Hierarchical classification of liver tumor from CT images based on difference-of-features (DOF)

This manuscript presents an automated classification approach to classifying lesions into four categories of liver diseases, based on Computer Tomography (CT) images. The four diseases types are Cyst, Hemangioma, Hepatocellular carcinoma (HCC), and Metastasis. The novelty of the proposed approach is attributed to utilising the difference of features (DOF) between the lesion area and the surrounding normal liver tissue. The DOF (texture and intensity) is used as the new feature vector that feeds the classifier. The classification system consists of two phases. The first phase differentiates between Benign and Malignant lesions, using a Support Vector Machine (SVM) classifier. The second phase further classifies the Benign into Hemangioma or Cyst and the Malignant into Metastasis or HCC, using a Naïve Bayes (NB) classifier. The experimental results show promising improvements to classify the liver lesion diseases. Furthermore, the proposed approach can overcome the problems of varying intensity ranges, textures between patients, demographics, and imaging devices and settings

A Survey on Deep Learning in Medical Image Analysis

Deep learning algorithms, in particular convolutional networks, have rapidly become a methodology of choice for analyzing medical images. This paper reviews the major deep learning concepts pertinent to medical image analysis and summarizes over 300 contributions to the field, most of which appeared in the last year. We survey the use of deep learning for image classification, object detection, segmentation, registration, and other tasks and provide concise overviews of studies per application area. Open challenges and directions for future research are discussed.Comment: Revised survey includes expanded discussion section and reworked introductory section on common deep architectures. Added missed papers from before Feb 1st 201

Breast-Lesion Characterization using Textural Features of Quantitative Ultrasound Parametric Maps

© 2017 The Author(s). This study evaluated, for the first time, the efficacy of quantitative ultrasound (QUS) spectral parametric maps in conjunction with texture-analysis techniques to differentiate non-invasively benign versus malignant breast lesions. Ultrasound B-mode images and radiofrequency data were acquired from 78 patients with suspicious breast lesions. QUS spectral-analysis techniques were performed on radiofrequency data to generate parametric maps of mid-band fit, spectral slope, spectral intercept, spacing among scatterers, average scatterer diameter, and average acoustic concentration. Texture-analysis techniques were applied to determine imaging biomarkers consisting of mean, contrast, correlation, energy and homogeneity features of parametric maps. These biomarkers were utilized to classify benign versus malignant lesions with leave-one-patient-out cross-validation. Results were compared to histopathology findings from biopsy specimens and radiology reports on MR images to evaluate the accuracy of technique. Among the biomarkers investigated, one mean-value parameter and 14 textural features demonstrated statistically significant differences (p < 0.05) between the two lesion types. A hybrid biomarker developed using a stepwise feature selection method could classify the legions with a sensitivity of 96%, a specificity of 84%, and an AUC of 0.97. Findings from this study pave the way towards adapting novel QUS-based frameworks for breast cancer screening and rapid diagnosis in clinic

Computer-aided classification of liver lesions from CT images based on multiple ROI

This manuscript introduces an automated Computer-Aided Classification (CAD) system to classify liver lesion into Benign or Malignant. The system consists of three stages; firstly, automatic liver segmentation and lesion’s detection. Secondly, extracting features from Multiple ROI, which is the novelty. Finally, classifying liver lesions into benign and malignant. The proposed system divides a segmented lesion into three areas, i.e. inside, outside and border areas. This is because the inside lesion, boundary, and surrounding lesion area contribute different information about the lesion. The features are extracted from the three areas and used to build a new feature vector to feed a classifier. The novelty lies in using the features from the multiple ROIs, and particularly surrounding area (outside), because the Malignant lesion affects the surrounding area differently compared to, the Benign lesion. Utilising the features from inside, border, and outside lesion area supports in better differentiation between benign and malignant lesion. The experimental results showed an enhancement in the classification accuracy (using multiple ROI technique) compared to the accuracy using a single ROI

Recognizing Focal Liver Lesions in Contrast-Enhanced Ultrasound with Discriminatively Trained Spatio-Temporal Model

The aim of this study is to provide an automatic computational framework to assist clinicians in diagnosing Focal Liver Lesions (FLLs) in Contrast-Enhancement Ultrasound (CEUS). We represent FLLs in a CEUS video clip as an ensemble of Region-of-Interests (ROIs), whose locations are modeled as latent variables in a discriminative model. Different types of FLLs are characterized by both spatial and temporal enhancement patterns of the ROIs. The model is learned by iteratively inferring the optimal ROI locations and optimizing the model parameters. To efficiently search the optimal spatial and temporal locations of the ROIs, we propose a data-driven inference algorithm by combining effective spatial and temporal pruning. The experiments show that our method achieves promising results on the largest dataset in the literature (to the best of our knowledge), which we have made publicly available.Comment: 5 pages, 1 figure