PolarLight: a CubeSat X-ray Polarimeter based on the Gas Pixel Detector

The gas pixel detector (GPD) is designed and developed for high-sensitivity astronomical X-ray polarimetry, which is a new window about to open in a few years. Due to the small mass, low power, and compact geometry of the GPD, we propose a CubeSat mission Polarimeter Light (PolarLight) to demonstrate and test the technology directly in space. There is no optics but a collimator to constrain the field of view to 2.3 degrees. Filled with pure dimethyl ether (DME) at 0.8 atm and sealed by a beryllium window of 100 micron thick, with a sensitive area of about 1.4 mm by 1.4 mm, PolarLight allows us to observe the brightest X-ray sources on the sky, with a count rate of, e.g., ~0.2 counts/s from the Crab nebula. The PolarLight is 1U in size and mounted in a 6U CubeSat, which was launched into a low Earth Sun-synchronous orbit on October 29, 2018, and is currently under test. More launches with improved designs are planned in 2019. These tests will help increase the technology readiness for future missions such as the enhanced X-ray Timing and Polarimetry (eXTP), better understand the orbital background, and may help constrain the physics with observations of the brightest objects.Comment: Accepted for publication in Experimental Astronom

Performance Enhancement in Copper Twisted Pair Cable Communications

The thesis focuses on the area of copper twisted pair based wireline communications. As one of the most widely deployed communication media, the copper twisted pair cable plays an important role in the communication network cabling infrastructure. This thesis looks to exploit diversity to improve twisted pair channels for data communications in two common application areas, namely Ethernet over Twisted Paris and digital subscriber line over twisted pair based telephone network. The first part of the thesis addresses new approaches to next generation Ethernet over twisted pair cable. The coming challenge for Ethernet over twisted pair cable is to realise a higher data rate beyond the 25/40GBASE-T standard, in relatively short reach scenarios. The straight-forward approaches, such as improving cable quality and extending frequency bandwidth, are unlikely to provide significant improvement in terms of data rate. However, other system diversities, such as spectrum utilization are yet to be fully exploited, so as to meet the desired data rate performance. The current balanced transmission over the structured twisted pair cable and its parallel single-in-single-out channel model is revisited and formulated as a full-duplex multiple-in-multiple-out (MIMO) channel model. With a common ground (provided by the cable shield), the balanced transmission is converted into unbalanced transmission, by replacing the differential-mode excitation with single-ended excitation. In this way, MIMO adoption may offer spectrum utilization advantages due to the doubled number of the channels. The S-parameters of the proposed MIMO channel model is obtained through the full wave electromagnetic simulation of a short CAT7A cable. The channel models are constructed from the resulting S-parameters, also the corresponding theoretical capacity is evaluated by exploiting different diversity scenarios. With higher spectrum efficiency, the orthogonal-frequency-division-multiplexing (OFDM) modulation can significantly improve the theoretical capacity compared with single-carrier modulation, where the channel frequency selectivity is aided. The MIMO can further enhance the capacity by minimising the impact of the crosstalk. When the crosstalk is properly handled under the unbalanced transmission, this thesis shows that the theoretical capacity of the EoTP cable can reach nearly 200GBit/s. In order to further extend the bandwidth capability of twisted pair cables, Phantom Mode transmission is studied, aiming at creating more channels under balanced transmission operation. The second part of the thesis focuses on the research of advanced scheduling algorithms for VDSL2 QoS enhancement. For VDSL2 broadband access networks, multi-user optimisation techniques have been developed, so as to improve the basic data rate performance. Spectrum balancing improves the network performance by optimising users transmit power spectra as the resource allocation, to mitigate the impact from the crosstalk. Aiming at enhancing the performance for the upstream VDSL2 service, where the users QoS demand is not known by all other users, a set of autonomous spectrum balancing algorithms is proposed. These optimise users transmit power spectra locally with only direct channel state information. To prevent selfish behaviour, the concept of a virtual user is introduced to represent the impact on both crosstalk interference and queueing status of other users. Moreover, novel algorithms are developed to determine the parameters and the weight of the virtual user. Another type of resource allocation in the VDSL2 network is crosstalk cancellation by centralised signal coordination. The history of the data queue is considered as a time series, on which different smooth filter characteristics are investigated in order to investigate further performance improvement. The use of filter techniques accounts for both the instantaneous queue length and also the previous data to determine the most efficient dynamic resource allocation. With the help of this smoothed dynamic resource allocation, the network will benefit from both reduced signalling communication and improved delay performance.The proposed algorithms are verified by numerical experiments

