Memes of Gandhi and Mercury in Anti-Vaccination Discourse

This study focuses on two widely circulating memes in the anti-vaccination movement, namely lists of vaccine ingredients containing mercury, and quotes attributed to Mahatma Gandhi. Mercury has been identified by conspiracy theorists as one of the most harmful components of vaccines, and Gandhi, who has condemned vaccination practices, has been celebrated as a significant source of authority. Quotes attributed to Gandhi against vaccination, complete with picture and embellished font, circulate across various popular platforms, as do intimidating images of syringes dipped in poison coupled with a list of seemingly occult or dangerous ingredients. This article analyses both memes, moving from the imageboard 4chan to the search engine Google Images, and illustrates how the repurposed, often ironic use of visual tropes can either undermine or strengthen the claims that accompany them. The aim is to explore the intersections of conspiracy theory, visual rhetoric, and digital communication in order to elucidate the ambiguity of memes as vehicles for the spread of controversial health-related information

Adaptive memory hierarchies for next generation tiled microarchitectures

Les últimes dècades el rendiment dels processadors i de les memòries ha millorat a diferent ritme, limitant el rendiment dels processadors i creant el conegut memory gap. Sol·lucionar aquesta diferència de rendiment és un camp d'investigació d'actualitat i que requereix de noves sol·lucions. Una sol·lució a aquest problema són les memòries “cache”, que permeten reduïr l'impacte d'unes latències de memòria creixents i que conformen la jerarquia de memòria. La majoria de d'organitzacions de les “caches” estan dissenyades per a uniprocessadors o multiprcessadors tradicionals. Avui en dia, però, el creixent nombre de transistors disponible per xip ha permès l'aparició de xips multiprocessador (CMPs). Aquests xips tenen diferents propietats i limitacions i per tant requereixen de jerarquies de memòria específiques per tal de gestionar eficientment els recursos disponibles. En aquesta tesi ens hem centrat en millorar el rendiment i la eficiència energètica de la jerarquia de memòria per CMPs, des de les “caches” fins als controladors de memòria. A la primera part d'aquesta tesi, s'han estudiat organitzacions tradicionals per les “caches” com les privades o compartides i s'ha pogut constatar que, tot i que funcionen bé per a algunes aplicacions, un sistema que s'ajustés dinàmicament seria més eficient. Tècniques com el Cooperative Caching (CC) combinen els avantatges de les dues tècniques però requereixen un mecanisme centralitzat de coherència que té un consum energètic molt elevat. És per això que en aquesta tesi es proposa el Distributed Cooperative Caching (DCC), un mecanisme que proporciona coherència en CMPs i aplica el concepte del cooperative caching de forma distribuïda. Mitjançant l'ús de directoris distribuïts s'obté una sol·lució més escalable i que, a més, disposa d'un mecanisme de marcatge més flexible i eficient energèticament. A la segona part, es demostra que les aplicacions fan diferents usos de la “cache” i que si es realitza una distribució de recursos eficient es poden aprofitar els que estan infrautilitzats. Es proposa l'Elastic Cooperative Caching (ElasticCC), una organització capaç de redistribuïr la memòria “cache” dinàmicament segons els requeriments de cada aplicació. Una de les contribucions més importants d'aquesta tècnica és que la reconfiguració es decideix completament a través del maquinari i que tots els mecanismes utilitzats es basen en estructures distribuïdes, permetent una millor escalabilitat. ElasticCC no només és capaç de reparticionar les “caches” segons els requeriments de cada aplicació, sinó que, a més a més, és capaç d'adaptar-se a les diferents fases d'execució de cada una d'elles. La nostra avaluació també demostra que la reconfiguració dinàmica de l'ElasticCC és tant eficient que gairebé proporciona la mateixa taxa de fallades que una configuració amb el doble de memòria.Finalment, la tesi es centra en l'estudi del comportament de les memòries DRAM i els seus controladors en els CMPs. Es demostra que, tot i que els controladors tradicionals funcionen eficientment per uniprocessadors, en CMPs els diferents patrons d'accés obliguen a repensar com estan dissenyats aquests sistemes. S'han presentat múltiples sol·lucions per CMPs però totes elles es veuen limitades per un compromís entre el rendiment global i l'equitat en l'assignació de recursos. En aquesta tesi es proposen els Thread Row Buffers (TRBs), una zona d'emmagatenament extra a les memòries DRAM que permetria guardar files de dades específiques per a cada aplicació. Aquest mecanisme permet proporcionar un accés equitatiu a la memòria sense perjudicar el seu rendiment global. En resum, en aquesta tesi es presenten noves organitzacions per la jerarquia de memòria dels CMPs centrades en la escalabilitat i adaptativitat als requeriments de les aplicacions. Els resultats presentats demostren que les tècniques proposades proporcionen un millor rendiment i eficiència energètica que les millors tècniques existents fins a l'actualitat.Processor performance and memory performance have improved at different rates during the last decades, limiting processor performance and creating the well known "memory gap". Solving this performance difference is an important research field and new solutions must be proposed in order to have better processors in the future. Several solutions exist, such as caches, that reduce the impact of longer memory accesses and conform the system memory hierarchy. However, most of the existing memory hierarchy organizations were designed for single processors or traditional multiprocessors. Nowadays, the increasing number of available transistors has allowed the apparition of chip multiprocessors, which have different constraints and require new ad-hoc memory systems able to efficiently manage memory resources. Therefore, in this thesis we have focused on improving the performance and energy efficiency of the memory hierarchy of chip multiprocessors, ranging from caches to DRAM memories. In the first part of this thesis we have studied traditional cache organizations such as shared or private caches and we have seen that they behave well only for some applications and that an adaptive system would be desirable. State-of-the-art techniques such as Cooperative Caching (CC) take advantage of the benefits of both worlds. This technique, however, requires the usage of a centralized coherence structure and has a high energy consumption. Therefore we propose the Distributed Cooperative Caching (DCC), a mechanism to provide coherence to chip multiprocessors and apply the concept of cooperative caching in a distributed way. Through the usage of distributed directories we obtain a more scalable solution and, in addition, has a more flexible and energy-efficient tag allocation method. We also show that applications make different uses of cache and that an efficient allocation can take advantage of unused resources. We propose Elastic Cooperative Caching (ElasticCC), an adaptive cache organization able to redistribute cache resources dynamically depending on application requirements. One of the most important contributions of this technique is that adaptivity is fully managed by hardware and that all repartitioning mechanisms are based on distributed structures, allowing a better scalability. ElasticCC not only is able to repartition cache sizes to application requirements, but also is able to dynamically adapt to the different execution phases of each thread. Our experimental evaluation also has shown that the cache partitioning provided by ElasticCC is efficient and is almost able to match the off-chip miss rate of a configuration that doubles the cache space. Finally, we focus in the behavior of DRAM memories and memory controllers in chip multiprocessors. Although traditional memory schedulers work well for uniprocessors, we show that new access patterns advocate for a redesign of some parts of DRAM memories. Several organizations exist for multiprocessor DRAM schedulers, however, all of them must trade-off between memory throughput and fairness. We propose Thread Row Buffers, an extended storage area in DRAM memories able to store a data row for each thread. This mechanism enables a fair memory access scheduling without hurting memory throughput. Overall, in this thesis we present new organizations for the memory hierarchy of chip multiprocessors which focus on the scalability and of the proposed structures and adaptivity to application behavior. Results show that the presented techniques provide a better performance and energy-efficiency than existing state-of-the-art solutions

