Applications of Artificial Intelligence in Biomedical Sciences

Η παρακάτω διπλωματική εργασία αποτελεί μια εκτεταμένη βιβλιογραφική ανασκόπηση των Εφαρμογών της Τεχνητής Νοημοσύνης στις Βιοϊατρικές Επιστήμες. Πιο αναλυτικά, εστιάζει στις εφαρμογές της Τεχνητής Νοημοσύνης στην Ανάπτυξη Νέων Φαρμάκων, στην Ανάλυση Εικόνων (Image Analysis), στην Ιατρική Φροντίδα (Healthcare), στα Radiomics και στις Κλινικές Δοκιμές (Clinical Trials). Η Τεχνητή Νοημοσύνη έχει αποτελέσει ακρογωνιαίο λίθο στην ανάπτυξη πολλών άλλων επιστημών και σύμφωνα με πλήθος ειδικών και ερευνητών θεωρείτο η μεγαλύτερη ανακάλυψη του αιώνα. Στο πρώτο κεφάλαιο αναλύεται η ιστορία της Τεχνητής Νοημοσύνης καθώς και ο ορισμός αυτής. Στο επόμενο κεφάλαιο γίνεται η αναζήτηση της βιβλιογραφίας στην οποία παρουσιάζονται τα πρώτα βήματα που έγιναν ώστε να δημιουργηθεί η επιστήμη που γνωρίζουμε σήμερα. Έπειτα αναλύονται οι εφαρμογές αυτής σε διάφορους τομείς καθώς και η συμβολή της στην περαιτέρω ανάπτυξη τους. Τέλος, στο τελευταίο κεφάλαιο, κεφάλαιο 4, γίνεται η συζήτηση πάνω σε ό,τι ειπώθηκε προηγουμένως καθώς και προτείνονται νέοι δρόμοι ανάπτυξης της επιστήμης της Τεχνητής Νοημοσύνης.In this dissertation is presented the contribution of AI in biomedical sciences and particularly in drug development, image analysis, healthcare, radiomics and clinical trials. It will be demonstrated the general theoretical context behind the evolution of Artificial Intelligence, as well as its applications. The first chapter, analyzes the history of Artificial Intelligence starting with its definition. The second chapter includes a review of the literature underlining some of the most important milestones of the creation of Artificial Intelligence. As AI has been conducive to the development of many fields it has been characterized by many experts as the biggest innovation of the century. Thus, the third chapter presents the different methods of machine learning used in those fields. In the last chapter of the thesis, chapter 4, is represented a discussion about the findings of the thesis as well as about some new ways that Artificial Intelligence could be beneficial

Drug Repurposing

This book focuses on various aspects and applications of drug repurposing, the understanding of which is important for treating diseases. Due to the high costs and time associated with the new drug discovery process, the inclination toward drug repurposing is increasing for common as well as rare diseases. A major focus of this book is understanding the role of drug repurposing to develop drugs for infectious diseases, including antivirals, antibacterial and anticancer drugs, as well as immunotherapeutics

Translational Research in Cancer

Translational research in oncology benefits from an abundance of knowledge resulting from genome-scale studies concerning the molecular pathways involved in tumorigenesis. Translational oncology represents a bridge between basic research and clinical practice in cancer medicine. The vast majority of cancer cases are due to environmental risk factors. Many of these environmental factors are controllable lifestyle choices. Experimental cancer treatments are studied in clinical trials to compare the proposed treatment to the best existing treatment through translational research. The key features of the book include: 1) New screening for the development of radioprotectors: radioprotection and anti-cancer effect of β-Glucan (Enterococcus faecalis) 2) Translational perspective on hepatocellular carcinoma 3) Brachytherapy for endometrial cancer 4) Discovery of small molecule inhibitors for histone methyltransferases in cance