The Design of GP 2

This papers defines the syntax and semantics of GP 2, a revised version of the graph programming language GP. New concepts are illustrated and explained with example programs. Changes to the first version of GP include an improved type system for labels, a built-in marking mechanism for nodes and edges, a more powerful edge predicate for conditional rule schemata, and functions returning the indegree and outdegree of matched nodes. Moreover, the semantics of the branching and loop statement have been simplified to allow their efficient implementation.Comment: In Proceedings WRS 2011, arXiv:1204.531

Structure based inhibitor design targeting glycogen phosphorylase b. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-d-glucopyranosylamines

Glycogen phosphorylase (GP) is a validated target for the development of new type 2 diabetes treatments. Exploiting the Zinc docking database, we report the in silico screening of 1888 β- D-glucopyranose-NH-CO-R putative GP inhibitors differing only in their R groups. CombiGlide and GOLD docking programs with different scoring functions were employed with the best performing methods combined in a “consensus scoring” approach to ranking of ligand binding affinities for the active site. Six selected candidates from the screening were then synthesized and their inhibitory potency was assessed both in vitro and ex vivo. Their inhibition constants’ values, in vitro, ranged from 5 to 377 µM while two of them were effective at causing inactivation of GP in rat hepatocytes at low µM concentrations. The crystal structures of GP in complex with the inhibitors were defined and provided the structural basis for their inhibitory potency and data for further structure based design of more potent inhibitors

Spherical Designs and Heights of Euclidean Lattices

We study the connection between the theory of spherical designs and the question of extrema of the height function of lattices. More precisely, we show that a full-rank n-dimensional Euclidean lattice, all layers of which hold a spherical 2-design, realises a stationary point for the height function, which is defined as the first derivative at 0 of the spectral zeta function of the associated flat torus. Moreover, in order to find out the lattices for which this 2-design property holds, a strategy is described which makes use of theta functions with spherical coefficients, viewed as elements of some space of modular forms. Explicit computations in dimension up to 7, performed with Pari/GP and Magma, are reported.Comment: 22 page

Segmental stabilizing exercises and low back pain: What is the evidence?

Study design: A systematic review of randomized controlled trials. Objectives: To evaluate the effectiveness of segmental stabilizing exercises for acute, subacute and chronic low back pain with regard to pain, recurrence of pain, disability and return to work. Methods: MEDLINE, EMBASE, CINAHL, Cochrane Controlled Trials Register, PEDro and article reference lists were searched from 1988 onward. Randomized controlled trials with segmental stabilizing exercises for adult low back pain patients were included. Four comparisons were foreseen: (1) effectiveness of segmental stabilizing exercises versus treatment by general practitioner (GP); (2) effectiveness of segmental stabilizing exercises versus other physiotherapy treatment; (3) effectiveness of segmental stabilizing exercises combined with other physiotherapy treatment versus treatment by GP and (4) effectiveness of segmental stabilizing exercises combined with other physiotherapy treatment versus other physiotherapy treatment. Results: Seven trials were included. For acute low back pain, segmental stabilizing exercises are equally effective in reducing short-term disability and pain and more effective in reducing long-term recurrence of low back pain than treatment by GP. For chronic low back pain, segmental stabilizing exercises are, in the short and long term, more effective than GP treatment and may be as effective as other physiotherapy treatments in reducing disability and pain. There is limited evidence that segmental stabilizing exercises additional to other physiotherapy treatment are equally effective for pain and more effective concerning disability than other physiotherapy treatments alone. There is no evidence concerning subacute low back pain. Conclusion: For low back pain, segmental stabilizing exercises are more effective than treatment by GP but they are not more effective than other physiotherapy interventions

Healthcare use among preschool children attending GP-led urgent care centres: a descriptive, observational study

© 2015 Published by the BMJ Publishing Group Limited.Objective Urgent care centres (UCCs) hours were developed with the aim of reducing inappropriate emergency department (ED) attendances in England. We aimed to examine the presenting complaint and outcomes of care in 2 general practitioner (GP)-led UCCs with extended opening times. Design Retrospective observational epidemiological study using routinely collected data. Setting 2 GP-led UCCs in London, colocated with a hospital ED. Participants All children aged under 5 years, attending 2 GP-led UCCs over a 3-year period. Outcomes Outcomes of care for the children including: primary diagnosis; registration status with a GP; destination following review within the UCC; and any medication prescribed. Comparison between GP-led UCC visit rates and routine general practices was also made. Results 3% (n=7747/282 947) of all attenders at the GP-led UCCs were children aged under 5 years. The most common reason for attendance was a respiratory illness (27%), followed by infectious illness (17%). 18% (n=1428) were either upper respiratory tract infections or viral infections. The majority (91%) of children attending were registered with a GP, and over two-thirds of attendances were out of hours. Overall 79% were seen and discharged home. Preschool children were more likely to attend their GP (47.0 per 100) than a GP-led UCC (9.4 per 100; 95% CI 8.9 to 10.0). Conclusions Two-thirds of preschool children attending GP-led UCCs do so out of hours, despite the majority being registered with a GP. The case mix is comparable with those presenting to an ED setting, with the majority managed exclusively by the GPs in the UCC before discharge home. Further work is required to understand the benefits of a GP-led urgent system in influencing future use of services especially emergency care

Automobile distribution center.

Tze Kin Hung Alfred."Architecture Department, Chinese University of Hong Kong, Master of Architecture Programme 1996-97, design report."Includes thesis report: Chinese automobile distribution center.Includes bibliographical references (leave 40 (1st gp.); leave 54 (2nd gp.))Chapter 1. --- BackgroundChapter 1.1 --- IntroductionChapter 1.2 --- Client: Porsche crisis and the Project C88Chapter 1.3 --- Programme BriefChapter 1.4 --- Schedule of AccommodationChapter 1.5 --- Site Selection and AnalysisChapter 2. --- Design ProcessChapter 2.1 --- Design PhilosophyChapter 2.2 --- Design evolutionChapter 2.3 --- Final SchemeChapter 3. --- Zoning/LayoutChapter 3.1 --- ZoningChapter 3.2 --- Internal LayoutChapter 4. --- StructureChapter 4.1 --- Structure EvolutionChapter 5. --- ServicesChapter 5.1 --- Ventilation /HVACChapter 5.2 --- DaylightingChapter 5.3 --- Life SafetyChapter 5.4 --- DrainageChapter 6. --- ConstructionChapter 6.1 --- ShowroomChapter 6.2 --- Maintenance CenterChapter 7. --- CostChapter 7.1 --- Sources of Finance 7.2 Cost AnalysisChapter 8. --- Special StudiesChapter 9. --- AcknowledgmentsChapter 10. --- Bibliograph