A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer

Background: miR‑346 was identified as an activator of Androgen Receptor (AR) signalling that associates with DNA damage response (DDR)‑linked transcripts in prostate cancer (PC). We sought to delineate the impact of miR‑346 on DNA damage, and its potential as a therapeutic agent. Methods: RNA‑IP, RNA‑seq, RNA‑ISH, DNA fibre assays, in vivo xenograft studies and bioinformatics approaches were used alongside a novel method for amplification‑free, single nucleotide‑resolution genome‑wide mapping of DNA breaks (INDUCE‑seq). Results: miR‑346 induces rapid and extensive DNA damage in PC cells ‑ the first report of microRNA‑induced DNA damage. Mechanistically, this is achieved through transcriptional hyperactivation, R‑loop formation and replication stress, leading to checkpoint activation and cell cycle arrest. miR‑346 also interacts with genome‑protective lncRNA NORAD to disrupt its interaction with PUM2, leading to PUM2 stabilisation and its increased turnover of DNA damage response (DDR) transcripts. Confirming clinical relevance, NORAD expression and activity strongly correlate with poor PC clinical outcomes and increased DDR in biopsy RNA‑seq studies. In contrast, miR‑346 is associated with improved PC survival. INDUCE‑seq reveals that miR‑346‑induced DSBs occur preferentially at binding sites of the most highly‑transcriptionally active transcription factors in PC cells, including c‑Myc, FOXA1, HOXB13, NKX3.1, and importantly, AR, resulting in target transcript downregulation. Further, RNA‑seq reveals widespread miR‑346 and shNORAD dysregulation of DNA damage, replication and cell cycle processes. NORAD drives target‑directed miR decay (TDMD) of miR‑346 as a novel genome protection mechanism: NORAD silencing increases mature miR‑346 levels by several thousand‑fold, and WT but not TDMD‑mutant NORAD rescues miR‑346‑induced DNA damage. Importantly, miR‑346 sensitises PC cells to DNA‑damaging drugs including PARP inhibitor and chemotherapy, and induces tumour regression as a monotherapy in vivo, indicating that targeting miR‑346:NORAD balance is a valid therapeutic strategy

VCSEL and Integration Techniques for Wavelength-Multiplexed Optical Interconnects

GaAs-based vertical-cavity surface-emitting lasers (VCSELs) are dominating short-reach optical interconnects (OIs) due to their high modulation speed, low power consumption, circular output beam and low fabrication cost. Such OIs provide the high bandwidth connectivity needed for interconnecting servers and switches in data centers. With the rapidly increasing use of Internet-based applications and services, higher bandwidth connectivity and higher aggregate capacity VCSEL-based OIs are needed. Until now, this has been achieved mostly through an increase of the lane rate by higher speed VCSELs and higher order modulation formats. Furthermore, spatial-division-multiplexing has proven effective for increasing the aggregate capacity. Much higher capacity can be achieved by multiple wavelengths per fiber, known as wavelength-divisionmultiplexing (WDM). Moreover, smaller footprint and higher bandwidth density WDM transceivers can be built using monolithic multi-wavelength VCSEL arrays with densely spaced VCSELs. This requires a VCSEL technology where the wavelength of individual VCSELs can be precisely set in a post-epitaxial growth fabrication process and a photonic integrated circuit (PIC) for multiplexing and fiber coupling. Flip-chip integration over grating couplers (GCs) is considered for interfacing VCSELs with waveguides on the PIC. In this thesis, an intra-cavity phase tuning technique is demonstrated for setting the resonance wavelength of VCSELs in a monolithic array with an accuracy in spacing of <1 nm. Uniform performance over the array is achieved by spectral matching and balancing of mirror reflectances, optical confinement factor and optical gain. Single transverse and polarization mode VCSELs, as required for flip-chip integration over GCs, with a record output power of 6 mW are also demonstrated.Finally, an investigation of angled flip-chip integration of a VCSEL over a GC on a silicon photonic integrated circuit (Si-PIC) is presented. Dependencies of coupling efficiency and optical feedback on flip-chip angle and size of the VCSEL die are studied using numerical FDTD simulations. Moreover, flip-chip integration of a VCSEL over a GC on a Si-PIC is experimentally demonstrated. The insertion loss from the VCSEL at the input GC to a singlemode fiber, multimode fiber or flip-chip integrated photodetector over the output GC was measured and quantified. The latter forms an on-PIC optical link

