Penggunaan Metode Bagi Dua Terboboti untuk Mencari Akar-akar suatu Persamaan

Penelitian ini merupakan modifikasi dari Metode Bagi Dua dalam mencari akar persamaan. Dengan Metode Bagi Dua Terboboti dibutuhkan suatu nilai terboboti yang diharapkan meminimumkan banyaknya iterasi sehingga laju kekonvergenan semakin lebih cepat. Hasil penelitian menunjukkan bahwa dengan menggunakan Metode Bagi Dua Terboboti dapat mempercepat laju kekonvergenan yang ditentukan oleh nilai terboboti . Namun, nilai terboboti tidak ditentukan sebelumnya

Exploring the beliefs of young people with cerebral palsy and their families about sport and physical activity in relation to paediatric physiotherapy exercise

Background and Purpose Physiotherapy programmes are an important part of therapeutic input for young people with cerebral palsy (YPwCP), but adherence can be problematic. The involvement of physical activities (PA) could be a possible solution, but YPwCP have lower levels of physical leisure participation than their typically developing peers. Method This qualitative study aimed to explore the beliefs of young people with disabilities and their families about PA in relation to physiotherapy programmes. PA was broadly defined to include not only disability sports, but any aerobic exercise and ‘beliefs’ as perceptions, knowledge and attitudes. A purposive sample of participants from the researcher’s physiotherapy service was invited to undertake semi-structured interviews. Inclusion criteria were 8-19 years of age, having a disability, cognitively able and able to understand and express themselves in English. Parents/care givers were included to capture their discrete perspectives and enable reflective discussion about any synergies or differences between their beliefs and those of their children. Data was analysed using Interpretative Phenomenological Analysis (IPA). Results Two YPwCP and their mothers participated. Three main themes arose: • The feelings evoked by PA, in particular feelings of otherness were underpinned by the desire for ‘normal’ participatory experiences alongside typically developing peers. • External factors and others attitudes affect participation in PA, in particular unfavourable judgements and tokenism within mainstream environments contrasted with a normalising acceptance in disability sports settings. • Physiotherapy and PA are different, participants believed that physiotherapy, physiotherapists and medical venues possessed superior quality, legitimacy and potency. Conclusion The study revealed YPwCP and families’ unique beliefs and preferences concerning PA and the status of physiotherapy and physiotherapists within daily life. Physiotherapists should consider the influence of these beliefs when seeking to signpost to PA or enhance longer-term adherence to programmes within a context of reduced clinical contact

Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model

Alzheimer's disease, progressive supranuclear palsy and frontotemporal dementia are characterized by neuronal expression of aberrant tau protein, tau hyperphosphorylation (pTAU), tau aggregation and neurofibrillary tangle formation sequentially culminating into neuronal cell death, a process termed tauopathy. Our aim was to address at which tauopathy stage neuroinflammation starts and to study the related microglial phenotype. We used Thy1-hTau.P301S (PS) mice expressing human tau with a P301S mutation specifically in neurons. Significant levels of cortical pTAU were present from 2 months onwards. Dystrophic morphological complexity of cortical microglia arose after pTAU accumulation concomitant with increased microglial lysosomal volumes and a significant loss of homeostatic marker Tmem119. Interestingly, we detected increases in neuronal pTAU and postsynaptic structures in the lysosomes of PS microglia. Moreover, the overall cortical postsynaptic density was decreased in 6-month-old PS mice. Together, our results indicate that microglia adopt a pTAU-associated phenotype, and are morphologically and functionally distinct from wild-type microglia after neuronal pTAU accumulation has initiated

