The Number of Hierarchical Orderings

An ordered set-partition (or preferential arrangement) of n labeled elements represents a single ``hierarchy''; these are enumerated by the ordered Bell numbers. In this note we determine the number of ``hierarchical orderings'' or ``societies'', where the n elements are first partitioned into m <= n subsets and a hierarchy is specified for each subset. We also consider the unlabeled case, where the ordered Bell numbers are replaced by the composition numbers. If there is only a single hierarchy, we show that the average rank of an element is asymptotic to n/(4 log 2) in the labeled case and to n/4 in the unlabeled case.Comment: 7 page

Inference of Temporally Varying Bayesian Networks

When analysing gene expression time series data an often overlooked but crucial aspect of the model is that the regulatory network structure may change over time. Whilst some approaches have addressed this problem previously in the literature, many are not well suited to the sequential nature of the data. Here we present a method that allows us to infer regulatory network structures that may vary between time points, utilising a set of hidden states that describe the network structure at a given time point. To model the distribution of the hidden states we have applied the Hierarchical Dirichlet Process Hideen Markov Model, a nonparametric extension of the traditional Hidden Markov Model, that does not require us to fix the number of hidden states in advance. We apply our method to exisiting microarray expression data as well as demonstrating is efficacy on simulated test data

Towards a genome-wide transcriptogram: the Saccharomyces cerevisiae case

A genome modular classification that associates cellular processes to modules could lead to a method to quantify the differences in gene expression levels in different cellular stages or conditions: the transcriptogram, a powerful tool for assessing cell performance, would be at hand. Here we present a computational method to order genes on a line that clusters strongly interacting genes, defining functional modules associated with gene ontology terms. The starting point is a list of genes and a matrix specifying their interactions, available at large gene interaction databases. Considering the Saccharomyces cerevisiae genome we produced a succession of plots of gene transcription levels for a fermentation process. These plots discriminate the fermentation stage the cell is going through and may be regarded as the first versions of a transcriptogram. This method is useful for extracting information from cell stimuli/responses experiments, and may be applied with diagnostic purposes to different organisms

Optimal Hierarchical Layouts for Cache-Oblivious Search Trees

This paper proposes a general framework for generating cache-oblivious layouts for binary search trees. A cache-oblivious layout attempts to minimize cache misses on any hierarchical memory, independent of the number of memory levels and attributes at each level such as cache size, line size, and replacement policy. Recursively partitioning a tree into contiguous subtrees and prescribing an ordering amongst the subtrees, Hierarchical Layouts generalize many commonly used layouts for trees such as in-order, pre-order and breadth-first. They also generalize the various flavors of the van Emde Boas layout, which have previously been used as cache-oblivious layouts. Hierarchical Layouts thus unify all previous attempts at deriving layouts for search trees. The paper then derives a new locality measure (the Weighted Edge Product) that mimics the probability of cache misses at multiple levels, and shows that layouts that reduce this measure perform better. We analyze the various degrees of freedom in the construction of Hierarchical Layouts, and investigate the relative effect of each of these decisions in the construction of cache-oblivious layouts. Optimizing the Weighted Edge Product for complete binary search trees, we introduce the MinWEP layout, and show that it outperforms previously used cache-oblivious layouts by almost 20%.Comment: Extended version with proofs added to the appendi