Silent memory engrams as the basis for retrograde amnesia

Recent studies identified neuronal ensembles and circuits that hold specific memory information (memory engrams). Memory engrams are retained under protein synthesis inhibition-induced retrograde amnesia. These engram cells can be activated by optogenetic stimulation for full-fledged recall, but not by stimulation using natural recall cues (thus, amnesia). We call this state of engrams “silent engrams” and the cells bearing them “silent engram cells.” The retention of memory information under amnesia suggests that the time-limited protein synthesis following learning is dispensable for memory storage, but may be necessary for effective memory retrieval processes. Here, we show that the full-fledged optogenetic recall persists at least 8 d after learning under protein synthesis inhibition-induced amnesia. This long-term retention of memory information correlates with equally persistent retention of functional engram cell-to-engram cell connectivity. Furthermore, inactivation of the connectivity of engram cell ensembles with its downstream counterparts, but not upstream ones, prevents optogenetic memory recall. Consistent with the previously reported lack of retention of augmented synaptic strength and reduced spine density in silent engram cells, optogenetic memory recall under amnesia is stimulation strength-dependent, with low-power stimulation eliciting only partial recall. Finally, the silent engram cells can be converted to active engram cells by overexpression of α-p-21–activated kinase 1, which increases spine density in engram cells. These results indicate that memory information is retained in a form of silent engram under protein synthesis inhibition-induced retrograde amnesia and support the hypothesis that memory is stored as the specific connectivity between engram cells.RIKEN Brain Science InstituteHoward Hughes Medical InstituteJPB Foundatio

Addressing Hxstorical Amnesia: Proactively Combating Hxstorical Amnesia as a Means of Healing in Higher Education

In a political context characterized by the desire to “Make America Great Again,” the romanticization of the past and the erasure of narratives of marginalized communities affect how students experience and navigate higher education. Institutions of higher education were built on systems of colonization and imperialism and continue to benefit from the legacy of domination and subordination; this hxstory shapes student learning. The authors introduce hxstorical amnesia, its effects on student development, and methods of actively combating hxstorical amnesia in higher education. The authors explore ways to heal from hxstorical amnesia through community-care, cogenerative dialogues, and Sentipensante Pedagogy. By discussing the contemporary impacts of hxstorical amnesia on higher education and student learning, the authors hope to (re)write the narrative of higher education to underline the importance of the hxstories of marginalized communities

Against Amnesia: Re-Imagining Central Banking

The purpose of the present paper is to identify and challenge contemporary adherence to the core of the prevailing monetary policy consensus. This consensus consists of what we call the holy trinity of the inflation targeting paradigm: price stability as the primary goal of the central bank; central bank independence as the institutional arrangement; and the short-term interest rate as the operational target. Drawing on the literature on the history and political economy of central banking, we argue that the inability to think beyond this holy trinity stems from a severe case of collective institutional amnesia and comes at a heavy cost. We highlight that monetary policy can be deployed towards social purposes other than controlling inflation, in institutional configurations other than isolation from the rest of the government and with instruments other than interest rate manipulation. One central message is that whereas central banks are commonly portrayed as commanding only one instrument, in reality they have a battery of instruments at their disposal. We should think of central banking not as a hammer – a tool to hit inflation where it rears its ugly head – but as a Swiss army knife – a multi-purpose tool with many instruments. Doing so will help overcome the collective amnesia that stands in the way of an enlightened debate about how the power of central banking can – and perhaps should – be harnessed in the pursuit of collective social goals.1 Introduction 2 The Holy Trinity 3 Historical Specificity 3.1 Pre-War 3.2 Post-War, Pre-Inflation 3.3 Holy Trinity 3.4 Shoring up the Holy Trinity: The Tinbergen Rule 4 Beyond the Tinbergen Rule: A Swiss Army Knife Theory of Central Banking 4.1 Lender of Last Resort 4.2 Financial Market-Shaping I: Monetary Policy Implementation 4.3 Financial Market-Shaping II: Monetary Policy Transmission 5 Conclusion Reference