WRT-1006 Technical Report: Developing the Digital Engineering Competency Framework (DECF) – Phase 2

17 USC 105 interim-entered record; under review.This material is based upon work supported, in whole or in part, by the U.S. Department of Defense through the Office of the Assistant Secretary of Defense for Research and Engineering (ASD(R&E)) under Contract HQ0034-19-D-003 (Task Order 0286).This material is based upon work supported, in whole or in part, by the U.S. Department of Defense through the Office of the Assistant Secretary of Defense for Research and Engineering (ASD(R&E)) under Contract HQ0034-19-D-003 (Task Order 0286). U.S. Government affiliation is unstated in article tex

Architecture aware parallel programming in Glasgow parallel Haskell (GPH)

General purpose computing architectures are evolving quickly to become manycore and hierarchical: i.e. a core can communicate more quickly locally than globally. To be effective on such architectures, programming models must be aware of the communications hierarchy. This thesis investigates a programming model that aims to share the responsibility of task placement, load balance, thread creation, and synchronisation between the application developer and the runtime system. The main contribution of this thesis is the development of four new architectureaware constructs for Glasgow parallel Haskell that exploit information about task size and aim to reduce communication for small tasks, preserve data locality, or to distribute large units of work. We define a semantics for the constructs that specifies the sets of PEs that each construct identifies, and we check four properties of the semantics using QuickCheck. We report a preliminary investigation of architecture aware programming models that abstract over the new constructs. In particular, we propose architecture aware evaluation strategies and skeletons. We investigate three common paradigms, such as data parallelism, divide-and-conquer and nested parallelism, on hierarchical architectures with up to 224 cores. The results show that the architecture-aware programming model consistently delivers better speedup and scalability than existing constructs, together with a dramatic reduction in the execution time variability. We present a comparison of functional multicore technologies and it reports some of the first ever multicore results for the Feedback Directed Implicit Parallelism (FDIP) and the semi-explicit parallelism (GpH and Eden) languages. The comparison reflects the growing maturity of the field by systematically evaluating four parallel Haskell implementations on a common multicore architecture. The comparison contrasts the programming effort each language requires with the parallel performance delivered. We investigate the minimum thread granularity required to achieve satisfactory performance for three implementations parallel functional language on a multicore platform. The results show that GHC-GUM requires a larger thread granularity than Eden and GHC-SMP. The thread granularity rises as the number of cores rises

