Influence of prenatal maternal stress, maternal plasma cortisol and cortisol in the amniotic fluid on birth outcomes and child temperament at 3 months

This prospective, longitudinal study aimed to investigate relationships between indicators of maternal prenatal stress, infant birth outcomes and early temperament. We examined the pattern of associations and postulated pathways between physiological (cortisol plasma concentrations) and self-report indices (stress, anxiety) of maternal prenatal stress, cortisol in the amniotic fluid, birth outcomes and infant temperament at 3 months. The sample consisted of 158 women undergoing amniocentesis in the 2nd trimester of pregnancy. Questionnaire measures of maternal stress and anxiety were found to be unrelated to cortisol in plasma or amniotic fluid. Maternal cortisol was related to amniotic cortisol, which in turn was associated with lower birth weight. Birth weight predicted infant fear and distress to limitation at 3 months old. We found trend-like indirect effects of amniotic fluid on infant distress to limitation and fear via birth weight. This is one of the few studies to simultaneously assess the role of maternal and amniotic fluid cortisol on birth outcomes and infant emotional development. The results suggest that foetal cortisol may be an important predictor of infant outcomes and shed light on the mechanisms through which prenatal maternal stress affects infant psychological health

Toward a Fluid Dance in Seamless Dress: The Field of Pre- and Perinatal Development Challenges Researchers to Integrate Scientific and Spiritual Orientations

The response of humankind to mystery is explored here, relative to the historically sharp distinction between scientific and spiritual ways of knowing. The evolving image of a dancer in a half-male/half-female costume serves as a metaphor for the rapport between these two basic research orientations, and for how they might be reconciled—in the interest of both research and the researcher. Findings from the highly interdisciplinary field of pre- and perinatal development illustrate the need for an integrated approach to understanding \"reality.\

Neural correlates of prenatal stress in young women.

open5noBACKGROUND: Prenatal stress is hypothesized to have a disruptive impact on neurodevelopmental trajectories, but few human studies have been conducted on the long-term neural correlates of prenatal exposure to stress. The aim of this study was to explore the relationship between prenatal stress exposure and gray-matter volume and resting-state functional connectivity in a sample of 35 healthy women aged 14-40 years. METHOD: Voxel-based morphometry and functional connectivity analyses were performed on the whole brain and in specific regions of interest (hippocampus and amygdala). Data about prenatal/postnatal stress and obstetric complications were obtained by interviewing participants and their mothers, and reviewing obstetric records. RESULTS: Higher prenatal stress was associated with decreased gray-matter volume in the left medial temporal lobe (MTL) and both amygdalae, but not the hippocampus. Variance in gray-matter volume of these brain areas significantly correlated with depressive symptoms, after statistically adjusting for the effects of age, postnatal stress and obstetric complications. Prenatal stress showed a positive linear relationship with functional connectivity between the left MTL and the pregenual cortex. Moreover, connectivity between the left MTL and the left medial-orbitofrontal cortex partially explained variance in the depressive symptoms of offspring. CONCLUSIONS: In young women, exposure to prenatal stress showed a relationship with the morphometry and functional connectivity of brain areas involved in the pathophysiology of depressive disorders. These data provide evidence in favor of the hypothesis that early exposure to stress affects brain development and identified the MTL and amygdalae as possible targets of such exposure.openFavaro, Angela; Tenconi, Elena; Degortes, Daniela; Manara, R; Santonastaso, PaoloFavaro, Angela; Tenconi, Elena; Degortes, Daniela; Manara, R; Santonastaso, Paol

Corticotropin-releasing hormone as the homeostatic rheostat of feto-maternal symbiosis and developmental programming In utero and neonatal life

A balanced interaction between the homeostatic mechanisms of mother and the devel- oping organism during pregnancy and in early neonatal life is essential in order to ensure optimal fetal development, ability to respond to various external and internal challenges, protection from adverse programming, and safeguard maternal care availability after parturition. In the majority of pregnancies, this relationship is highly effective resulting in successful outcomes. However, in a number of pathological settings, perturbations of the maternal homeostasis disrupt this symbiosis and initiate adaptive responses with unpre- dictable outcomes for the fetus or even the neonate. This may lead to development of pathological phenotypes arising from developmental reprogramming involving interaction of genetic, epigenetic, and environmental-driven pathways, sometimes with acute conse- quences (e.g., growth impairment) and sometimes delayed (e.g., enhanced susceptibility to disease) that last well into adulthood. Most of these adaptive mechanisms are activated and controlled by hormones of the hypothalamo-pituitary adrenal axis under the influ- ence of placental steroid and peptide hormones. In particular, the hypothalamic peptide corticotropin-releasing hormone (CRH) plays a key role in feto-maternal communication by orchestrating and integrating a series of neuroendocrine, immune, metabolic, and behavioral responses. CRH also regulates neural networks involved in maternal behavior and this determines efficiency of maternal care and neonate interactions. This review will summarize our current understanding of CRH actions during the perinatal period, focusing on the physiological roles for both mother and offspring and also how external challenges can alter CRH actions and potentially impact on fetus/neonate health

