An Olfactory Receptor Pseudogene whose Function emerged in Humans

Human olfactory receptor, hOR17-210, is identified as a pseudogene in the human genome. Experimental data has shown however, that the gene product of cloned hOR17-210 cDNA was able to bind an odorant-binding protein and is narrowly tuned for excitation by cyclic ketones. Supported by experimental results, we used the bioinformatics methods of sequence analysis, computational protein modeling and docking, to show that functionality in this receptor is retained due to sequence-structure features not previously observed in mammalian ORs. This receptor does not possess the first two transmembrane helical domains (of seven typically seen in GPCRs). It however, possesses an additional TM that has not been observed in other human olfactory receptors. By incorporating these novel structural features, we created two putative models for this receptor. We also docked odor ligands that were experimentally shown to bind hOR17-210 model. We show how and why structural modifications of OR17-210 do not hinder this receptor's functionality. Our studies reveal that novel gene rearrangement that result in sequence and structural diversity in has a bearing on OR and GPCR function and evolution

How to Walk Your Dog in the Mountains with No Magic Leash

We describe a $O(\log n )$-approximation algorithm for computing the homotopic \Frechet distance between two polygonal curves that lie on the boundary of a triangulated topological disk. Prior to this work, algorithms were known only for curves on the Euclidean plane with polygonal obstacles. A key technical ingredient in our analysis is a $O(\log n)$-approximation algorithm for computing the minimum height of a homotopy between two curves. No algorithms were previously known for approximating this parameter. Surprisingly, it is not even known if computing either the homotopic \Frechet distance, or the minimum height of a homotopy, is in NP

Economic Impacts of Yellow Starthistle on California Ranchers

While the significant ecosystem damage caused by invasive weeds has been well documented, the economic impacts of specific invasive weed species are poorly understood. Yellow starthistle (Centaurea solstitialis L., hereafter YST) is the most widespread non-crop weed in California, resulting in serious damage to forage on natural range and improved pasture. A survey was administered to California cattle ranchers to investigate YST infestation rates, loss of forage quantity and value, and control or eradication efforts. The results were used to estimate county-wide economic losses for three focus counties, as well as state-wide economic losses, due to YST in California. Total losses of livestock forage value due to YST on private land for the state of California are estimated at $7.96 million/year, with ranchers’ out-of-pocket expenditures on YST control amounting to$9.45 million/year. Together, these costs are the equivalent of 6-7% of the total annual harvested pasture value for the state. Therefore, while the impacts are relatively small within the statewide total agricultural production system, costs due to YST infestation significantly constrain California’s livestock grazing sector.nonnative species, invasive weeds, yellow starthistle, ranching profitability, forage, livestock