Doing diabetes (Type 1): Symbiotic ethics and practices of care embodied in human-canine collaborations and olfactory sensitivity

This project studies domesticated healthy members of the canine species, who are educated to make use of their olfactory sensitivity in working with unwell members of the human species, and examines their situatedness, attempting also to comprehend their perspectives. The discipline of anthrozoology, newly added to the social sciences, emphasises a present and future need for an ethics that is involved in, allows for and advocates multispecies' dependencies and interdependencies.The chronically ill participants in this study are vulnerable experts in life’s uncertainties, and have become aware over time of multiple medical and social needs and practices. But, unlike the hypo-aware respondents documented in some studies of diabetes mellitus Type 1, these research participants are also conscious of their inability to recognise when their own fluctuating blood glucose levels are rising or falling to extremes, a loss of hyper- or hypo-awareness that puts their lives constantly at risk. Particular sources of better life management, increased self-esteem and means of social (re-)integration are trained medical alert assistance dogs who share the human home, and through keen olfactory sensitivity, are able to give advance warning when their partners’ blood sugar levels enter ‘danger’ zones. Research studies in anthrozoology and anthropology provide extensive literature on historic and contemporary human bonds with domestic and/or wild nonhuman animals. Equally, the sociology of health and illness continues to extend research into care practices performed to assist people with chronic illness. This study draws from these disciplines in order to add to multispecies ethnographic literature by exploring human-canine engagement, contribution and narrative, detailing the impact each member of the dyad has on the other, and by observing the 'doing' of the partnerships' daily routines to ward off hypo-glycaemia and hospitalisation. In addition, the project investigates the place, role and 'otherness' of a medical alert dog in a chronically ill person's understanding of 'the-body-they-do'. The perspective of symbolic interactionism assists in disentangling individual and shared meanings inherent in the interspecies collaboration by examining the mutualistic practices of care performed. The often-flexible moral boundaries that humans construct to differentiate between acceptable use and unacceptable exploitation of nonhuman animals are questioned within ethics-of-care theory, based on the concept of dogs as animate instruments and biomedical resources

Simultaneous Graph Representation Problems

Many graphs arising in practice can be represented in a concise and intuitive way that conveys their structure. For example: A planar graph can be represented in the plane with points for vertices and non-crossing curves for edges. An interval graph can be represented on the real line with intervals for vertices and intersection of intervals representing edges. The concept of ``simultaneity'' applies for several types of graphs: the idea is to find representations for two graphs that share some common vertices and edges, and ensure that the common vertices and edges are represented the same way. Simultaneous representation problems arise in any situation where two related graphs should be represented consistently. A main instance is for temporal relationships, where an old graph and a new graph share some common parts. Pairs of related graphs arise in many other situations. For example, two social networks that share some members; two schedules that share some events, overlap graphs of DNA fragments of two similar organisms, circuit graphs of two adjacent layers on a computer chip etc. In this thesis, we study the simultaneous representation problem for several graph classes. For planar graphs the problem is defined as follows. Let G1 and G2 be two graphs sharing some vertices and edges. The simultaneous planar embedding problem asks whether there exist planar embeddings (or drawings) for G1 and G2 such that every vertex shared by the two graphs is mapped to the same point and every shared edge is mapped to the same curve in both embeddings. Over the last few years there has been a lot of work on simultaneous planar embeddings, which have been called `simultaneous embeddings with fixed edges'. A major open question is whether simultaneous planarity for two graphs can be tested in polynomial time. We give a linear-time algorithm for testing the simultaneous planarity of any two graphs that share a 2-connected subgraph. Our algorithm also extends to the case of k planar graphs, where each vertex [edge] is either common to all graphs or belongs to exactly one of them. Next we introduce a new notion of simultaneity for intersection graph classes (interval graphs, chordal graphs etc.) and for comparability graphs. For interval graphs, the problem is defined as follows. Let G1 and G2 be two interval graphs sharing some vertices I and the edges induced by I. G1 and G2 are said to be `simultaneous interval graphs' if there exist interval representations of G1 and G2 such that any vertex of I is assigned to the same interval in both the representations. The `simultaneous representation problem' for interval graphs asks whether G1 and G2 are simultaneous interval graphs. The problem is defined in a similar way for other intersection graph classes. For comparability graphs and any intersection graph class, we show that the simultaneous representation problem for the graph class is equivalent to a graph augmentation problem: given graphs G1 and G2, sharing vertices I and the corresponding induced edges, do there exist edges E' between G1-I and G2-I such that the graph G1 U G_2 U E' belongs to the graph class. This equivalence implies that the simultaneous representation problem is closely related to other well-studied classes in the literature, namely, sandwich graphs and probe graphs. We give efficient algorithms for solving the simultaneous representation problem for interval graphs, chordal graphs, comparability graphs and permutation graphs. Further, our algorithms for comparability and permutation graphs solve a more general version of the problem when there are multiple graphs, any two of which share the same common graph. This version of the problem also generalizes probe graphs