Run-time management for future MPSoC platforms

In recent years, we are witnessing the dawning of the Multi-Processor Systemon- Chip (MPSoC) era. In essence, this era is triggered by the need to handle more complex applications, while reducing overall cost of embedded (handheld) devices. This cost will mainly be determined by the cost of the hardware platform and the cost of designing applications for that platform. The cost of a hardware platform will partly depend on its production volume. In turn, this means that ??exible, (easily) programmable multi-purpose platforms will exhibit a lower cost. A multi-purpose platform not only requires ??exibility, but should also combine a high performance with a low power consumption. To this end, MPSoC devices integrate computer architectural properties of various computing domains. Just like large-scale parallel and distributed systems, they contain multiple heterogeneous processing elements interconnected by a scalable, network-like structure. This helps in achieving scalable high performance. As in most mobile or portable embedded systems, there is a need for low-power operation and real-time behavior. The cost of designing applications is equally important. Indeed, the actual value of future MPSoC devices is not contained within the embedded multiprocessor IC, but in their capability to provide the user of the device with an amount of services or experiences. So from an application viewpoint, MPSoCs are designed to ef??ciently process multimedia content in applications like video players, video conferencing, 3D gaming, augmented reality, etc. Such applications typically require a lot of processing power and a signi??cant amount of memory. To keep up with ever evolving user needs and with new application standards appearing at a fast pace, MPSoC platforms need to be be easily programmable. Application scalability, i.e. the ability to use just enough platform resources according to the user requirements and with respect to the device capabilities is also an important factor. Hence scalability, ??exibility, real-time behavior, a high performance, a low power consumption and, ??nally, programmability are key components in realizing the success of MPSoC platforms. The run-time manager is logically located between the application layer en the platform layer. It has a crucial role in realizing these MPSoC requirements. As it abstracts the platform hardware, it improves platform programmability. By deciding on resource assignment at run-time and based on the performance requirements of the user, the needs of the application and the capabilities of the platform, it contributes to ??exibility, scalability and to low power operation. As it has an arbiter function between different applications, it enables real-time behavior. This thesis details the key components of such an MPSoC run-time manager and provides a proof-of-concept implementation. These key components include application quality management algorithms linked to MPSoC resource management mechanisms and policies, adapted to the provided MPSoC platform services. First, we describe the role, the responsibilities and the boundary conditions of an MPSoC run-time manager in a generic way. This includes a de??nition of the multiprocessor run-time management design space, a description of the run-time manager design trade-offs and a brief discussion on how these trade-offs affect the key MPSoC requirements. This design space de??nition and the trade-offs are illustrated based on ongoing research and on existing commercial and academic multiprocessor run-time management solutions. Consequently, we introduce a fast and ef??cient resource allocation heuristic that considers FPGA fabric properties such as fragmentation. In addition, this thesis introduces a novel task assignment algorithm for handling soft IP cores denoted as hierarchical con??guration. Hierarchical con??guration managed by the run-time manager enables easier application design and increases the run-time spatial mapping freedom. In turn, this improves the performance of the resource assignment algorithm. Furthermore, we introduce run-time task migration components. We detail a new run-time task migration policy closely coupled to the run-time resource assignment algorithm. In addition to detailing a design-environment supported mechanism that enables moving tasks between an ISP and ??ne-grained recon??gurable hardware, we also propose two novel task migration mechanisms tailored to the Network-on-Chip environment. Finally, we propose a novel mechanism for task migration initiation, based on reusing debug registers in modern embedded microprocessors. We propose a reactive on-chip communication management mechanism. We show that by exploiting an injection rate control mechanism it is possible to provide a communication management system capable of providing a soft (reactive) QoS in a NoC. We introduce a novel, platform independent run-time algorithm to perform quality management, i.e. to select an application quality operating point at run-time based on the user requirements and the available platform resources, as reported by the resource manager. This contribution also proposes a novel way to manage the interaction between the quality manager and the resource manager. In order to have a the realistic, reproducible and ??exible run-time manager testbench with respect to applications with multiple quality levels and implementation tradev offs, we have created an input data generation tool denoted Pareto Surfaces For Free (PSFF). The the PSFF tool is, to the best of our knowledge, the ??rst tool that generates multiple realistic application operating points either based on pro??ling information of a real-life application or based on a designer-controlled random generator. Finally, we provide a proof-of-concept demonstrator that combines these concepts and shows how these mechanisms and policies can operate for real-life situations. In addition, we show that the proposed solutions can be integrated into existing platform operating systems

