The Profiling Potential of Computer Vision and the Challenge of Computational Empiricism

Computer vision and other biometrics data science applications have commenced a new project of profiling people. Rather than using 'transaction generated information', these systems measure the 'real world' and produce an assessment of the 'world state' - in this case an assessment of some individual trait. Instead of using proxies or scores to evaluate people, they increasingly deploy a logic of revealing the truth about reality and the people within it. While these profiling knowledge claims are sometimes tentative, they increasingly suggest that only through computation can these excesses of reality be captured and understood. This article explores the bases of those claims in the systems of measurement, representation, and classification deployed in computer vision. It asks if there is something new in this type of knowledge claim, sketches an account of a new form of computational empiricism being operationalised, and questions what kind of human subject is being constructed by these technological systems and practices. Finally, the article explores legal mechanisms for contesting the emergence of computational empiricism as the dominant knowledge platform for understanding the world and the people within it

The ethics of uncertainty for data subjects

Modern health data practices come with many practical uncertainties. In this paper, I argue that data subjects’ trust in the institutions and organizations that control their data, and their ability to know their own moral obligations in relation to their data, are undermined by significant uncertainties regarding the what, how, and who of mass data collection and analysis. I conclude by considering how proposals for managing situations of high uncertainty might be applied to this problem. These emphasize increasing organizational flexibility, knowledge, and capacity, and reducing hazard

Generations of interdisciplinarity in bioinformatics

Bioinformatics, a specialism propelled into relevance by the Human Genome Project and the subsequent -omic turn in the life science, is an interdisciplinary field of research. Qualitative work on the disciplinary identities of bioinformaticians has revealed the tensions involved in work in this “borderland.” As part of our ongoing work on the emergence of bioinformatics, between 2010 and 2011, we conducted a survey of United Kingdom-based academic bioinformaticians. Building on insights drawn from our fieldwork over the past decade, we present results from this survey relevant to a discussion of disciplinary generation and stabilization. Not only is there evidence of an attitudinal divide between the different disciplinary cultures that make up bioinformatics, but there are distinctions between the forerunners, founders and the followers; as inter/disciplines mature, they face challenges that are both inter-disciplinary and inter-generational in nature

Exploring the Limitations of Peripheral Blood Transcriptional Biomarkers in Predicting Influenza Vaccine Responsiveness

Systems biology has been recently applied to vaccinology to better understand immunological responses to the influenza vaccine. Particular attention has been paid to the identification of early signatures capable of predicting vaccine immunogenicity. Building fromprevious studies, we employed a recently established algorithm for signature-based clustering of expression profiles, SCUDO, to provide new insights into why blood-derived transcriptome biomarkers often fail to predict the seroresponse to the influenza virus vaccination. Specifically, preexisting immunity against one or more vaccine antigens, which was found to negatively affect the seroresponse, was identified as a confounding factor able to decouple early transcriptome fromlater antibody responses, resulting in the degradation of a biomarker predictive power. Finally, the broadly accepted definition of seroresponse to influenza virus vaccine, represented by the maximum response across the vaccine-targeted strains, was compared to a composite measure integrating the responses against all strains. This analysis revealed that compositemeasures provide amore accurate assessment of the seroresponse to multicomponent influenza vaccines

Paradigmatic Tendencies in Cartography: A Synthesis of the Scientific-Empirical, Critical and Post-Representational Perspectives

