Affiliative Behavior, Ultrasonic Communication and Social Reward Are Influenced by Genetic Variation in Adolescent Mice

Social approach is crucial for establishing relationships among individuals. In rodents, social approach has been studied primarily within the context of behavioral phenomena related to sexual reproduction, such as mating, territory defense and parental care. However, many forms of social interaction occur before the onset of reproductive maturity, which suggests that some processes underlying social approach among juvenile animals are probably distinct from those in adults. We conducted a longitudinal study of social investigation (SI) in mice from two inbred strains to assess the extent to which genetic factors influence the motivation for young mice to approach one another. Early-adolescent C57BL/6J (B6) mice, tested 4–6 days after weaning, investigated former cage mates to a greater degree than BALB/cJ (BALB) mice, irrespective of the sex composition within an interacting pair. This strain difference was not due to variation in maternal care, the phenotypic characteristics of stimulus mice or sensitivity to the length of isolation prior to testing, nor was it attributable to a general difference in appetitive motivation. Ultrasonic vocalization (USV) production was positively correlated with the SI responses of mice from both strains. Interestingly, several USV characteristics segregated with the genetic background of young mice, including a higher average frequency and shorter duration for the USVs emitted by B6 mice. An assessment of conditioned place preference responses indicated that there was a strain-dependent difference in the rewarding nature of social contact. As adolescent mice aged, SI responses gradually became less sensitive to genetic background and more responsive to the particular sex of individuals within an interacting pair. We have thus identified a specific, genetic influence on the motivation of early-adolescent mice to approach one another. Consistent with classical theories of motivation, which propose a functional relationship between behavioral approach and reward, our findings indicate that reward is a proximal mechanism through which genetic factors affect social motivation during early adolescence

A psycho-ethological approach to social signal processing

The emerging field of social signal processing can benefit from a theoretical framework to guide future research activities. The present article aims at drawing attention to two areas of research that devoted considerable efforts to the understanding of social behaviour: ethology and social psychology. With a long tradition in the study of animal signals, ethology and evolutionary biology have developed theoretical concepts to account for the functional significance of signalling. For example, the consideration of divergent selective pressures responsible for the evolution of signalling and social cognition emphasized the importance of two classes of indicators: informative cues and communicative signals. Social psychology, on the other hand, investigates emotional expression and interpersonal relationships, with a focus on the mechanisms underlying the production and interpretation of social signals and cues. Based on the theoretical considerations developed in these two fields, we propose a model that integrates the processing of perceivable individual features (social signals and cues) with contextual information, and we suggest that output of computer-based processing systems should be derived in terms of functional significance rather than in terms of absolute conceptual meanin