Stress and birth outcomes: evidence from terrorist attacks in Colombia

This paper estimates the impact of random terrorist attacks (landmines) in Colombia onthe health of babies born between 1998 and 2003. The results suggest that these types of terrorist activities that occur during a woman´s first trimester of pregnancy have a negative and significant impact on child health outcomes such as birth weight and preterm deliveries, and behaviors such as use of prenatal care. These findings persist when mother fixed effects are included, suggesting that neither observable nor unobservable characteristics of the mothers are driving the results. The paper contributes to the existing literature by identifying yet another important channel through which violence affects economic well being. Given that studies have found a strong link between Low Birth Weight (LBW) and short and long-term socioeconomic outcomes, the negative consequences of violence identified in this paper may have long-term effects on economic activity.birth weight, health, violence, landmine, terrorism

Fantastic alterities and The Sandman

This article explores the ways in which the comics medium enhances our understanding of literary models of the Fantastic. It examines the presence and depiction of multiple worlds in Neil Gaiman’s The Sandman, with specific reference to the role of the comics medium and its denial of mimesis when creating such alterities. It initially uses literature review to establish a contemporary working model of the Fantastic, taking as its basis the framework devised by Tzvetan Todorov, and incorporating the later work of Rosemary Jackson, A B Chanady, and Christine Brooke-Rose. It establishes the position of the Fantastic as a literary mode lying between the marvellous (supernatural accepted) and the uncanny (supernatural explained), and clarifies the distinction between the mode of the Fantastic (which encompasses various genres) and the genre itself. The article then considers the ways in which both the form and content of the comics medium sustain the mode of the fantastic. It broadly discusses the ways in which the following factors contribute to this process: • subject matter: fantastic events, super powers, alternate worlds • non-realistic aesthetic: pop art, stylised visuals, fiction of fonts (invoking the tension between hand-drawn and computerised artwork or lettering) • authorial reticence: the possibilities for surpassing or discarding narrative voice • the role of the reader: as both interpreter and co-creator. It then focuses more closely upon the genre of the Fantastic, establishing the ways in which this genre is opposed to both magical realism (outright fantasy) and realism (where such events are explained). It summarises the role of various qualities of the Fantastic in this regard, which include an antinomy between the natural and supernatural, author reticence, over- or under-determined language, and a defiance of absolute meaning in favour of interpretation or hesitation . The article then proceeds to two case studies, taken from Neil Gaiman’s The Sandman: A Game of You and The Kindly Ones. The first analyses the construction of two contrasting alterities (‘The Land’ and ‘New York’) and examines the ways in which, despite initial appearances, these two worlds are both equally removed from the referent of ‘reality’. It proceeds to discuss the use made of over- and under-determined signifiers, the transformation motif, intertextuality, and the redefinition of static notions (home, gender) as fluid and undefined. It deconstructs The Kindly Ones in similar terms, considering the ways in which its triple alterities are all simultaneously validated by the text and the role of motifs such as multiple names and duplicated characters. It concludes that, like the Fantastic, the comics medium exposes the notion of ‘reality’ as a constructed referent, which the text’s alterities comment on. The nature of the medium allows for the construction and sustenance of multiple worlds without recourse to a stable notion of reality. As the reader’s hesitation destabilises interpretation of reality versus fantasy, absolute meaning is denied. It therefore seems that comics offer what might be best described as a postmodern vision of the Fantastic

Spartan Daily, October 16, 2003

Volume 121, Issue 35https://scholarworks.sjsu.edu/spartandaily/9901/thumbnail.jp

Spartan Daily, October 16, 2003

Volume 121, Issue 35https://scholarworks.sjsu.edu/spartandaily/9901/thumbnail.jp