Mitosis based speculative multithreaded architectures

In the last decade, industry made a right-hand turn and shifted towards multi-core processor designs, also known as Chip-Multi-Processors (CMPs), in order to provide further performance improvements under a reasonable power budget, design complexity, and validation cost. Over the years, several processor vendors have come out with multi-core chips in their product lines and they have become mainstream, with the number of cores increasing in each processor generation. Multi-core processors improve the performance of applications by exploiting Thread Level Parallelism (TLP) while the Instruction Level Parallelism (ILP) exploited by each individual core is limited. These architectures are very efficient when multiple threads are available for execution. However, single-thread sections of code (single-thread applications and serial sections of parallel applications) pose important constraints on the benefits achieved by parallel execution, as pointed out by Amdahl’s law. Parallel programming, even with the help of recently proposed techniques like transactional memory, has proven to be a very challenging task. On the other hand, automatically partitioning applications into threads may be a straightforward task in regular applications, but becomes much harder for irregular programs, where compilers usually fail to discover sufficient TLP. In this scenario, two main directions have been followed in the research community to take benefit of multi-core platforms: Speculative Multithreading (SpMT) and Non-Speculative Clustered architectures. The former splits a sequential application into speculative threads, while the later partitions the instructions among the cores based on data-dependences but avoid large degree of speculation. Despite the large amount of research on both these approaches, the proposed techniques so far have shown marginal performance improvements. In this thesis we propose novel schemes to speed-up sequential or lightly threaded applications in multi-core processors that effectively address the main unresolved challenges of previous approaches. In particular, we propose a SpMT architecture, called Mitosis, that leverages a powerful software value prediction technique to manage inter-thread dependences, based on pre-computation slices (p-slices). Thanks to the accuracy and low cost of this technique, Mitosis is able to effectively parallelize applications even in the presence of frequent dependences among threads. We also propose a novel architecture, called Anaphase, that combines the best of SpMT schemes and clustered architectures. Anaphase effectively exploits ILP, TLP and Memory Level Parallelism (MLP), thanks to its unique finegrain thread decomposition algorithm that adapts to the available parallelism in the application

Mitosis based speculative multithreaded architectures

In the last decade, industry made a right-hand turn and shifted towards multi-core processor designs, also known as Chip-Multi-Processors (CMPs), in order to provide further performance improvements under a reasonable power budget, design complexity, and validation cost. Over the years, several processor vendors have come out with multi-core chips in their product lines and they have become mainstream, with the number of cores increasing in each processor generation. Multi-core processors improve the performance of applications by exploiting Thread Level Parallelism (TLP) while the Instruction Level Parallelism (ILP) exploited by each individual core is limited. These architectures are very efficient when multiple threads are available for execution. However, single-thread sections of code (single-thread applications and serial sections of parallel applications) pose important constraints on the benefits achieved by parallel execution, as pointed out by Amdahl’s law. Parallel programming, even with the help of recently proposed techniques like transactional memory, has proven to be a very challenging task. On the other hand, automatically partitioning applications into threads may be a straightforward task in regular applications, but becomes much harder for irregular programs, where compilers usually fail to discover sufficient TLP. In this scenario, two main directions have been followed in the research community to take benefit of multi-core platforms: Speculative Multithreading (SpMT) and Non-Speculative Clustered architectures. The former splits a sequential application into speculative threads, while the later partitions the instructions among the cores based on data-dependences but avoid large degree of speculation. Despite the large amount of research on both these approaches, the proposed techniques so far have shown marginal performance improvements. In this thesis we propose novel schemes to speed-up sequential or lightly threaded applications in multi-core processors that effectively address the main unresolved challenges of previous approaches. In particular, we propose a SpMT architecture, called Mitosis, that leverages a powerful software value prediction technique to manage inter-thread dependences, based on pre-computation slices (p-slices). Thanks to the accuracy and low cost of this technique, Mitosis is able to effectively parallelize applications even in the presence of frequent dependences among threads. We also propose a novel architecture, called Anaphase, that combines the best of SpMT schemes and clustered architectures. Anaphase effectively exploits ILP, TLP and Memory Level Parallelism (MLP), thanks to its unique finegrain thread decomposition algorithm that adapts to the available parallelism in the application.Postprint (published version

