6,024 research outputs found

    QuASeR -- Quantum Accelerated De Novo DNA Sequence Reconstruction

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    In this article, we present QuASeR, a reference-free DNA sequence reconstruction implementation via de novo assembly on both gate-based and quantum annealing platforms. Each one of the four steps of the implementation (TSP, QUBO, Hamiltonians and QAOA) is explained with simple proof-of-concept examples to target both the genomics research community and quantum application developers in a self-contained manner. The details of the implementation are discussed for the various layers of the quantum full-stack accelerator design. We also highlight the limitations of current classical simulation and available quantum hardware systems. The implementation is open-source and can be found on https://github.com/prince-ph0en1x/QuASeR.Comment: 24 page

    Multistart Methods for Quantum Approximate Optimization

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    Hybrid quantum-classical algorithms such as the quantum approximate optimization algorithm (QAOA) are considered one of the most promising approaches for leveraging near-term quantum computers for practical applications. Such algorithms are often implemented in a variational form, combining classical optimization methods with a quantum machine to find parameters to maximize performance. The quality of the QAOA solution depends heavily on quality of the parameters produced by the classical optimizer. Moreover, the presence of multiple local optima in the space of parameters makes it harder for the classical optimizer. In this paper we study the use of a multistart optimization approach within a QAOA framework to improve the performance of quantum machines on important graph clustering problems. We also demonstrate that reusing the optimal parameters from similar problems can improve the performance of classical optimization methods, expanding on similar results for MAXCUT

    Advantages of Unfair Quantum Ground-State Sampling

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    The debate around the potential superiority of quantum annealers over their classical counterparts has been ongoing since the inception of the field by Kadowaki and Nishimori close to two decades ago. Recent technological breakthroughs in the field, which have led to the manufacture of experimental prototypes of quantum annealing optimizers with sizes approaching the practical regime, have reignited this discussion. However, the demonstration of quantum annealing speedups remains to this day an elusive albeit coveted goal. Here, we examine the power of quantum annealers to provide a different type of quantum enhancement of practical relevance, namely, their ability to serve as useful samplers from the ground-state manifolds of combinatorial optimization problems. We study, both numerically by simulating ideal stoquastic and non-stoquastic quantum annealing processes, and experimentally, using a commercially available quantum annealing processor, the ability of quantum annealers to sample the ground-states of spin glasses differently than classical thermal samplers. We demonstrate that i) quantum annealers in general sample the ground-state manifolds of spin glasses very differently than thermal optimizers, ii) the nature of the quantum fluctuations driving the annealing process has a decisive effect on the final distribution over ground-states, and iii) the experimental quantum annealer samples ground-state manifolds significantly differently than thermal and ideal quantum annealers. We illustrate how quantum annealers may serve as powerful tools when complementing standard sampling algorithms.Comment: 13 pages, 11 figure
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