Community Economic Development Opportunities in Alberta

The Canadian Community Economic Development Network (CCEDNet) and Momentum, a Calgary, Alberta based community economic development (CED) organization, have issued this brief in Alberta. The brief is directed to the Alberta government. The Government of Alberta is committed to investing in job creation, economic diversification, renewable energy, and being the best place to start and grow a small business. The innovative tools of community economic development (CED) can amplify these economic initiatives by enabling the creation of more social and co-operative enterprises, providing jobs for disadvantaged Albertans, and advancing community-owned renewable energy. The following three strategies can most benefit Albertans given the current economic challenges and opportunities in Alberta: Investing in a Community and Coop Business Secretariat, supported by the Ministry of Economic Development, and hosted at a community based agency. A focus on technical support and connecting businesses to capital and resources. Providing technical, regulatory, and financial support to community-owned start-ups and projects focused on renewable energy development. Creating a market exemption for everyday Albertans (unaccredited investors) to invest in local businesses, social enterprises and co-operatives, and ensuring they benefit from the Alberta Investor Tax Credit.Canadian Community Economic Development Network (CCEDNet); Momentum; Alberta Community and Co-operative Association; Athabasca University; Canadian Worker Co-operative Federation; Edmonton Community Foundation; Edmonton Mennonite Centre for Newcomers; REAP - Respect for the Earth and All People; Social Enterprise Fund (Edmonton); and Thrive - Calgary's Community Economic Development Network

Program: Inauguration Ceremonies Program

Program for the 52nd Presidential inaugural ceremony. Date: January 20, 1993 Box 16 Folder 1

An Ode to Rhode: In Principle and in Practice

This Essay is a tribute to Professor Deborah L. Rhode by Professor Scott L. Cummings and discusses her legacy through the impact of her scholarship and leadership on both legal ethics and the community of legal ethics scholars. It reviews Deborah’s findings on pro bono in principle and in practice, revealing a Janus face—one that is built on altruism but used to benefit individual interests. This Essay shares Professor Cummings’s own experiences with Deborah as an inspirational and courageous individual who spoke truth to power to elevate the interests of those with less power and the ideal of lawyers as a force to make society better

Increasing student performance by changing the assessment practices within an academic writing unit in an enabling program

The production of high quality academic writing often represents a challenge for students in bridging courses. Often, students lack frequently assumed background skills and knowledge, and may have completed secondary school subjects where extended writing tasks were less common. At the University of Notre Dame Australia, Fremantle Campus, staff responded to concerns about student progress with academic writing within the Enabling Program. It was determined that a trial of scaffolded assessment may be of benefit to students in the acquisition of the necessary skills and knowledge. Scaffolded assessment intentionally breaks a single assessment task into sub-components and attempts to teach the students to replicate the same process on future tasks. Data tracking over three Semester 1 entry cohorts demonstrated the approach was of benefit in both the unit and the overall course when scaffolded assessment was utilised. The benefits and reservations regarding the use of scaffolded assessment are outlined

Smoothened (SMO) receptor mutations dictate resistance to\ua0vismodegib in basal cell carcinoma

Basal cell carcinomas (BCCs) and a subset of medulloblastomas are characterized by loss- of-function mutations in the tumor suppressor gene, PTCH1. PTCH1 normally functions by repressing the activity of the Smoothened (SMO) receptor. Inactivating PTCH1 mutations result in constitutive Hedgehog pathway activity through uncontrolled SMO signaling. Tar- geting this pathway with vismodegib, a novel SMO inhibitor, results in impressive tumor regression in patients harboring genetic defects in this pathway. However, a secondary mutation in SMO has been reported in medulloblastoma patients following relapse on vis- modegib to date. This mutation preserves pathway activity, but appears to confer resis- tance by interfering with drug binding. Here we report for the first time on the molecular mechanisms of resistance to vismodegib in two BCC cases. The first case, showing progression after 2 months of continuous vismo- degib (primary resistance), exhibited the new SMO G497W mutation. The second case, showing a complete clinical response after 5 months of treatment and a subsequent pro- gression after 11 months on vismodegib (secondary resistance), exhibited a PTCH1 nonsense mutation in both the pre- and the post-treatment specimens, and the SMO D473Y mutation in the post-treatment specimens only. In silico analysis demonstrated that SMOG497W undergoes a conformational rearrangement resulting in a partial obstruc- tion of the protein drug entry site, whereas the SMO D473Y mutation induces a direct effect on the binding site geometry leading to a total disruption of a stabilizing hydrogen bond network. Thus, the G497W and D473Y SMO mutations may represent two different mech- anisms leading to primary and secondary resistance to vismodegib, respectively