: the TARS RCT.

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    BACKGROUND: Physical activity can support smoking cessation for smokers wanting to quit, but there have been no studies on supporting smokers wanting only to reduce. More broadly, the effect of motivational support for such smokers is unclear. OBJECTIVES: The objectives were to determine if motivational support to increase physical activity and reduce smoking for smokers not wanting to immediately quit helps reduce smoking and increase abstinence and physical activity, and to determine if this intervention is cost-effective. DESIGN: This was a multicentred, two-arm, parallel-group, randomised (1 : 1) controlled superiority trial with accompanying trial-based and model-based economic evaluations, and a process evaluation. SETTING AND PARTICIPANTS: Participants from health and other community settings in four English cities received either the intervention (n = 457) or usual support (n = 458). INTERVENTION: The intervention consisted of up to eight face-to-face or telephone behavioural support sessions to reduce smoking and increase physical activity. MAIN OUTCOME MEASURES: The main outcome measures were carbon monoxide-verified 6- and 12-month floating prolonged abstinence (primary outcome), self-reported number of cigarettes smoked per day, number of quit attempts and carbon monoxide-verified abstinence at 3 and 9 months. Furthermore, self-reported (3 and 9 months) and accelerometer-recorded (3 months) physical activity data were gathered. Process items, intervention costs and cost-effectiveness were also assessed. RESULTS: The average age of the sample was 49.8 years, and participants were predominantly from areas with socioeconomic deprivation and were moderately heavy smokers. The intervention was delivered with good fidelity. Few participants achieved carbon monoxide-verified 6-month prolonged abstinence [nine (2.0%) in the intervention group and four (0.9%) in the control group; adjusted odds ratio 2.30 (95% confidence interval 0.70 to 7.56)] or 12-month prolonged abstinence [six (1.3%) in the intervention group and one (0.2%) in the control group; adjusted odds ratio 6.33 (95% confidence interval 0.76 to 53.10)]. At 3 months, the intervention participants smoked fewer cigarettes than the control participants (21.1 vs. 26.8 per day). Intervention participants were more likely to reduce cigarettes by ≥ 50% by 3 months [18.9% vs. 10.5%; adjusted odds ratio 1.98 (95% confidence interval 1.35 to 2.90] and 9 months [14.4% vs. 10.0%; adjusted odds ratio 1.52 (95% confidence interval 1.01 to 2.29)], and reported more moderate-to-vigorous physical activity at 3 months [adjusted weekly mean difference of 81.61 minutes (95% confidence interval 28.75 to 134.47 minutes)], but not at 9 months. Increased physical activity did not mediate intervention effects on smoking. The intervention positively influenced most smoking and physical activity beliefs, with some intervention effects mediating changes in smoking and physical activity outcomes. The average intervention cost was estimated to be £239.18 per person, with an overall additional cost of £173.50 (95% confidence interval -£353.82 to £513.77) when considering intervention and health-care costs. The 1.1% absolute between-group difference in carbon monoxide-verified 6-month prolonged abstinence provided a small gain in lifetime quality-adjusted life-years (0.006), and a minimal saving in lifetime health-care costs (net saving £236). CONCLUSIONS: There was no evidence that behavioural support for smoking reduction and increased physical activity led to meaningful increases in prolonged abstinence among smokers with no immediate plans to quit smoking. The intervention is not cost-effective. LIMITATIONS: Prolonged abstinence rates were much lower than expected, meaning that the trial was underpowered to provide confidence that the intervention doubled prolonged abstinence. FUTURE WORK: Further research should explore the effects of the present intervention to support smokers who want to reduce prior to quitting, and/or extend the support available for prolonged reduction and abstinence. TRIAL REGISTRATION: This trial is registered as ISRCTN47776579. FUNDING: This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 27, No. 4. See the NIHR Journals Library website for further project information

    Current Challenges in the Application of Algorithms in Multi-institutional Clinical Settings