Maps have been important elements of visual representation in the development of different societies, and for this reason they have mainly been considered from a practical and utilitarian point of view. This means that cartographers or mapmakers have largely focused on the technical aspects of the cartographic products, and cartography has given little attention to both its theoretical component and to its philosophical and epistemological aspects. The current study is dedicated to consider these views. In this study the main trends, thoughts and different directions in cartography during positivism/empiricism, neo-positivism and post-structuralism are reviewed; and cartography is analysed under the modernism and post-modernism periods. Some of the arguments proposed by philosophers such as Ludwig Wittgenstein and Karl Popper are examined as important contributions in our understanding of the development of cartography and mapping. This study also incorporates the idea or concept of paradigm, which has been taken from the field of the epistemology of sciences. The aforementioned opens a space to analyse cartography in terms of a paradigm shift. In the analysis of each trend within contemporary cartography – from the second half of the twentieth century until today – it is necessary to keep in mind the theoretical scheme of a scientific discipline (object of study, research aims, methods and approaches, and results). This helps to determine the body of knowledge in cartography. It is also important to consider the epistemological context in which the tendencies are developed: positivism/empiricism, realism/structuralism and idealism/hermeneutic. In this way, by considering three epistemological levels - essentialist/ontical (scientific), deconstructive (sociological), and ontological (emergent) - some paradigmatic tendencies are postulated. The first level results in tendencies such as cartographic communication, cartographic semiotics, analytical cartography and cartographic visualisation - all of these belong to the scientific-empirical perspective. In the second level, we have critical cartography, belonging to the critical perspective and that confronts the scientific stances. Finally, in the third level the so-called post-representational cartography arises in open opposition to the traditional representational cartography.Im Entwicklungsprozess verschiedener Gesellschaften sind Karten immer wichtige Elemente visueller Darstellung gewesen. Karten wurden meist aus einer praktischen und utilitaristischen Sicht betrachtet. Das heißt, dass sich Kartographen oder Kartenmacher gezielt auf die technischen Aspekte kartographischer Produkte fokussiert haben, und Kartographie sich nur wenig mit den theoretischen Komponenten und philosophischen oder epistemologischen Aspekten auseinandergesetzt hat. Diese Arbeit verfolgt das Ziel, diese Sichten zu analysieren. Diese Studie untersucht die verschiedenen kartographischen Denkrichtungen, die während des Positivismus/Empirismus, des Neo-Positivismus und der Post-Strukturalismusperioden entstanden sind und analysiert Kartographie der Moderne und post-moderner Perioden. Argumente von Philosophen wie Ludwig Wittgenstein und Karl Popper werden untersucht als wichtige Beiträge zu unserem Verständnis der Entwicklung der Kartographie. Diese Arbeit berücksichtigt auch das Konzept des Paradigmas, welches aus dem Gebiet der wissenschaftlichen Epistemologie adaptiert wurde. Dies eröffnet die Möglichkeit, Kartographie hinsichtlich eines Paradigmenwechsels analysieren zu können. Wenn man die Tendenzen der zeitgenössischen Kartographie – von der zweiten Hälfte des zwanzigsten Jahrhunderts bis heute – studiert, muss der theoretische Rahmen einer wissenschaftlichen Disziplin (Forschungsobjekt, Forschungsziel, Arbeitsmethodik und Ergebnisse) berücksichtigt werden. Dies erlaubt es, das gesammelte Wissen der Kartographie zu ermitteln. Ebenfalls wichtig ist die Berücksichtigung des epistemologischen Kontexts, in dem diese Tendenzen entstanden: Positivismus/Empirismus, Realismus/Strukturalismus und Idealismus/Hermeneutik. Unter Berücksichtigung dreier epistemologischer Ebenen – Essenzialisten/ontisch (wissenschaftlich), dekonstructiv (soziologisch) und ontologisch (emergent) – werden ausgewählte paradigmatische Tendenzen postuliert. Die erste Ebene ergibt Tendenzen wie die kartographische Kommunikation, die kartographische Semiotik, die analytische Kartographie und die kartographische Visualisierung, die alle zu der wissenschaftlich-empirischen Perspektive gehören. Zur zweiten Ebene gehört die kritische Kartographie, welche der kritischen Perspektive zugeordnet ist und die wissenschaftliche Standpunkte konfrontiert. Die so genannte post-repräsentative Kartographie entsteht aus der dritten Ebene im offenen Widerstand zur traditionellen repräsentativen Kartographie