6,821 research outputs found
UMSL Bulletin 2023-2024
The 2023-2024 Bulletin and Course Catalog for the University of Missouri St. Louis.https://irl.umsl.edu/bulletin/1088/thumbnail.jp
Slitless spectrophotometry with forward modelling: principles and application to atmospheric transmission measurement
In the next decade, many optical surveys will aim to tackle the question of
dark energy nature, measuring its equation of state parameter at the permil
level. This requires trusting the photometric calibration of the survey with a
precision never reached so far, controlling many sources of systematic
uncertainties. The measurement of the on-site atmospheric transmission for each
exposure, or on average for each season or for the full survey, can help reach
the permil precision for magnitudes. This work aims at proving the ability to
use slitless spectroscopy for standard star spectrophotometry and its use to
monitor on-site atmospheric transmission as needed, for example, by the Vera C.
Rubin Observatory Legacy Survey of Space and Time supernova cosmology program.
We fully deal with the case of a disperser in the filter wheel, which is the
configuration chosen in the Rubin Auxiliary Telescope. The theoretical basis of
slitless spectrophotometry is at the heart of our forward model approach to
extract spectroscopic information from slitless data. We developed a publicly
available software called Spectractor (https://github.com/LSSTDESC/Spectractor)
that implements each ingredient of the model and finally performs a fit of a
spectrogram model directly on image data to get the spectrum. We show on
simulations that our model allows us to understand the structure of
spectrophotometric exposures. We also demonstrate its use on real data, solving
specific issues and illustrating how our procedure allows the improvement of
the model describing the data. Finally, we discuss how this approach can be
used to directly extract atmospheric transmission parameters from data and thus
provide the base for on-site atmosphere monitoring. We show the efficiency of
the procedure on simulations and test it on the limited data set available.Comment: 30 pages, 36 figures, submitted to Astronomy and Astrophysic
Complexity Science in Human Change
This reprint encompasses fourteen contributions that offer avenues towards a better understanding of complex systems in human behavior. The phenomena studied here are generally pattern formation processes that originate in social interaction and psychotherapy. Several accounts are also given of the coordination in body movements and in physiological, neuronal and linguistic processes. A common denominator of such pattern formation is that complexity and entropy of the respective systems become reduced spontaneously, which is the hallmark of self-organization. The various methodological approaches of how to model such processes are presented in some detail. Results from the various methods are systematically compared and discussed. Among these approaches are algorithms for the quantification of synchrony by cross-correlational statistics, surrogate control procedures, recurrence mapping and network models.This volume offers an informative and sophisticated resource for scholars of human change, and as well for students at advanced levels, from graduate to post-doctoral. The reprint is multidisciplinary in nature, binding together the fields of medicine, psychology, physics, and neuroscience
The existence of subspace designs
We prove the existence of subspace designs with any given parameters,
provided that the dimension of the underlying space is sufficiently large in
terms of the other parameters of the design and satisfies the obvious necessary
divisibility conditions. This settles an open problem from the 1970s. Moreover,
we also obtain an approximate formula for the number of such designs.Comment: 61 page
2023-2024 Undergraduate Catalog
2023-2024 undergraduate catalog for Morehead State University
Development and application of methodologies and infrastructures for cancer genome analysis within Personalized Medicine
[eng] Next-generation sequencing (NGS) has revolutionized biomedical sciences, especially in the area of cancer. It has nourished genomic research with extensive collections of sequenced genomes that are investigated to untangle the molecular bases of disease, as well as to identify potential targets for the design of new treatments. To exploit all this information, several initiatives have emerged worldwide, among which the Pan-Cancer project of the ICGC (International Cancer Genome Consortium) stands out. This project has jointly analyzed thousands of tumor genomes of different cancer types in order to elucidate the molecular bases of the origin and progression of cancer. To accomplish this task, new emerging technologies, including virtualization systems such as virtual machines or software containers, were used and had to be adapted to various computing centers. The portability of this system to the supercomputing infrastructure of the BSC (Barcelona Supercomputing Center) has been carried out during the first phase of the thesis. In parallel, other projects promote the application of genomics discoveries into the clinics. This is the case of MedPerCan, a national initiative to design a pilot project for the implementation of personalized medicine in oncology in Catalonia. In this context, we have centered our efforts on the methodological side, focusing on the detection and characterization of somatic variants in tumors. This step is a challenging action, due to the heterogeneity of the different methods, and an essential part, as it lays at the basis of all downstream analyses.