Scientific Advances in STEM

Following a previous topic (Scientific advances in STEM: from professors to students; https://www.mdpi.com/topics/advances_stem), this new topic aims to highlight the importance of establishing collaborations among research groups from different disciplines, combining the scientific knowledge from basic to applied research as well as taking advantage of different research facilities. Fundamental science helps us to understand phenomenological basics, while applied science focuses on products and technology developments, highlighting the need to perform a transference of knowledge to society and the industrial sector

Non-covalent interactions in organotin(IV) derivatives of 5,7-ditertbutyl- and 5,7-diphenyl-1,2,4-triazolo[1,5-a]pyrimidine as recognition motifs in crystalline self- assembly and their in vitro antistaphylococcal activity

Non-covalent interactions are known to play a key role in biological compounds due to their stabilization of the tertiary and quaternary structure of proteins [1]. Ligands similar to purine rings, such as triazolo pyrimidine ones, are very versatile in their interactions with metals and can act as model systems for natural bio-inorganic compounds [2]. A considerable series (twelve novel compounds are reported) of 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine (dbtp) and 5,7-diphenyl- 1,2,4-triazolo[1,5-a]pyrimidine (dptp) were synthesized and investigated by FT-IR and 119Sn M\uf6ssbauer in the solid state and by 1H and 13C NMR spectroscopy, in solution [3]. The X-ray crystal and molecular structures of Et2SnCl2(dbtp)2 and Ph2SnCl2(EtOH)2(dptp)2 were described, in this latter pyrimidine molecules are not directly bound to the metal center but strictly H-bonded, through N(3), to the -OH group of the ethanol moieties. The network of hydrogen bonding and aromatic interactions involving pyrimidine and phenyl rings in both complexes drives their self-assembly. Noncovalent interactions involving aromatic rings are key processes in both chemical and biological recognition, contributing to overall complex stability and forming recognition motifs. It is noteworthy that in Ph2SnCl2(EtOH)2(dptp)2 \u3c0\u2013\u3c0 stacking interactions between pairs of antiparallel triazolopyrimidine rings mimick basepair interactions physiologically occurring in DNA (Fig.1). M\uf6ssbauer spectra suggest for Et2SnCl2(dbtp)2 a distorted octahedral structure, with C-Sn-C bond angles lower than 180\ub0. The estimated angle for Et2SnCl2(dbtp)2 is virtually identical to that determined by X-ray diffraction. Ph2SnCl2(EtOH)2(dptp)2 is characterized by an essentially linear C-Sn-C fragment according to the X-ray all-trans structure. The compounds were screened for their in vitro antibacterial activity on a group of reference staphylococcal strains susceptible or resistant to methicillin and against two reference Gramnegative pathogens [4] . We tested the biological activity of all the specimen against a group of staphylococcal reference strains (S. aureus ATCC 25923, S. aureus ATCC 29213, methicillin resistant S. aureus 43866 and S. epidermidis RP62A) along with Gram-negative pathogens (P. aeruginosa ATCC9027 and E. coli ATCC25922). Ph2SnCl2(EtOH)2(dptp)2 showed good antibacterial activity with a MIC value of 5 \u3bcg mL-1 against S. aureus ATCC29213 and also resulted active against methicillin resistant S. epidermidis RP62A

Towards greater selectivity and peak capacities in multidimensional separations of complex samples

In this thesis, the focus was on understanding recent developments in liquid chromatography (LC) and how these can be applied to improve two-dimensional separations (Chapter 2). The main advances that were of interest for the design of a 3D separation device were those in column technology, instrument capabilities and miniaturized separation devices. We proceeded with an investigation into the miniaturization of comprehensive two-dimensional LC (LC×LC) for the analysis of peptides by direct coupling with a high-resolution mass spectrometer (HR-MS) (Chapter 4). In choosing the best combination of retention mechanisms for the LC×LC system, we have investigated computational programs for the prediction of retention and the optimization of peptide separations in hydrophilic-interaction liquid chromatography (HILIC) and reversed-phase liquid chromatography (RPLC) (Chapter 3). Finally, we investigated the introduction of particles in a 3D-printed device as a model for a future 3D-spatial-separation device (Chapter 5). To reach the ultimate goal of a 3D-spatial-separation device with the capability of achieving a peak capacity of one million, further research is still required. The future outlook following the research in this thesis is described in Chapter 6