Probing the dynamics of identified neurons with a data-driven modeling approach

In controlling animal behavior the nervous system has to perform within the operational limits set by the requirements of each specific behavior. The implications for the corresponding range of suitable network, single neuron, and ion channel properties have remained elusive. In this article we approach the question of how well-constrained properties of neuronal systems may be on the neuronal level. We used large data sets of the activity of isolated invertebrate identified cells and built an accurate conductance-based model for this cell type using customized automated parameter estimation techniques. By direct inspection of the data we found that the variability of the neurons is larger when they are isolated from the circuit than when in the intact system. Furthermore, the responses of the neurons to perturbations appear to be more consistent than their autonomous behavior under stationary conditions. In the developed model, the constraints on different parameters that enforce appropriate model dynamics vary widely from some very tightly controlled parameters to others that are almost arbitrary. The model also allows predictions for the effect of blocking selected ionic currents and to prove that the origin of irregular dynamics in the neuron model is proper chaoticity and that this chaoticity is typical in an appropriate sense. Our results indicate that data driven models are useful tools for the in-depth analysis of neuronal dynamics. The better consistency of responses to perturbations, in the real neurons as well as in the model, suggests a paradigm shift away from measuring autonomous dynamics alone towards protocols of controlled perturbations. Our predictions for the impact of channel blockers on the neuronal dynamics and the proof of chaoticity underscore the wide scope of our approach

Application of expert systems in project management decision aiding

The feasibility of developing an expert systems-based project management decision aid to enhance the performance of NASA project managers was assessed. The research effort included extensive literature reviews in the areas of project management, project management decision aiding, expert systems technology, and human-computer interface engineering. Literature reviews were augmented by focused interviews with NASA managers. Time estimation for project scheduling was identified as the target activity for decision augmentation, and a design was developed for an Integrated NASA System for Intelligent Time Estimation (INSITE). The proposed INSITE design was judged feasible with a low level of risk. A partial proof-of-concept experiment was performed and was successful. Specific conclusions drawn from the research and analyses are included. The INSITE concept is potentially applicable in any management sphere, commercial or government, where time estimation is required for project scheduling. As project scheduling is a nearly universal management activity, the range of possibilities is considerable. The INSITE concept also holds potential for enhancing other management tasks, especially in areas such as cost estimation, where estimation-by-analogy is already a proven method

Evaluating subset selection methods for use case points estimation

When the Use Case Points method is used for software effort estimation, users are faced with low model accuracy which impacts on its practical application. This study investigates the significance of using subset selection methods for the prediction accuracy of Multiple Linear Regression models, obtained by the stepwise approach. K-means, Spectral Clustering, the Gaussian Mixture Model and Moving Window are evaluated as appropriate subset selection techniques. The methods were evaluated according to several evaluation criteria and then statistically tested. Evaluation was performing on two independent datasets-which differ in project types and size. Both were cut by the hold-out method. If clustering were used, the training sets were clustered into 3 classes; and, for each of class, an independent regression model was created. These were later used for the prediction of testing sets. If Moving Window was used, then window of sizes 5, 10 and 15 were tested. The results show that clustering techniques decrease prediction errors significantly when compared to Use Case Points or moving windows methods. Spectral Clustering was selected as the best-performing solution, because it achieves a Sum of Squared Errors reduction of 32% for the first dataset, and 98% for the second dataset. The Mean Absolute Percentage Error is less than 1% for the second dataset for Spectral Clustering; 9% for moving window; and 27% for Use Case Points. When the first dataset is used, then prediction errors are significantly higher -53% for Spectral Clustering, but Use Case Points produces a 165% result. It can be concluded that this study proves subset selection techniques as a significant method for improving the prediction ability of linear regression models - which are used for software development effort prediction. It can also be concluded that the clustering method performs better than the moving window method

Robust detail-preserving signal extraction

We discuss robust filtering procedures for signal extraction from noisy time series. Particular attention is paid to the preservation of relevant signal details like abrupt shifts. moving averages and running medians are widely used but have shortcomings when large spikes (outliers) or trends occur. Modifications like modified trimmed means and linear median hybrid filters combine advantages of both approaches, but they do not completely overcome the difficulties. Better solutions can be based on robust regression techniques, which even work in real time because of increased computational power and faster algorithms. Reviewing previous work we present filters for robust signal extraction and discuss their merits for preserving trends, abrupt shifts and local extremes as well as for the removal of outliers. --

Optimal client recommendation for market makers in illiquid financial products

The process of liquidity provision in financial markets can result in prolonged exposure to illiquid instruments for market makers. In this case, where a proprietary position is not desired, pro-actively targeting the right client who is likely to be interested can be an effective means to offset this position, rather than relying on commensurate interest arising through natural demand. In this paper, we consider the inference of a client profile for the purpose of corporate bond recommendation, based on typical recorded information available to the market maker. Given a historical record of corporate bond transactions and bond meta-data, we use a topic-modelling analogy to develop a probabilistic technique for compiling a curated list of client recommendations for a particular bond that needs to be traded, ranked by probability of interest. We show that a model based on Latent Dirichlet Allocation offers promising performance to deliver relevant recommendations for sales traders.Comment: 12 pages, 3 figures, 1 tabl

Fundamental structures of dynamic social networks

Social systems are in a constant state of flux with dynamics spanning from minute-by-minute changes to patterns present on the timescale of years. Accurate models of social dynamics are important for understanding spreading of influence or diseases, formation of friendships, and the productivity of teams. While there has been much progress on understanding complex networks over the past decade, little is known about the regularities governing the micro-dynamics of social networks. Here we explore the dynamic social network of a densely-connected population of approximately 1000 individuals and their interactions in the network of real-world person-to-person proximity measured via Bluetooth, as well as their telecommunication networks, online social media contacts, geo-location, and demographic data. These high-resolution data allow us to observe social groups directly, rendering community detection unnecessary. Starting from 5-minute time slices we uncover dynamic social structures expressed on multiple timescales. On the hourly timescale, we find that gatherings are fluid, with members coming and going, but organized via a stable core of individuals. Each core represents a social context. Cores exhibit a pattern of recurring meetings across weeks and months, each with varying degrees of regularity. Taken together, these findings provide a powerful simplification of the social network, where cores represent fundamental structures expressed with strong temporal and spatial regularity. Using this framework, we explore the complex interplay between social and geospatial behavior, documenting how the formation of cores are preceded by coordination behavior in the communication networks, and demonstrating that social behavior can be predicted with high precision.Comment: Main Manuscript: 16 pages, 4 figures. Supplementary Information: 39 pages, 34 figure