Investigating the impact of anaesthesia and surgery on Alzheimer's disease and the potential therapeutic role of Statin

This study examines the impact of general anaesthesia, surgery and perioperative atorvastatin on Alzheimer's disease pathology in mice. A progressive neurodegenerative condition of complex aetiology, Alzheimer's is a common cause of dementia in humans but has no disease modifying treatment. Its long pre-symptomatic phase and lack of known biomarkers means asymptomatic individuals are exposed to modifiable risk factors in early life that influence disease progression and trajectory in the long term. Anaesthesia with surgery may be a modifiable risk factor. Neuroinflammation is a common feature of anaesthesia with surgery and Alzheimer's. Atorvastatin has potent anti-inflammatory pleiotropic effects that may be a useful perioperative intervention to modulate any acute on chronic neuroinflammatory interaction. The effects of the anaesthetic agents, isoflurane, nitrous oxide and xenon, were observed in immortal human cell lines that over-express APP and also in primary mouse hippocampal neurones incubated with amyloid beta. Altered distribution of APP, BACE-1 activity and differing expression of cleaved caspase-3 and BCL-2 were observed post exposure, with no change in gamma-secretase expression. The effects of anaesthesia, unilateral nephrectomy surgery and atorvastatin on pre-symptomatic and older APP23 mice (a murine model of Alzheimer's) were examined using behaviour techniques including Trace fear conditioning, Morris water maze and Y maze. Genotype dependent differences in learning were detected in different paradigms, as well as a post modifiable risk factor deficit in novel learning that was not seen after introduction of atorvastatin. Y maze performance showed changes in exploratory drive and working memory after the modifiable risk factor. Markers of neuroinflammation, synaptic function and amyloid beta pathology were quantified, showing a neuroinflammatory response and altered amyloid pathology, but no detectable change in synaptic marker after the modifiable risk factor. Anaesthesia with surgery does affect Alzheimer's neuropathology in mice, with perioperative atorvastatin changing both novel learning and working memory after anaesthesia with surgery.Open Acces

Reports to the President

A compilation of annual reports for the 1985-1986 academic year, including a report from the President of the Massachusetts Institute of Technology, as well as reports from the academic and administrative units of the Institute. The reports outline the year's goals, accomplishments, honors and awards, and future plans

Area-wide Integrated Pest Management

Extensive reliance on insecticides reduces biodiversity, contributes to pollinator decline, destroys habitat and threatens endangered species. This book offers a more effective application of the Integrated Pest Management (IPM) approach, on an area-wide (AW) or population-wide (AW-IPM) basis. It addresses the importance of problem-solving research, planning and baseline data collection, integrating tools for appropriate control strategies, and pilot trials. The 48 chapters authored by 184 experts cover advances in genetics, molecular biology, biological control, resistance management, modelling, automated surveillance and unmanned aerial release systems