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    The Coronavirus disease pandemic has highlighted the importance of artificial intelligence in multi-institutional clinical settings. Particularly in situations where the healthcare system is overloaded, and a lot of data is generated, artificial intelligence has great potential to provide automated solutions and to unlock the untapped potential of acquired data. This includes the areas of care, logistics, and diagnosis. For example, automated decision support applications could tremendously help physicians in their daily clinical routine. Especially in radiology and oncology, the exponential growth of imaging data, triggered by a rising number of patients, leads to a permanent overload of the healthcare system, making the use of artificial intelligence inevitable. However, the efficient and advantageous application of artificial intelligence in multi-institutional clinical settings faces several challenges, such as accountability and regulation hurdles, implementation challenges, and fairness considerations. This work focuses on the implementation challenges, which include the following questions: How to ensure well-curated and standardized data, how do algorithms from other domains perform on multi-institutional medical datasets, and how to train more robust and generalizable models? Also, questions of how to interpret results and whether there exist correlations between the performance of the models and the characteristics of the underlying data are part of the work. Therefore, besides presenting a technical solution for manual data annotation and tagging for medical images, a real-world federated learning implementation for image segmentation is introduced. Experiments on a multi-institutional prostate magnetic resonance imaging dataset showcase that models trained by federated learning can achieve similar performance to training on pooled data. Furthermore, Natural Language Processing algorithms with the tasks of semantic textual similarity, text classification, and text summarization are applied to multi-institutional, structured and free-text, oncology reports. The results show that performance gains are achieved by customizing state-of-the-art algorithms to the peculiarities of the medical datasets, such as the occurrence of medications, numbers, or dates. In addition, performance influences are observed depending on the characteristics of the data, such as lexical complexity. The generated results, human baselines, and retrospective human evaluations demonstrate that artificial intelligence algorithms have great potential for use in clinical settings. However, due to the difficulty of processing domain-specific data, there still exists a performance gap between the algorithms and the medical experts. In the future, it is therefore essential to improve the interoperability and standardization of data, as well as to continue working on algorithms to perform well on medical, possibly, domain-shifted data from multiple clinical centers

    Computer Vision and Architectural History at Eye Level:Mixed Methods for Linking Research in the Humanities and in Information Technology

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    Information on the history of architecture is embedded in our daily surroundings, in vernacular and heritage buildings and in physical objects, photographs and plans. Historians study these tangible and intangible artefacts and the communities that built and used them. Thus valuableinsights are gained into the past and the present as they also provide a foundation for designing the future. Given that our understanding of the past is limited by the inadequate availability of data, the article demonstrates that advanced computer tools can help gain more and well-linked data from the past. Computer vision can make a decisive contribution to the identification of image content in historical photographs. This application is particularly interesting for architectural history, where visual sources play an essential role in understanding the built environment of the past, yet lack of reliable metadata often hinders the use of materials. The automated recognition contributes to making a variety of image sources usable forresearch.<br/

    Workshop Proceedings of the 12th edition of the KONVENS conference

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    The 2014 issue of KONVENS is even more a forum for exchange: its main topic is the interaction between Computational Linguistics and Information Science, and the synergies such interaction, cooperation and integrated views can produce. This topic at the crossroads of different research traditions which deal with natural language as a container of knowledge, and with methods to extract and manage knowledge that is linguistically represented is close to the heart of many researchers at the Institut für Informationswissenschaft und Sprachtechnologie of Universität Hildesheim: it has long been one of the institute’s research topics, and it has received even more attention over the last few years

    Relevance of parental monitoring strategies in explanation of externalising behaviour problems in adolescence: Mediation of parental knowledge

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    A process model of parental monitoring (PM) proposes that PM occurs in two distinct stages: before the adolescent goes out and when they return home. Parental and adolescent responses to monitoring interactions impact on future monitoring episodes. Research suggests that passive PM strategies (e.g. child disclosure) correlate with higher parental knowledge and less behavior problems. Self-reported measures were used on a sample of 507 Belgrade secondary school students (42.1% male) to examine the mediating effect (mediation analysis using JASP) of parental knowledge (the Scale of Parental Monitoring) on the relationship of PM strategies (Child Disclosure, Parental Solicitation and Parental Control) (the Scale of Parental Monitoring) with externalising problems (Aggressive and Rule-Breaking Behaviour) (ASEBA, YSR). The research results show that Parental Knowledge mediate the relation of Child Disclosure and RuleBreaking Behaviour (z = -6.544, p < .001) and Parental Control and Rule-Breaking Behaviour (z =-3.770, p< .001). No direct link between Parental Control and RuleBreaking Behavior, as well as Parental Solicitation and Rule-Breaking Behavior were established. Full mediation of the link between Child Disclosure and Aggressive Behavior by Parental Knowledge is found (total indirect effect z = -4.050, p < .001). The research results were discussed in the context of the relevance of the PM strategies for greater parental knowledge and prevention of externalising problems in adolescence
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