Drug repurposing against COVID-19. focus on anticancer agents

The very limited time allowed to face the COVID-19 pandemic poses a pressing challenge to find proper therapeutic approaches. However, synthesis and full investigation from preclinical studies to phase III trials of new medications is a time-consuming procedure, and not viable in a global emergency, such as the one we are facing

An Open-Publishing Response to the COVID-19 Infodemic

The COVID-19 pandemic catalyzed the rapid dissemination of papers and preprints investigating the disease and its associated virus, SARS-CoV-2. The multifaceted nature of COVID-19 demands a multidisciplinary approach, but the urgency of the crisis combined with the need for social distancing measures present unique challenges to collaborative science. We applied a massive online open publishing approach to this problem using Manubot. Through GitHub, collaborators summarized and critiqued COVID-19 literature, creating a review manuscript. Manubot automatically compiled citation information for referenced preprints, journal publications, websites, and clinical trials. Continuous integration workflows retrieved up-to-date data from online sources nightly, regenerating some of the manuscript\u27s figures and statistics. Manubot rendered the manuscript into PDF, HTML, LaTeX, and DOCX outputs, immediately updating the version available online upon the integration of new content. Through this effort, we organized over 50 scientists from a range of backgrounds who evaluated over 1,500 sources and developed seven literature reviews. While many efforts from the computational community have focused on mining COVID-19 literature, our project illustrates the power of open publishing to organize both technical and non-technical scientists to aggregate and disseminate information in response to an evolving crisis

THE COVID-19 PANDEMIC. SOME ENTREPRENEURIAL ISSUES.

The COVID-19 pandemic changed the rules of our society and led to a rapid shift in the behaviour of individuals. In this context, this paper aims to highlight the consequences of the pandemic on the economic activity, by analysing a number of changes and the corresponding market reactions. To underline how the market is adjusting, we focused on entrepreneurial activity, identifying a number of challenges, limitations, and opportunities. From a methodological point of view, the research approach combines a review of the specialty literature and data analysis. The results show that at a society level, this pandemic filtered entrepreneurs once more according to their skills and knowledge

Impact of COVID-19 on Economic Activities and Poverty Threats in the Asia-Pacific Region

This paper discusses the impact caused by a virus outbreak called coronavirus disease (COVID-19). The virus initially appeared in Wuhan, China, in late 2019, then spread throughout the world, including the Asia-Pacific Region (APR). COVID-19 is believed to have damaged health and the global economy. Unlike the crisis that was caused by many previous disruptions, the impact caused by COVID-19 is wider and bigger. Many economic sectors have been paralyzed and suffered losses, such as production and trade. Export-import cooperation has become a dependency between countries, and this has also been hampered due to the rapid spread of this pandemic. Then, the closure of transportation access and the suggestion to stay at home has made the tourism sector sluggish. Meanwhile, another effect of this pandemic is the emergence of new poor groups due to the rise in layoffs. This study uses qualitative research methods to search for theoretical references relevant to cases or problems found in various works of literature, mainly scientific journals, books, reports, and actual and trusted news on the internet. This study aims to explore the potential of COVID-19 that not only threatens health, but also social, political, and economic spheres. From the analysis, it was concluded that COVID-19 could inhibit all global socio- economic activities that threaten the success of realizing Sustainable Development Goals (SDGs), but on the other hand, this pandemic can also be momentum for a more sustainable life order

Growth Analysis of Global Scientific Research on Covid-19 Pandemic: A Scientometrics Analysis

The purpose of present study is to evaluate the growth of scientific literature pertaining to Coronavirus disease 2019(Covid-19). In sum 1630 document published during 01 January 2020 to 6 April, 2020. Publication data were retrieved from SCOPUS databases using key terms and detailed analysis were made to understand the publication trends, authorship and collaborative pattern, country-wise distribution, core journal and most leading institutes. Study found that 82.88% (1351) of the research documents published on open-access platform which signify the rapid communication of research finding among global scientific communities. ‘BMJ Clinical Research Ed’ found to be most productive journal with 114(6.99%) research articles. China & USA dominates in the publishing research output of 515(31.60%) and 308(18.90%) respectively. There has been an unparalleled growth in the number of publications across the globe on COVID-19 since January 2020

The impact of SARS-CoV-2 in dementia across Latin America : A call for an urgent regional plan and coordinated response

The SARS-CoV-2 global pandemic will disproportionately impact countries with weak economies and vulnerable populations including people with dementia. Latin American and Caribbean countries (LACs) are burdened with unstable economic development, fragile health systems, massive economic disparities, and a high prevalence of dementia. Here, we underscore the selective impact of SARS-CoV-2 on dementia among LACs, the specific strain on health systems devoted to dementia, and the subsequent effect of increasing inequalities among those with dementia in the region. Implementation of best practices for mitigation and containment faces particularly steep challenges in LACs. Based upon our consideration of these issues, we urgently call for a coordinated action plan, including the development of inexpensive mass testing and multilevel regional coordination for dementia care and related actions. Brain health diplomacy should lead to a shared and escalated response across the region, coordinating leadership, and triangulation between governments and international multilateral networks

Bibliometric Landscape of Indian Publications on COVID-19 in 2020

The paper attempts to provide a bibliometric landscape of Indian publications on the topic “COVID-19” in the year 2020. The threat of “COVID-19” pandemic constrained the researchers across the world to foster the research activities to combat the drastic effect of the new emerged infectious disease on human beings turned into pandemic in 2020 resulted influx in publication around the globe and the contribution of India found considerable. As per the data retrieved from Web of Science (WOS) on 29th April, 2021, 62755 documents published at the global level on the topic “COVID-19” in the year 2020 where India occupied 5th position publishing 3104 documents. The study intends to focus on citation, h-index, document type, prolific authors, authorship pattern, degree of collaboration, most preferred journals, publishers, top rated research institutions and research fields under WOS categories

A rapid response to the COVID-19 outbreak: the meta-evidence project

Early in the pandemic, as scientific reports and preliminary research on both clinical and public health aspectsof COVID-19 were rapidly generated, we recognised the need for a dynamic, interactive tool that could captureand collate emerging evidence sources to inform research and decision-making efforts. In particular, we observed that numerous similar research efforts across the globe were happening in parallel - prompting an urgent need to connect research teams with each other and maximize research efficiency. Our colleagues in China provided daily translations of emerging evidence to aid networking between research groups working across the world. Here we describe how the meta-evidence project met daily and ongoing challenges and what was learned as a result. We describe the benefit of finding ways to instead work with better resourced teams and promote collective and open efforts to synthesise the evidence, which in the end, outweighed the considerable costs