Space station data system analysis/architecture study. Task 2: Options development DR-5. Volume 1: Technology options

The second task in the Space Station Data System (SSDS) Analysis/Architecture Study is the development of an information base that will support the conduct of trade studies and provide sufficient data to make key design/programmatic decisions. This volume identifies the preferred options in the technology category and characterizes these options with respect to performance attributes, constraints, cost, and risk. The technology category includes advanced materials, processes, and techniques that can be used to enhance the implementation of SSDS design structures. The specific areas discussed are mass storage, including space and round on-line storage and off-line storage; man/machine interface; data processing hardware, including flight computers and advanced/fault tolerant computer architectures; and software, including data compression algorithms, on-board high level languages, and software tools. Also discussed are artificial intelligence applications and hard-wire communications

High Performance Optical Transmitter Ffr Next Generation Supercomputing and Data Communication

High speed optical interconnects consuming low power at affordable prices are always a major area of research focus. For the backbone network infrastructure, the need for more bandwidth driven by streaming video and other data intensive applications such as cloud computing has been steadily pushing the link speed to the 40Gb/s and 100Gb/s domain. However, high power consumption, low link density and high cost seriously prevent traditional optical transceiver from being the next generation of optical link technology. For short reach communications, such as interconnects in supercomputers, the issues related to the existing electrical links become a major bottleneck for the next generation of High Performance Computing (HPC). Both applications are seeking for an innovative solution of optical links to tackle those current issues. In order to target the next generation of supercomputers and data communication, we propose to develop a high performance optical transmitter by utilizing CISCO Systems®\u27s proprietary CMOS photonic technology. The research seeks to achieve the following outcomes: 1. Reduction of power consumption due to optical interconnects to less than 5pJ/bit without the need for Ring Resonators or DWDM and less than 300fJ/bit for short distance data bus applications. 2. Enable the increase in performance (computing speed) from Peta-Flop to Exa-Flops without the proportional increase in cost or power consumption that would be prohibitive to next generation system architectures by means of increasing the maximum data transmission rate over a single fiber. 3. Explore advanced modulation schemes such as PAM-16 (Pulse-Amplitude-Modulation with 16 levels) to increase the spectrum efficiency while keeping the same or less power figure. This research will focus on the improvement of both the electrical IC and optical IC for the optical transmitter. An accurate circuit model of the optical device is created to speed up the performance optimization and enable co-simulation of electrical driver. Circuit architectures are chosen to minimize the power consumption without sacrificing the speed and noise immunity. As a result, a silicon photonic based optical transmitter employing 1V supply, featuring 20Gb/s data rate is fabricated. The system consists of an electrical driver in 40nm CMOS and an optical MZI modulator with an RF length of less than 0.5mm in 0.13&mu m SOI CMOS. Two modulation schemes are successfully demonstrated: On-Off Keying (OOK) and Pulse-Amplitude-Modulation-N (PAM-N N=4, 16). Both versions demonstrate signal integrity, interface density, and scalability that fit into the next generation data communication and exa-scale computing. Modulation power at 20Gb/s data rate for OOK and PAM-16 of 4pJ/bit and 0.25pJ/bit are achieved for the first time of an MZI type optical modulator, respectively

