2,139 research outputs found

    Working memory revived in older adults by synchronizing rhythmic brain circuits

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    Published in final edited form as: Nat Neurosci. 2019 May ; 22(5): 820–827. doi:10.1038/s41593-019-0371-x.Understanding normal brain aging and developing methods to maintain or improve cognition in older adults are major goals of fundamental and translational neuroscience. Here we show a core feature of cognitive decline—working-memory deficits—emerges from disconnected local and long-range circuits instantiated by theta–gamma phase–amplitude coupling in temporal cortex and theta phase synchronization across frontotemporal cortex. We developed a noninvasive stimulation procedure for modulating long-range theta interactions in adults aged 60–76 years. After 25 min of stimulation, frequency-tuned to individual brain network dynamics, we observed a preferential increase in neural synchronization patterns and the return of sender–receiver relationships of information flow within and between frontotemporal regions. The end result was rapid improvement in working-memory performance that outlasted a 50 min post-stimulation period. The results provide insight into the physiological foundations of age-related cognitive impairment and contribute to groundwork for future non-pharmacological interventions targeting aspects of cognitive decline.Accepted manuscrip

    Mobile Wound Assessment and 3D Modeling from a Single Image

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    The prevalence of camera-enabled mobile phones have made mobile wound assessment a viable treatment option for millions of previously difficult to reach patients. We have designed a complete mobile wound assessment platform to ameliorate the many challenges related to chronic wound care. Chronic wounds and infections are the most severe, costly and fatal types of wounds, placing them at the center of mobile wound assessment. Wound physicians assess thousands of single-view wound images from all over the world, and it may be difficult to determine the location of the wound on the body, for example, if the wound is taken at close range. In our solution, end-users capture an image of the wound by taking a picture with their mobile camera. The wound image is segmented and classified using modern convolution neural networks, and is stored securely in the cloud for remote tracking. We use an interactive semi-automated approach to allow users to specify the location of the wound on the body. To accomplish this we have created, to the best our knowledge, the first 3D human surface anatomy labeling system, based off the current NYU and Anatomy Mapper labeling systems. To interactively view wounds in 3D, we have presented an efficient projective texture mapping algorithm for texturing wounds onto a 3D human anatomy model. In so doing, we have demonstrated an approach to 3D wound reconstruction that works even for a single wound image

    Sparse feature learning for image analysis in segmentation, classification, and disease diagnosis.

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    The success of machine learning algorithms generally depends on intermediate data representation, called features that disentangle the hidden factors of variation in data. Moreover, machine learning models are required to be generalized, in order to reduce the specificity or bias toward the training dataset. Unsupervised feature learning is useful in taking advantage of large amount of unlabeled data, which is available to capture these variations. However, learned features are required to capture variational patterns in data space. In this dissertation, unsupervised feature learning with sparsity is investigated for sparse and local feature extraction with application to lung segmentation, interpretable deep models, and Alzheimer\u27s disease classification. Nonnegative Matrix Factorization, Autoencoder and 3D Convolutional Autoencoder are used as architectures or models for unsupervised feature learning. They are investigated along with nonnegativity, sparsity and part-based representation constraints for generalized and transferable feature extraction

    Automated evaluation of radiodensities in a digitized mammogram database using local contrast estimation

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    Mammographic radiodensity is one of the strongest risk factors for developing breast cancer and there exists an urgent need to develop automated methods for predicting this marker. Previous attempts for automatically identifying and quantifying radiodense tissue in digitized mammograms have fallen short of the ideal. Many algorithms require significant heuristic parameters to be evaluated and set for predicting radiodensity. Many others have not demonstrated the efficacy of their techniques with a sufficient large and diverse patient database. This thesis has attempted to address both of these drawbacks in previous work. Novel automated digital image processing algorithms are proposed that have demonstrated the ability to rapidly sift through digitized mammogram databases for accurately estimating radiodensity. A judicious combination of point-processing, statistical, neural and contrast enhancement techniques have been employed for addressing this formidable problem. The algorithms have been developed and exercised using over 700 mammograms obtained from multiple age and ethnic groups and digitized using more than one type of X-ray digitizer. The automated algorithms developed in this thesis have been validated by comparing the estimation results using 40 of these mammograms with those predicted by a previously established manual segmentation technique. The automated algorithms developed in this thesis show considerable promise to be extremely useful in epidemiological studies when correlating other behavioral and genetic risk factors with mammographic radiodensity

    Texture and Colour in Image Analysis

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    Research in colour and texture has experienced major changes in the last few years. This book presents some recent advances in the field, specifically in the theory and applications of colour texture analysis. This volume also features benchmarks, comparative evaluations and reviews

    Biometrics

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    Biometrics-Unique and Diverse Applications in Nature, Science, and Technology provides a unique sampling of the diverse ways in which biometrics is integrated into our lives and our technology. From time immemorial, we as humans have been intrigued by, perplexed by, and entertained by observing and analyzing ourselves and the natural world around us. Science and technology have evolved to a point where we can empirically record a measure of a biological or behavioral feature and use it for recognizing patterns, trends, and or discrete phenomena, such as individuals' and this is what biometrics is all about. Understanding some of the ways in which we use biometrics and for what specific purposes is what this book is all about
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