10,787 research outputs found

    Anatomical information science

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    The Foundational Model of Anatomy (FMA) is a map of the human body. Like maps of other sorts – including the map-like representations we find in familiar anatomical atlases – it is a representation of a certain portion of spatial reality as it exists at a certain (idealized) instant of time. But unlike other maps, the FMA comes in the form of a sophisticated ontology of its objectdomain, comprising some 1.5 million statements of anatomical relations among some 70,000 anatomical kinds. It is further distinguished from other maps in that it represents not some specific portion of spatial reality (say: Leeds in 1996), but rather the generalized or idealized spatial reality associated with a generalized or idealized human being at some generalized or idealized instant of time. It will be our concern in what follows to outline the approach to ontology that is represented by the FMA and to argue that it can serve as the basis for a new type of anatomical information science. We also draw some implications for our understanding of spatial reasoning and spatial ontologies in general

    Perspectives on the revised Ghent criteria for the diagnosis of Marfan syndrome

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    Three international nosologies have been proposed for the diagnosis of Marfan syndrome (MFS): the Berlin nosology in 1988; the Ghent nosology in 1996 (Ghent-1); and the revised Ghent nosology in 2010 (Ghent-2). We reviewed the literature and discussed the challenges and concepts of diagnosing MFS in adults. Ghent-1 proposed more stringent clinical criteria, which led to the confirmation of MFS in only 32%-53% of patients formerly diagnosed with MFS according to the Berlin nosology. Conversely, both the Ghent-1 and Ghent-2 nosologies diagnosed MFS, and both yielded similar frequencies of MFS in persons with a causative FBN1 mutation (90% for Ghent-1 versus 92% for Ghent-2) and in persons not having a causative FBN1 mutation (15% versus 13%). Quality criteria for diagnostic methods include objectivity, reliability, and validity. However, the nosology-based diagnosis of MFS lacks a diagnostic reference standard and, hence, quality criteria such as sensitivity, specificity, or accuracy cannot be assessed. Medical utility of diagnosis implies congruency with the historical criteria of MFS, as well as with information about the etiology, pathogenesis, diagnostic triggers, prognostic triggers, and potential complications of MFS. In addition, social and psychological utilities of diagnostic criteria include acceptance by patients, patient organizations, clinicians and scientists, practicability, costs, and the reduction of anxiety. Since the utility of a diagnosis or exclusion of MFS is context-dependent, prioritization of utilities is a strategic decision in the process of nosology development. Screening tests for MFS should be used to identify persons with MFS. To confirm the diagnosis of MFS, Ghent-1 and Ghent-2 perform similarly, but Ghent-2 is easier to use. To maximize the utility of the diagnostic criteria of MFS, a fair and transparent process of nosology development is essential

    Predicting Post-Fire Change in West Virginia, USA from Remotely-Sensed Data

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    Prescribed burning is used in West Virginia, USA to return the important disturbance process of fire to oak and oak-pine forests. Species composition and structure are often the main goals for re-establishing fire with less emphasis on fuel reduction or reducing catastrophic wildfire. In planning prescribed fires land managers could benefit from the ability to predict mortality to overstory trees. In this study, wildfires and prescribed fires in West Virginia were examined to determine if specific landscape and terrain characteristics were associated with patches of high/moderate post-fire change. Using the ensemble machine learning approach of Random Forest, we determined that linear aspect was the most important variable associated with high/moderate post-fire change patches, followed by hillshade, aspect as class, heat load index, slope/aspect ratio (sine transformed), average roughness, and slope in degrees. These findings were then applied to a statewide spatial model for predicting post-fire change. Our results will help land managers contemplating the use of prescribed fire to spatially target landscape planning and restoration sites and better estimate potential post-fire effects

    Topological Foundations of Cognitive Science

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    A collection of papers presented at the First International Summer Institute in Cognitive Science, University at Buffalo, July 1994, including the following papers: ** Topological Foundations of Cognitive Science, Barry Smith ** The Bounds of Axiomatisation, Graham White ** Rethinking Boundaries, Wojciech Zelaniec ** Sheaf Mereology and Space Cognition, Jean Petitot ** A Mereotopological Definition of 'Point', Carola Eschenbach ** Discreteness, Finiteness, and the Structure of Topological Spaces, Christopher Habel ** Mass Reference and the Geometry of Solids, Almerindo E. Ojeda ** Defining a 'Doughnut' Made Difficult, N .M. Gotts ** A Theory of Spatial Regions with Indeterminate Boundaries, A.G. Cohn and N.M. Gotts ** Mereotopological Construction of Time from Events, Fabio Pianesi and Achille C. Varzi ** Computational Mereology: A Study of Part-of Relations for Multi-media Indexing, Wlodek Zadrozny and Michelle Ki

    Morphometric Analysis of Lake Langano Watershed using Geographic Information System

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    An understanding of watershed characteristics like areal, linear and relief aspect has paramount significance for watershed planning and management. An automatic extraction of these characteristics from digital elevation model is so effective and efficient. The main objective of this research work was Morphometric analysis of Lake Langano watershed characteristics from Digital Elevation model using GIS. This research work employs an automatic extraction of hydrological characteristics using Geographical Information system. The results of finding show that the watershed has highly permeable soil type which absorbs the water passing over the soil. Drainage texture of the watershed is very coarse and the watershed is less affected by erosion. There is high runoff in the watershed due to large number of overland flow length. The shape of the watershed is elongated shape and experiences low peak flow over longer duration of time. Circulatory value of the watershed indicates that lake Langano watershed is not under flood risk. Relief characteristics of the watershed indicate that most part of the watershed is characterized by gentle slope and the peak of south eastern part is characterized by steep slope. Keywords: DEM (digital elevation model), GIS (Geographic Information system), Morphometric analysis, Watershed characteristics. DOI: 10.7176/JEES/10-11-03 Publication date: November 30th 202

    Radiation and the stent: results from catheter-based radiation and radioactive stenting

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    Radiation and the stent: results from catheter-based radiation and radioactive stenting

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