On top of the methodological section of the thesis, we got into the biological interpretation of the results to study the evolution of chronic lymphocytic leukemia (CLL) in a close collaboration with the group of Dr. Elías Campo from the Hospital Clínic/IDIBAPS. In the first study, we have focused on the Richter transformation (RT), a transformation of CLL into a high-grade lymphoma that
leads to a very poor prognosis and with unmet clinical needs. We found that RT has greater genomic, epigenomic and transcriptomic complexity than CLL. Its genome may reflect the imprint of therapies that the patients received prior to RT, indicating the presence of cells exposed to these mutagenic treatments which later expand giving rise to the clinical manifestation of the disease. Multiple NGS- based techniques, including whole-genome sequencing and single-cell DNA and RNA sequencing, among others, confirmed the pre-existence of cells with the RT characteristics years before their manifestation, up to the time of CLL diagnosis. The transcriptomic profile of RT is remarkably different from that of CLL. Of particular importance is the overexpression of the OXPHOS pathway, which could be used as a therapeutic vulnerability. Finally, in a second study, the analysis of a case of CLL in a young adult, based on whole genome and single-cell sequencing at different times of the disease, revealed that the founder clone of CLL did not present any somatic driver mutations and was characterized by germline variants in ATM, suggesting its role in the origin of the disease, and highlighting the possible contribution of germline variants or other non-genetic mechanisms in the initiation of CLL
Assouad-Nagata dimension and gap for ordered metric spaces
We prove that all spaces of finite Assouad-Nagata dimension admit a good
order for Travelling Salesman Problem, and provide sufficient conditions under
which the converse is true. We formulate a conjectural characterisation of
spaces of finite -dimension, which would yield a gap statement for the
efficiency of orders on metric spaces. Under assumption of doubling, we prove a
stronger gap phenomenon about all orders on a given metric space.Comment: 27 pages. This paper appeared originally as the second part of first
versions of arXiv:2011.01732. Now the paper is split it two parts, the first
one "Spaces that can be ordered effectively: virtually free groups and
hyperbolicity" arXiv:2011.01732, and the second part her
Cluster expansion methods in rigorous statistical mechanics
This draft is intended to be used as class notes for a grad course on
rigorous statistical mechanics at math department of UFMG. It should be
considered as a very prelimivary version and a work in progress. Several
chapters lack references, exercises, and revision
On interval colourings of graphs
An interval colouring of a graph is a proper colouring such that the set of colours of edges incident to any given
vertex forms an interval of . The interval thickness of
a graph is the smallest integer such that can be edge-partitioned
into interval colourable graphs, and is the largest interval
thickness over graphs on vertices. We show that for some . In particular this answers
a question by Asratian, Casselgren, and Petrosyan.
In the second part of the paper, we confirm a conjecture of Axenovich that
the maximum number of colours used in an interval colouring of a planar graph
on vertices is at most .Comment: 11 pages, this work has been superseded and incorporated into
arXiv:2303.0478
2023-2024 Boise State University Undergraduate Catalog
This catalog is primarily for and directed at students. However, it serves many audiences, such as high school counselors, academic advisors, and the public. In this catalog you will find an overview of Boise State University and information on admission, registration, grades, tuition and fees, financial aid, housing, student services, and other important policies and procedures. However, most of this catalog is devoted to describing the various programs and courses offered at Boise State
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