2 research outputs found
Proto-Plasm: parallel language for adaptive and scalable modelling of biosystems
This paper discusses the design goals and the first developments of
Proto-Plasm, a novel computational environment to produce libraries
of executable, combinable and customizable computer models of natural and
synthetic biosystems, aiming to provide a supporting framework for predictive
understanding of structure and behaviour through multiscale geometric modelling
and multiphysics simulations. Admittedly, the Proto-Plasm platform is
still in its infancy. Its computational framework—language, model library,
integrated development environment and parallel engine—intends to provide
patient-specific computational modelling and simulation of organs and biosystem,
exploiting novel functionalities resulting from the symbolic combination of
parametrized models of parts at various scales. Proto-Plasm may define
the model equations, but it is currently focused on the symbolic description of
model geometry and on the parallel support of simulations. Conversely, CellML
and SBML could be viewed as defining the behavioural functions (the model
equations) to be used within a Proto-Plasm program. Here we exemplify
the basic functionalities of Proto-Plasm, by constructing a schematic
heart model. We also discuss multiscale issues with reference to the geometric
and physical modelling of neuromuscular junctions