Impulse radio ultra wideband over fiber techniques for broadband in-building network applications

In recent years, the demand for high bandwidth and mobility from the end users has been continuously growing. To satisfy this demand, broadband communication technologies that combined the benefit of both wired and wireless are considered as vital solutions. These hybrid optical wireless solutions enable multi-Gbit/s transmission as well as adequate flexibility in terms of mobility. Optical fiber is the ideal medium for such hybrid solution due its signal transparency and wide bandwidth. On the other hand, ultra wideband(UWB) radio over optical fiber technology is considered to be one of the key promising technologies for broadband communication and sensor network applications. The growing interest for UWB is mainly due to its numerous attractive features, such as low power spectral density, tolerance to multipath fading, low probability of interception, coexistence with other wireless services and capability of providing cost-effective > 1 Gb/s transmission. The main idea of UWB over fiber is to deliver UWB radio signals over optical channels, where the optical part serves as a backbone communication infrastructure to carry the UWB signal with a bandwidth of several GHz. This enables multiple novel applications such as: range extension of high speed wireless personal area networks (WPANs), low cost distributed antenna systems, secure and intelligent networks, or delivering broadband services to remote areas. In particular, this thesis deals with novel concepts on shaping and generation of IR-UWB pulses, theoretical and experimental demonstrations over different fiber types, routing of integrated wired/wireless IR-UWB services and effect of fiber types on ranging/localization of IR-UWB-over-fiber systems. Accordingly, this thesis investigates techniques for delivery of high data rate wireless services using impulse radio ultra wideband (IR-UWB) over fiber technology for both access and in-building network applications. To effectively utilize the emission mask imposed for UWB technologies by the Federal Communications Commission(FCC), novel pulse shaping techniques have been investigated and experimentally demonstrated. Comparison of the proposed pulses with conventional ones in terms of the compliance to the FCC-mask requirements, spectral power efficiencies and wireless coverage has been theoretically studied. Simple and efficient optical generation of the new pulse has been experimentally demonstrated. Furthermore, performance evaluation of 2 Gb/s transmission of IR-UWB over different types of fiber such as 25 km silica single-mode, 4.4 km silica multi-mode and 100 m plastic heavily-multi-mode fiber have been performed. To improve the functionalities of in-building networks for the delivery of wireless services; techniques that provide flexibility in terms of dynamic capacity allocation have been investigated. By employing wavelength conversion based on cross-gain modulation in optical semiconductor amplifiers(SOA), routing of three optical channels of IR-UWB over fiber system has been experimentally realized. To reduce the cost of the overall system and share the optical infrastructure, an integrated testbed for wired baseband data and wireless IR-UWB over 1 km SMF-28 fiber has been developed. Accordingly, 1.25 Gb/s wired baseband and 2 Gb/s wireless IR-UWB data have been successfully transmitted over the testbed. Furthermore, to improve the network flexibility, routing of both wired baseband and wireless signals has been demonstrated. Additionally, the ranging and localization capability of IR-UWB over fiber for in-door wireless picocells have been investigated. The effect of different fiber types (4 km SMF, 4.4 km GI-MMF and 100 m PF GI-POF) on the accuracy of the range estimation using time-of-arrival (ToA) ranging technique has been studied. A high accuracy in terms of cm level was achieved due to the combined effect of high bandwidth IR-UWB pulses, short reach fiber and low chromatic dispersion at 1300nm wavelength. Furthermore, ranging/ localization using IR-UWB over fiber system provides additional benefit of centralizing complex processing algorithms, simplifying radio access points, relaxing synchronization requirement, enabling energy-efficient and efficient traffic management networks. All the concepts, design and system experiments presented in this thesis underline the strong potential of IR-UWB for over optical fiber(silica and plastic) techniques for future smart, capacity and energy-efficient broadband in-building network applications