Servicing the federation : the case for metadata harvesting

The paper presents a comparative analysis of data harvesting and distributed computing as complementary models of service delivery within large-scale federated digital libraries. Informed by requirements of flexibility and scalability of federated services, the analysis focuses on the identification and assessment of model invariants. In particular, it abstracts over application domains, services, and protocol implementations. The analytical evidence produced shows that the harvesting model offers stronger guarantees of satisfying the identified requirements. In addition, it suggests a first characterisation of services based on their suitability to either model and thus indicates how they could be integrated in the context of a single federated digital library

Extending functional databases for use in text-intensive applications

This thesis continues research exploring the benefits of using functional databases based around the functional data model for advanced database applications-particularly those supporting investigative systems. This is a growing generic application domain covering areas such as criminal and military intelligence, which are characterised by significant data complexity, large data sets and the need for high performance, interactive use. An experimental functional database language was developed to provide the requisite semantic richness. However, heavy use in a practical context has shown that language extensions and implementation improvements are required-especially in the crucial areas of string matching and graph traversal. In addition, an implementation on multiprocessor, parallel architectures is essential to meet the performance needs arising from existing and projected database sizes in the chosen application area. [Continues.

An implementation and evaluation of distributed information system based on the OSCA architecture guidelines

The concepts in this thesis discuss and evaluate the need for systems integration. As a conceptual architecture, the OSCATM architecture is investigated. A prototype of the CS Department distributed information system is built following the guidelines and standards of this conceptual architecture. This prototype is implemented in \u27C\u27. RPC (remote procedure call) is used for the communication channel to implement the distributed environment. Conclusions and results that were achieved by implementing this prototype are presented. The main outcome of this thesis is the introduction of the infrastructure to the GenSIF framework

When and how to develop domain-specific languages

Domain-specific languages (DSLs) are languages tailored to a specific application domain. They offer substantial gains in expressiveness and ease of use compared with general purpose programming languages in their domain of application. DSL development is hard, requiring both domain knowledge and language development expertise. Few people have both. Not surprisingly, the decision to develop a DSL is often postponed indefinitely, if considered at all, and most DSLs never get beyond the application library stage. While many articles have been written on the development of particular DSLs, there is very limited literature on DSL development methodologies and many questions remain regarding when and how to develop a DSL. To aid the DSL developer, we identify patterns in the decision, analysis, design, and implementation phases of DSL development. Our patterns try to improve on and extend earlier work on DSL design patterns, in particular by Spinellis (2001). We also discuss domain analysis tools and language development systems that may help to speed up DSL development. Finally, we state a number of open problems

Mapping lung cancer epithelial-mesenchymal transition states and trajectories with single-cell resolution.

Elucidating the spectrum of epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) states in clinical samples promises insights on cancer progression and drug resistance. Using mass cytometry time-course analysis, we resolve lung cancer EMT states through TGFβ-treatment and identify, through TGFβ-withdrawal, a distinct MET state. We demonstrate significant differences between EMT and MET trajectories using a computational tool (TRACER) for reconstructing trajectories between cell states. In addition, we construct a lung cancer reference map of EMT and MET states referred to as the EMT-MET PHENOtypic STAte MaP (PHENOSTAMP). Using a neural net algorithm, we project clinical samples onto the EMT-MET PHENOSTAMP to characterize their phenotypic profile with single-cell resolution in terms of our in vitro EMT-MET analysis. In summary, we provide a framework to phenotypically characterize clinical samples in the context of in vitro EMT-MET findings which could help assess clinical relevance of EMT in cancer in future studies