Volume 6, Number 2, June 1986 OLAC Newsletter

Digitized June 1986 issue of the OLAC Newsletter

Special Libraries, February 1924

Volume 15, Issue 2https://scholarworks.sjsu.edu/sla_sl_1924/1001/thumbnail.jp

Special Libraries, April 1912

Volume 3, Issue 4https://scholarworks.sjsu.edu/sla_sl_1912/1003/thumbnail.jp

Special Libraries, February 1924

Volume 15, Issue 2https://scholarworks.sjsu.edu/sla_sl_1924/1001/thumbnail.jp

Synthesis of Melting Gels Using Mono-Substituted and Di-Substituted Alkoxysiloxanes

Hybrid organic-inorganic sol-gel materials containing silica were first called “ORMOSILs” in 1984.1 Since then, the number of hybrid organicinorganic combinations has increased rapidly.2 Hybrid materials have remarkable features resulting from the synergistic combination of both inorganic and organic components that make them suitable for a wide range of applications such as electrochemical devices, biomedical applications including drug delivery, and electronic and optoelectronic applications including light-emitting diodes, photodiodes, solar cells, gas sensors and field effect transistors. Generally, organic-inorganic materials are classified in two broad categories: Class I materials where the organic and inorganic components are embedded one within the other and display weak bonds, and Class II materials where there are strong covalent bonds between the inorganic and organic components.3 For more than 25 years hybrid gels have been grown by sol-gel process.4 Since sol-gel processing is a low temperature method, it is only natural that sol-gel processing has been extended to hybrid materials with retained organic content. Ordinarily, the outcome of the sol-gel process with the precursor tetraethylorthosilicate (TEOS) (Aldrich Prod. No. 333859) is a 3-dimensional network. TEOS, with 4 identical groups attached to Si, undergoes hydrolysis and polycondensation reactions. The 4 identical groups can be changed to, for example, 3 identical groups and one group with a direct Si-C bond. While the remaining 3 ethoxy groups are reactive to hydrolysis, the substituted group, for example, methyl, is not

Special Libraries, May-June 1927

Volume 18, Issue 5https://scholarworks.sjsu.edu/sla_sl_1927/1004/thumbnail.jp

A Complement Receptor C5a Antagonist Regulates Epithelial to Mesenchymal Transition and Crystallin Expression After Lens Cataract Surgery in Mice

Purpose: To evaluate the effects of complement employing a mouse model for secondary cataract. Methods: The role of complement receptor C5a (CD88) was evaluated after cataract surgery in mice. An antagonist specific to C5a receptor was administered intraperitoneally to mice. Epithelial to mesenchymal transition (EMT) was evaluated by alpha-smooth muscle actin (α-SMA) staining and proliferation by bromodeoxyuridine (5-bromo-2\u27- deoxyuridine, BrdU) incorporation. Gene expression patterns was examined by microarray analysis and quantitative polymerase chain reaction (QPCR). Results: We found that administration of a C5aR antagonist in C57BL/6J mice decreases EMT, as evidenced by α-SMA expression, and cell proliferation. Gene expression by microarray analysis reveals discreet steps of gene regulation in the two major stages that of EMT and lens fiber differentiation in vivo. A hallmark of the microarray analysis is that the antagonist seems to be a novel stage-specific regulator of crystallin genes. At week two, which is marked by lens fiber differentiation genes encoding 12 crystallins and 3 lens-specific structural proteins were severely down-regulated. Conclusions: These results suggest a possible therapeutic role of an antagonist to C5aR in preventing secondary cataracts after surgery. Also these results suggest that crystallin gene expression can be regulated by pro-inflammatory events in the eye

Growth dependant properties of undoped and in-situ doped chemically deposited CdS thin films

This research project examines the growth dependant properties and composition of Cadmium Sulfide thin films produced by the Chemical Bath Deposition Method. The specific areas investigated are the effect of deposition temperature, the effect of an Indium dopant on the films structure and properties, and the effects of post deposition processing such as annealing in air on the film composition. The chemical bath deposition apparatus used has been refined and tested to ensure that the films were grown in a more efficient manner than previously, with more control of the influencing deposition parameters such as temperature. Films grown by the CBD method with this apparatus were durable, yellowish in colour, and adherent to the glass substrates used. The CdS thin films were then subjected to a number of analysis techniques to determine their properties. These techniques include Proton Induced X-ray Emission, Atomic Force Microscopy, Secondary Ion Mass Spectroscopy, Environmental Scanning Electron Microscopy with Charge Contrast Imaging, and Photoconductivity. The results from the analysis of the CdS thin films revealed the presence of nodule structures on the surface of the annealed films. Films produced at lower deposition temperatures seemed to have increased sulfur deficiencies, resulting in an increased Cadmium to sulfur ratio. The Indium doping was found to be inhomogeneous through the depth of the film. The Indium doping concentration in the deposition was also found to be consistent with the concentration found in the films by analysis. Higher deposition temperatures were found to encourage the deposition of colloidal particulates on the surface of the substrates. Annealing of the CdS was found to produce films with surface features that were rougher in appearance

Commercial Availability, Safety, and Hazards

The importance of being able to obtain chemicals commercially, being aware of necessary laboratory precautions, and having access to hazardous-property information is essential for students and researchers. This chapter provides commercial availability links to individual chemical company catalogs and to websites that are linked to multiple commercial sources. It describes laboratory-safety information resources and provides hazardous-property information, for both individual and classes of chemicals, and includes appropriate search techniques. Information on commercial availability, safety, and hazards is interrelated in the sense that commercial chemical companies are responsible for providing Material Safety Data Sheets (MSDSs) for their products. The MSDS for a substance provides basic physical-property information, possible hazardous properties, and instructions for safe use