Solitary Amnesia as National Memory: From Habermas to Luhmann

The repressive mechanisms of collective memory have been the subject of a fierce debate in the human sciences - especially, but not exclusively, in the study of nationalism. This paper re-investigates the nature of national memory in the context of European nationalisms by drawing on contemporary national cases of remembering and forgetting. The explored instances are mobilized in the study of remembering/forgetting on a factual, rather than ideal level. Theoretically, it is argued that the Habermassian call for fostering ‘anamnestic solidarity’ with the past often fails in practice because of its normative undertones that disagree with Realpolitic demands. This is so because nationalist discourse, which serves to preserve the political interests of the national community, has to present itself to political forces that reside outside the community as a closed, autopoetic system akin to that theorized by Niklas Luhmann. Although the Luhmannian thesis (which would gesture towards the autonomisation of national memory) also fails to explain the nature of nationalist remembering/forgetting tout court, it allows more space for an exploration of nationalist self-presentation than Habermas’ normative stance. The argument in this study, which combines an appreciation of hermeneutics and autopoeia, is that the practice of (re)producing the ‘nation’s’ solitary amnesia enables nationalist discourse to respond to external political pressures. This presents the latter as a dialogical/hermeneutic project despite its solipsistic ‘façade’

Security Through Amnesia: A Software-Based Solution to the Cold Boot Attack on Disk Encryption

Disk encryption has become an important security measure for a multitude of clients, including governments, corporations, activists, security-conscious professionals, and privacy-conscious individuals. Unfortunately, recent research has discovered an effective side channel attack against any disk mounted by a running machine\cite{princetonattack}. This attack, known as the cold boot attack, is effective against any mounted volume using state-of-the-art disk encryption, is relatively simple to perform for an attacker with even rudimentary technical knowledge and training, and is applicable to exactly the scenario against which disk encryption is primarily supposed to defend: an adversary with physical access. To our knowledge, no effective software-based countermeasure to this attack supporting multiple encryption keys has yet been articulated in the literature. Moreover, since no proposed solution has been implemented in publicly available software, all general-purpose machines using disk encryption remain vulnerable. We present Loop-Amnesia, a kernel-based disk encryption mechanism implementing a novel technique to eliminate vulnerability to the cold boot attack. We offer theoretical justification of Loop-Amnesia's invulnerability to the attack, verify that our implementation is not vulnerable in practice, and present measurements showing our impact on I/O accesses to the encrypted disk is limited to a slowdown of approximately 2x. Loop-Amnesia is written for x86-64, but our technique is applicable to other register-based architectures. We base our work on loop-AES, a state-of-the-art open source disk encryption package for Linux.Comment: 13 pages, 4 figure

Hypnosis and memory: two hundred years of adventures and still going!

One of the most persistent beliefs about hypnosis is its ability to transcend mnemonic abilities. This belief has paved the way to the use of hypnosis in the clinical and legal arenas. The authors review the phenomena of hypnotic hypermnesia, pseudo-memories, and amnesia in light of current knowledge of hypnosis and memory. The investigation of the relation between hypnosis and memory processes has played an important role in our understanding of memory in action. Hypnosis provides a fertile field to explore the social, neuropsychological, and cognitive variables at play when individuals are asked to remember or to forget their past. We suggest promising avenues of research that may further our knowledge of the building blocks of memories and the mechanisms that leads to forgetfulness

An Investigation of the Factor Structure of the HARVARD GROUP SCALE OF HYPNOTIC SUSCEPTIBILITY, Form A (HGSHS:A)

In order to investigate the effects of the hypnotic state a standardized hypnosis session was conducted with 144 subjects in a controlled laboratory study. The induction of a hypnotic trance in the German version of the Harvard Group Scale of Hypnotic Susceptibility (HGSHS:A by Shor and Orne, 1962) was tape-recorded and used as the treatment. The HGSHS:A seems to be a reliable measure of suggestibility and hypnotizability. This is underlined by the consistent results of a factor analysis on the depths of hypnosis that is in agreement with former studies. Descriptive data analyses with a sufficient number of subjects of high and low suggestibility suggest that our hypnosis induction by tape is an effective method of producing a hypnotic trance. Analyses of within-subjects variables did not reveal any valid predictors of hypnotizability, thereby confirming the need of screening instruments such as the HGSHS

CADENCE’S DEFENSE MECHANISM IN RECOVERING HER LOST MEMORY IN WE WERE LIARS BY E. LOCKHART

LA PREECLAMPSIA DIFERENCIAS EPIDEMIOLÓGICAS ENTRE PREECLAMPSIA DE INICIO TEMPRANO (PRECOZ) CON PREECLAMPSIA DE INICIO TARDÍO DIFERENCIAS CLÍNICAS ENTRE PIP Y PIT INVASIÓN TROFOBLÁSTICA DEFICIENTE, LA HIPOPERFUSIÓN PLACENTARIA ANÁLISIS DE ANTECEDENTES INVESTIGATIVOS PLANTEAMIENTO OPERACIONAL CRONOGRAMA DEL TRABAJ