436 research outputs found

    Strategies to Improve Antineoplastic Activity of Drugs in Cancer Progression

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    The aim of this Special Issue is to collect reports regarding all the recent strategies, directed at the improvement of antineoplastic activity of drugs in cancer progression, engaging all the expertise needed for the development of new anticancer drugs: medicinal chemistry, pharmacology, molecular biology, and computational and drug delivery studies

    50 Years of quantum chromodynamics – Introduction and Review

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    Review of Particle Physics

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    The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 2,143 new measurements from 709 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons. We summarize searches for hypothetical particles such as supersymmetric particles, heavy bosons, axions, dark photons, etc. Particle properties and search limits are listed in Summary Tables. We give numerous tables, figures, formulae, and reviews of topics such as Higgs Boson Physics, Supersymmetry, Grand Unified Theories, Neutrino Mixing, Dark Energy, Dark Matter, Cosmology, Particle Detectors, Colliders, Probability and Statistics. Among the 120 reviews are many that are new or heavily revised, including a new review on Machine Learning, and one on Spectroscopy of Light Meson Resonances. The Review is divided into two volumes. Volume 1 includes the Summary Tables and 97 review articles. Volume 2 consists of the Particle Listings and contains also 23 reviews that address specific aspects of the data presented in the Listings. The complete Review (both volumes) is published online on the website of the Particle Data Group (pdg.lbl.gov) and in a journal. Volume 1 is available in print as the PDG Book. A Particle Physics Booklet with the Summary Tables and essential tables, figures, and equations from selected review articles is available in print, as a web version optimized for use on phones, and as an Android app.United States Department of Energy (DOE) DE-AC02-05CH11231government of Japan (Ministry of Education, Culture, Sports, Science and Technology)Istituto Nazionale di Fisica Nucleare (INFN)Physical Society of Japan (JPS)European Laboratory for Particle Physics (CERN)United States Department of Energy (DOE

    Advances in Plasma Processes for Polymers

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    Polymerized nanoparticles and nanofibers can be prepared using various processes, such as chemical synthesis, the electrochemical method, electrospinning, ultrasonic irradiation, hard and soft templates, seeding polymerization, interfacial polymerization, and plasma polymerization. Among these processes, plasma polymerization and aerosol-through-plasma (A-T-P) processes have versatile advantages, especially due to them being “dry", for the deposition of plasma polymer films and carbon-based materials with functional properties suitable for a wide range of applications, such as electronic and optical devices, protective coatings, and biomedical materials. Furthermore, it is well known that plasma polymers are highly cross-linked, pinhole free, branched, insoluble, and adhere well to most substrates. In order to synthesize the polymer films using the plasma processes, therefore, it is very important to increase the density and electron temperature of plasma during plasma polymerization

    Side-Channel Analysis and Cryptography Engineering : Getting OpenSSL Closer to Constant-Time

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    As side-channel attacks reached general purpose PCs and started to be more practical for attackers to exploit, OpenSSL adopted in 2005 a flagging mechanism to protect against SCA. The opt-in mechanism allows to flag secret values, such as keys, with the BN_FLG_CONSTTIME flag. Whenever a flag is checked and detected, the library changes its execution flow to SCA-secure functions that are slower but safer, protecting these secret values from being leaked. This mechanism favors performance over security, it is error-prone, and is obscure for most library developers, increasing the potential for side-channel vulnerabilities. This dissertation presents an extensive side-channel analysis of OpenSSL and criticizes its fragile flagging mechanism. This analysis reveals several flaws affecting the library resulting in multiple side-channel attacks, improved cache-timing attack techniques, and a new side channel vector. The first part of this dissertation introduces the main topic and the necessary related work, including the microarchitecture, the cache hierarchy, and attack techniques; then it presents a brief troubled history of side-channel attacks and defenses in OpenSSL, setting the stage for the related publications. This dissertation includes seven original publications contributing to the area of side-channel analysis, microarchitecture timing attacks, and applied cryptography. From an SCA perspective, the results identify several vulnerabilities and flaws enabling protocol-level attacks on RSA, DSA, and ECDSA, in addition to full SCA of the SM2 cryptosystem. With respect to microarchitecture timing attacks, the dissertation presents a new side-channel vector due to port contention in the CPU execution units. And finally, on the applied cryptography front, OpenSSL now enjoys a revamped code base securing several cryptosystems against SCA, favoring a secure-by-default protection against side-channel attacks, instead of the insecure opt-in flagging mechanism provided by the fragile BN_FLG_CONSTTIME flag

    Future Transportation

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    Greenhouse gas (GHG) emissions associated with transportation activities account for approximately 20 percent of all carbon dioxide (co2) emissions globally, making the transportation sector a major contributor to the current global warming. This book focuses on the latest advances in technologies aiming at the sustainable future transportation of people and goods. A reduction in burning fossil fuel and technological transitions are the main approaches toward sustainable future transportation. Particular attention is given to automobile technological transitions, bike sharing systems, supply chain digitalization, and transport performance monitoring and optimization, among others

    The influence of cardiopulmonary bypass on pediatric pharmacokinetics

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