22,510 research outputs found

    The Infectious Disease Ontology in the Age of COVID-19

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    The Infectious Disease Ontology (IDO) is a suite of interoperable ontology modules that aims to provide coverage of all aspects of the infectious disease domain, including biomedical research, clinical care, and public health. IDO Core is designed to be a disease and pathogen neutral ontology, covering just those types of entities and relations that are relevant to infectious diseases generally. IDO Core is then extended by a collection of ontology modules focusing on specific diseases and pathogens. In this paper we present applications of IDO Core within various areas of infectious disease research, together with an overview of all IDO extension ontologies and the methodology on the basis of which they are built. We also survey recent developments involving IDO, including the creation of IDO Virus; the Coronaviruses Infectious Disease Ontology (CIDO); and an extension of CIDO focused on COVID-19 (IDO-CovID-19).We also discuss how these ontologies might assist in information-driven efforts to deal with the ongoing COVID-19 pandemic, to accelerate data discovery in the early stages of future pandemics, and to promote reproducibility of infectious disease research

    Ontology of core data mining entities

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    In this article, we present OntoDM-core, an ontology of core data mining entities. OntoDM-core defines themost essential datamining entities in a three-layered ontological structure comprising of a specification, an implementation and an application layer. It provides a representational framework for the description of mining structured data, and in addition provides taxonomies of datasets, data mining tasks, generalizations, data mining algorithms and constraints, based on the type of data. OntoDM-core is designed to support a wide range of applications/use cases, such as semantic annotation of data mining algorithms, datasets and results; annotation of QSAR studies in the context of drug discovery investigations; and disambiguation of terms in text mining. The ontology has been thoroughly assessed following the practices in ontology engineering, is fully interoperable with many domain resources and is easy to extend

    Assessing and refining mappings to RDF to improve dataset quality

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    RDF dataset quality assessment is currently performed primarily after data is published. However, there is neither a systematic way to incorporate its results into the dataset nor the assessment into the publishing workflow. Adjustments are manually -but rarely- applied. Nevertheless, the root of the violations which often derive from the mappings that specify how the RDF dataset will be generated, is not identified. We suggest an incremental, iterative and uniform validation workflow for RDF datasets stemming originally from (semi-) structured data (e.g., CSV, XML, JSON). In this work, we focus on assessing and improving their mappings. We incorporate (i) a test-driven approach for assessing the mappings instead of the RDF dataset itself, as mappings reflect how the dataset will be formed when generated; and (ii) perform semi-automatic mapping refinements based on the results of the quality assessment. The proposed workflow is applied to diverse cases, e.g., large, crowdsourced datasets such as DBpedia, or newly generated, such as iLastic. Our evaluation indicates the efficiency of our workflow, as it significantly improves the overall quality of an RDF dataset in the observed cases

    The Research Object Suite of Ontologies: Sharing and Exchanging Research Data and Methods on the Open Web

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    Research in life sciences is increasingly being conducted in a digital and online environment. In particular, life scientists have been pioneers in embracing new computational tools to conduct their investigations. To support the sharing of digital objects produced during such research investigations, we have witnessed in the last few years the emergence of specialized repositories, e.g., DataVerse and FigShare. Such repositories provide users with the means to share and publish datasets that were used or generated in research investigations. While these repositories have proven their usefulness, interpreting and reusing evidence for most research results is a challenging task. Additional contextual descriptions are needed to understand how those results were generated and/or the circumstances under which they were concluded. Because of this, scientists are calling for models that go beyond the publication of datasets to systematically capture the life cycle of scientific investigations and provide a single entry point to access the information about the hypothesis investigated, the datasets used, the experiments carried out, the results of the experiments, the people involved in the research, etc. In this paper we present the Research Object (RO) suite of ontologies, which provide a structured container to encapsulate research data and methods along with essential metadata descriptions. Research Objects are portable units that enable the sharing, preservation, interpretation and reuse of research investigation results. The ontologies we present have been designed in the light of requirements that we gathered from life scientists. They have been built upon existing popular vocabularies to facilitate interoperability. Furthermore, we have developed tools to support the creation and sharing of Research Objects, thereby promoting and facilitating their adoption.Comment: 20 page
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